Gene: hkdc1

Basic information

Tag Content
Uniprot ID B8A5H6
Entrez ID 321224
Genbank protein ID
Genbank nucleotide ID NM_001115125.1
Ensembl protein ID ENSDARP00000056522
Ensembl nucleotide ID ENSDARG00000038703
Gene name Hexokinase
Gene symbol hkdc1
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MFAVHLLSFY FSKLQEDQIK KVDRFLYAMR LSEDQLKDIS ARFRLEMEKG LSSESNAAAA 60
VKMLPTHVYS TPDGSEKGEF LALDLGGSKF KVLQVKVSED GKGKVEMESE TFPIPEEIVN 120
GRGTELFEHV AESLKSFLQK HHINHTRKPL GFTFSFPCAQ SKIDEGVLLS WSKNFKVRGV 180
QGTNVVQSLR KAIRKVGDLD VDVLAMVNDT VGAMMTCGYD DQNCEVGVIV GTGTNACYME 240
EMRHIDLVEG DEGRMCINTE LGAFGDDGVL DDFITSFDRE IDAASINPGK QLFEKMVSGM 300
YMGELVRLIL LRMAKKGLLF RGQISDALRT KGTFHTNHMC LIEQYKSGLE NTKEILEDLG 360
LNPSDDDCIA VQHVCTIVSF RSANLVAAAL AAILTRIREN KKLKTLRTTV GVDGTVYRTH 420
PQYPKRLHKV VRHLVPDCHV RFVLSESGSA KGAAMVTAVA QRLASQRKEI DDTLAAFALT 480
STQLQEVKQK MHVELERGLK KETHPTASVK MLPTYVYRTP DGTERGKYLA LDLGGTNFRV 540
LVVKIRTGMR NSVRMYNKIY AIPLEIMQGT GEELFDHIVQ CISDFLDYMG MKNTRLPLGF 600
TFSFPCNQTG IDKGDLVCWT KGFKATDCEG YDVVDMLREA IKRRNEFDLD IVAIVNDTVG 660
TMMTCAYEDP KCQIGLIAGT GSNVCYMEEM KNIEIVEGDE GQMCVNTEWG GFGENDNIED 720
IRTRYDREVD SGSLNAGKQR FEKMTSGMYL GEIVRQILID LTKRGFLFRG RITERLKTKG 780
IFETKFLSQI ESDRLALLQV RCILQSLGLD STCDDSIIVK EVCGAVSRRA AQLCGAGMAA 840
IVDKIRENRG LDRLDITVGV DGTLYKLHPH FSTILKETVR ELAPNCKVDF ILSEDGSGKG 900
AALITAVARQ HHVQKQEQN 919

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologHKDC1489019J9JHN0Canis lupus familiarisPredictionMore>>
1:1 orthologHKDC1102189736A0A452E4U0Capra hircusPredictionMore>>
1:1 orthologHKDC1100072686A0A3Q2HML6Equus caballusPredictionMore>>
1:1 orthologHKDC180201Q2TB90Homo sapiensPublicationMore>>
1:1 orthologHkdc1216019Q91W97Mus musculusPredictionMore>>
1:1 orthologHKDC1450504H2Q205Pan troglodytesPredictionMore>>
1:1 orthologHKDC1F1SUF3Sus scrofaPredictionMore>>
1:1 orthologHKDC1100345105G1SMV5Oryctolagus cuniculusPredictionMore>>
1:1 orthologM0R3X7Rattus norvegicusPredictionMore>>
1:1 orthologhkdc1321224B8A5H6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005739 mitochondrion
GO:0005524 ATP binding
GO:0008865 fructokinase activity
GO:0004340 glucokinase activity
GO:0005536 glucose binding
GO:0019158 mannokinase activity
GO:0001678 cellular glucose homeostasis
GO:0051156 glucose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0019318 hexose metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0324 Glycolysis
KW-0418 Kinase
KW-0547 Nucleotide-binding
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR043129 ATPase_NBD
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N

PROSITE

PROSITE ID PROSITE Term
PS00378 HEXOKINASE_1
PS51748 HEXOKINASE_2

Pfam

Pfam ID Pfam Term
PF00349 Hexokinase_1
PF03727 Hexokinase_2