Gene: HKDC1

Basic information

Tag Content
Uniprot ID A0A452E4U0
Entrez ID 102189736
Genbank protein ID
Genbank nucleotide ID XM_018042596.1
Ensembl protein ID ENSCHIP00000007027
Ensembl nucleotide ID ENSCHIG00000010678
Gene name Uncharacterized protein
Gene symbol HKDC1
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MFAVHLLAFY FTKLKEDQIK KVDRFLYHMR LSDETLLDIM ARFQAEMQKG LGKDTNPTAS 60
VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSEE GKRNVQMESQ FYPTPNEIIR 120
GNGTELFEYV ADCLADFMKT KELTQKKLPL GLTFSFPCKQ TKLEEGILLS WTKKFKARGV 180
LGTDVVSSLT NAMKRHQQDL DVDILALVND TVGTMMTCAY DDPYCEVGVI IGTGTNACYM 240
EDMSNIDLVE GDEGRMCINT EWGAFGDDGA LEDIRTEFDR ELDLGSLNPG KQLFEKMISG 300
LYLGELVRLI LLKMAKAGLL FGGEKSSALH IKGKIETRHV AAMERYKEGL ANTREILTDL 360
GLEPSDADCI AVQHVCTIVS FRSANLCAAA LAAILTRLRE NKKLMRLRTT VGMDGTLYKI 420
HPQYPKRLHK VVRKLVPNCD VRFLLSESGS TKGAAMVTAV ASRVQAQRKQ IDKVLALFRL 480
TQEQLVGVRN KMRVEFEYGL KKDTHPLATV KMLPTYVCGM PDGTEKGKFL ALDLGGTNFR 540
VLLVKIRSGR RSVRMYNKIF AIPLEIMQGT GEELFDHIVQ CIADFLDYMG LKGAQLPLGF 600
TFSFPCRQAS IDKGTLIEWT KGFKATDCEG EDVVDMLREA IKRRNEFDLD IVAVVNDTVG 660
TMMTCGYEDS NCEVGLIAGT GSNMCYMEEM RNIELVEGDE GKMCINTEWG GFGDNGCLDD 720
IQTQYDKEVD EGSLNPGKQR YEKMTSGMYL GEIVRQILID LTKQGLLFRG QISERLRTRG 780
IFETKFLSQI ESDRLALLQV RRILQQLGLD STCEDSIVVK EVCGAVSRRA AQLYGAGLAA 840
IVEKRREDQG LEHMRITVGV DGTLYKLHPH FSRILRETVK ELAPQCDVMF MLSEDGSGKG 900
AALITAVAKR LQQAQREH 918

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologHKDC1489019J9JHN0Canis lupus familiarisPredictionMore>>
1:1 orthologHKDC1102189736A0A452E4U0Capra hircusPredictionMore>>
1:1 orthologHKDC1100072686A0A3Q2HML6Equus caballusPredictionMore>>
1:1 orthologHKDC180201Q2TB90Homo sapiensPublicationMore>>
1:1 orthologHkdc1216019Q91W97Mus musculusPredictionMore>>
1:1 orthologHKDC1450504H2Q205Pan troglodytesPredictionMore>>
1:1 orthologHKDC1F1SUF3Sus scrofaPredictionMore>>
1:1 orthologHKDC1100345105G1SMV5Oryctolagus cuniculusPredictionMore>>
1:1 orthologM0R3X7Rattus norvegicusPredictionMore>>
1:1 orthologhkdc1321224B8A5H6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005623 cell
GO:0005739 mitochondrion
GO:0005524 ATP binding
GO:0004340 glucokinase activity
GO:0005536 glucose binding
GO:0001678 cellular glucose homeostasis
GO:0006096 glycolytic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0324 Glycolysis
KW-0418 Kinase
KW-0547 Nucleotide-binding
KW-1185 Reference proteome
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR043129 ATPase_NBD
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N

PROSITE

PROSITE ID PROSITE Term
PS00378 HEXOKINASE_1
PS51748 HEXOKINASE_2

Pfam

Pfam ID Pfam Term
PF00349 Hexokinase_1
PF03727 Hexokinase_2