| Tag | Content |
|---|---|
| Uniprot ID | Q7TQN3; Q5SUS5; |
| Entrez ID | 278507 |
| Genbank protein ID | AAP72503.1 |
| Genbank nucleotide ID | XM_006533498.3; XM_006533501.3; XM_006533499.3; XM_006533502.2; NM_181819.2; XM_006533500.3; XM_011249063.2; |
| Ensembl protein ID | ENSMUSP00000053238 |
| Ensembl nucleotide ID | ENSMUSG00000044177 |
| Gene name | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 |
| Gene symbol | Wfikkn2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 24019467 |
| Functional description | Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). Inhibits the biological activity of mature myostatin, but not activin. |
| Sequence | MCAPGYHRFW FHWGLLLLLL LEAPLRGLAL PPIRYSHAGI CPNDMNPNLW VDAQSTCKRE 60 CETDQECETY EKCCPNVCGT KSCVAARYMD VKGKKGPVGM PKEATCDHFM CLQQGSECDI 120 WDGQPVCKCK DRCEKEPSFT CASDGLTYYN RCFMDAEACS KGITLSVVTC RYHFTWPNTS 180 PPPPETTVHP TTASPETLGL DMAAPALLNH PVHQSVTVGE TVSFLCDVVG RPRPELTWEK 240 QLEDRENVVM RPNHVRGNVV VTNIAQLVIY NVQPQDAGIY TCTARNVAGV LRADFPLSVV 300 RGGQARATSE SSLNGTAFPA TECLKPPDSE DCGEEQTRWH FDAQANNCLT FTFGHCHHNL 360 NHFETYEACM LACMSGPLAI CSLPALQGPC KAYVPRWAYN SQTGLCQSFV YGGCEGNGNN 420 FESREACEES CPFPRGNQHC RACKPRQKLV TSFCRSDFVI LGRVSELTEE QDSGRALVTV 480 DEVLKDEKMG LKFLGREPLE VTLLHVDWTC PCPNVTVGET PLIIMGEVDG GMAMLRPDSF 540 VGASSTRRVR KLREVMYKKT CDVLKDFLGL Q 571 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WFIKKN2 | 491086 | E2RSS4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 102178659 | A0A452FFV0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | 124857 | Q8TEU8 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 278507 | Q7TQN3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | WFIKKN2 | 468405 | A0A2I3T853 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WFIKKN2 | F1RTB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WFIKKN2 | 100345789 | G1SD75 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wfikkn2 | 287631 | D3Z9K5 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008191 | metalloendopeptidase inhibitor activity | IEA |
| GO:0048019 | receptor antagonist activity | ISO |
| GO:0048019 | receptor antagonist activity | IBA |
| GO:0050431 | transforming growth factor beta binding | ISO |
| GO:0050431 | transforming growth factor beta binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IGI |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA |
| GO:0010951 | negative regulation of endopeptidase activity | IEA |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | ISO |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | IBA |
| GO:0032091 | negative regulation of protein binding | IDA |
| GO:0043392 | negative regulation of DNA binding | IDA |
| GO:0048747 | muscle fiber development | IMP |
| GO:0060021 | roof of mouth development | IGI |
| GO:2000272 | negative regulation of signaling receptor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IDA |
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0481 | Metalloenzyme inhibitor |
| KW-0483 | Metalloprotease inhibitor |
| KW-0646 | Protease inhibitor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0964 | Secreted |
| KW-0722 | Serine protease inhibitor |
| KW-0732 | Signal |
| InterPro ID | InterPro Term |
|---|---|
| IPR036645 | Elafin-like_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR002350 | Kazal_dom |
| IPR036058 | Kazal_dom_sf |
| IPR002223 | Kunitz_BPTI |
| IPR036880 | Kunitz_BPTI_sf |
| IPR001134 | Netrin_domain |
| IPR018933 | Netrin_module_non-TIMP |
| IPR020901 | Prtase_inh_Kunz-CS |
| IPR008993 | TIMP-like_OB-fold |
| IPR008197 | WAP_dom |
| IPR033639 | WFIKKN2 |