Gene: SH3PXD2A

Basic information

Tag Content
Uniprot ID A0A452ED30
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000009768
Ensembl nucleotide ID ENSCHIG00000012501
Gene name Uncharacterized protein
Gene symbol SH3PXD2A
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MLAYCVQDAT VVDVEKRRNP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL QMQLLDKFPI 60
EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY CRALVRLPPH ISQCDEVFRF 120
FEARPEDVNP PKDWAESPKK DVTGADTNAE PMILEQYVVV SNYKKQENSE LSLQAGEVVD 180
VIEKNESGWW FVSTSEEQGW VPATYLEAQN GTRDDSDINT SKTGEVSKRR KAHLRRLDRR 240
WTLGGMVNRQ HSREEKYVTV QPYASQSKDE IGFEKGVTVE VIRKNLEGWW YIRYLGKEGW 300
APASYLKKAK DELPARKKNL AGPVEIIGNI MEISNLLNKK ASGDKETPPA EGEGPEPPIT 360
KKEISLPILC NASNGSALGI PERTVSKLAQ GSPAVARIAP QRSLSDPQVL TAPPPPRRES 420
SLGFQLPKPP EPPSVEVEYY TIAEFQSCIS DGISFRGGQK AEVIDKNSGG WWYVQIGEKE 480
GWAPASYIDK RKKPNLSRRT STLTRPKVPP PAPPSKPKEA DEGPAGPSES QDSPLRLKYE 540
EPEYDIPAFG FDSEPELSEE PTEDSGSGDR RPTQPRRPSP ASSLQRARFK VGGSTEDVAL 600
EEETIYENEG FRPCVEDSLS ARRSSRDSDS PGGSPLSLAR KNSPKSDSPK SSSLLKLKAE 660
KNAQAELGKN HSSASFSSSI TINTTCSSSS SSSSSSLSKN SGDLKPRSAS DAGIRGTPKV 720
GAKKDADPKV GLTSCARAKP SVRPKPFLNR AESQSQERMD ISTLRRQLRP TGQLRGGLKG 780
SKSEDSELPP QTAFEGPSEG SRRGSADLIT LPAASPPCPT KRGREGQATS YTTCSAYQKV 840
QDSEISFPAG VEVQVLEKLE SGWWYVRFGE LEGWAPAHYL VLGGEKEPSD PPVKETDTVA 900
PKSKQNEGKS DSLEKIEKRV QALNTVNQSK RATPPIPSKP PGGFVKTSGA GAVKMRNGVR 960
QVAVRPQSVF VSPPPKDSNL SCALRRNESL TATDSLRGVR RNSSFSAARL AATEAKGRLA 1020
ERAASQGSEP PLLPTQRNGI PVSPVRPKPI EKSQFIHNNL KDVYVSIADY EGDDETAGFQ 1080
EGVSMEVLER NPNGWWYCQI LDGVKPFKGW VPSNYLEKKN

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSH3PXD2A486874F1PLG9Canis lupus familiarisPredictionMore>>
1:1 orthologSH3PXD2AA0A452ED30Capra hircusPredictionMore>>
1:1 orthologSH3PXD2A9644Q5TCZ1Homo sapiensPredictionMore>>
1:1 orthologSh3pxd2a14218O89032CPOMus musculusPublicationMore>>
1:1 orthologSH3PXD2A450714A0A2I3RAY9Pan troglodytesPredictionMore>>
1:1 orthologSH3PXD2A100343675A0A5F9D2I8Oryctolagus cuniculusPredictionMore>>
1:1 orthologSh3pxd2a309460A0A0G2JX92Rattus norvegicusPredictionMore>>
1:1 orthologsh3pxd2aa562018T1ECT1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0002102 podosome
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0002020 protease binding
GO:0001701 in utero embryonic development
GO:0072675 osteoclast fusion
GO:0006801 superoxide metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0728 SH3 domain

Interpro

InterPro ID InterPro Term
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR037961 SH3PXD2_PX
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5

PROSITE

PROSITE ID PROSITE Term
PS50195 PX
PS50002 SH3

Pfam

Pfam ID Pfam Term
PF00787 PX
PF00018 SH3_1