| Tag | Content |
|---|---|
| Uniprot ID | E2RSS4 |
| Entrez ID | 491086 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_548206.3 |
| Ensembl protein ID | ENSCAFP00000025369 |
| Ensembl nucleotide ID | ENSCAFG00000017224 |
| Gene name | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 |
| Gene symbol | WFIKKN2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MWAPGCCCRL WSRWAQVAVL LLLLLGVPPR GLTLPPIRYS HAGICPNDMN PNLWVDAQST 60 CKRECETDQE CETYEKCCPN VCGTKSCVAA RYMDVKGKKG PVGMPKEATC DHFMCLQQGS 120 ECDIWDGQPV CKCKDRCEKE PSFTCASDGL TYYNRCYMDA EACSKGITLA VVTCRYHFTW 180 PHTSPPPPET TARPTTASPE TPGMDTVAPA LLNHPVHQSV TVGETVSFLC DVVGRPRPEI 240 TWEKQLEDRE NVVMRPNHVR GNVVVTNIAQ LVIYNAQPQD TGIYTCTARN AGGVLRADFP 300 LSVVRGGQAA TTLESGPNGT AFPAAECLKP PDSEDCGEEQ TRWHFDAQAN NCLTFTFGHC 360 HRNRNHFETY EACMLACMSG PLAVCSLPAL QGPCKAYAPR WAYNSQSGQC QSFVYGGCEG 420 NSNNFESREA CEESCPFPRG NQRCRACKPR QKLVTSFCRS DFVILGRVSE LTEEPDSGRA 480 LVTVDEVLKD EKMGLKFLGQ EPLEVTLLHV DWTCPCPNVT VGETPLIIMG EVDGGMAMLR 540 PDSFVGASSS RRVRKLREVM HKKTCDVLKE FLGLH 575 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN2 | 491086 | E2RSS4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 102178659 | A0A452FFV0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 124857 | Q8TEU8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 278507 | Q7TQN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN2 | 468405 | A0A2I3T853 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | F1RTB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WFIKKN2 | 100345789 | G1SD75 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 287631 | D3Z9K5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0048019 | receptor antagonist activity |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0050431 | transforming growth factor beta binding |
| GO:0048747 | muscle fiber development |
| GO:0043392 | negative regulation of DNA binding |
| GO:0032091 | negative regulation of protein binding |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0001501 | skeletal system development |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR018933 | Netrin_module_non-TIMP |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033639 | WFIKKN2 |