Gene: SH3PXD2A

Basic information

Tag Content
Uniprot ID F1PLG9
Entrez ID 486874
Genbank protein ID
Genbank nucleotide ID XM_014108910.1; XM_014108911.1;
Ensembl protein ID ENSCAFP00000015395
Ensembl nucleotide ID ENSCAFG00000010473
Gene name SH3 and PX domains 2A
Gene symbol SH3PXD2A
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MQLLDKFPIE GGQKDPKQRI IPFLPGKILF RRSHIRDVAV KRLKPIDEYC RALVRLPPHI 60
SQCDEVFRFF EARPEDVNPP KEDYGGSKRK SVWLSSWAES PKKDATGADT NAEPMILEQY 120
VVVSNYKKQE NSELSLQAGE VVDVIEKNES GWWFVSTSEE QGWVPATYLE AQNGTRDDSD 180
INTSKTGEVS KRRKAHLRRL DRRWTLGGMV NRQHSREEKY ITVQPYTSQS KDEIGFEKGV 240
TVEVIRKNLE GWWYIRYLGK EGWAPASYLK KAKDELPARK KNLAGPVEII GNIMEISNLL 300
NKKTSGDKET PPAEGEGPEA PITKKEISLP ILCNASNGSA LGVPERSISK LAQGSPAVAR 360
IAPQRAQISS PNLRTRPPPR RESSLGFQLP KPPEPPSVEV EYYTIAEFQS CISDGISFRG 420
GQKAEVIDKN SGGWWYVQIG EKEGWAPASY IDKRKKPNLS RRTSTLTRPK VPPPAPPSKP 480
KEAEEGPVGS TESQDSPLKL KYEEPEYDIP AFGFDSEPEL SEEPTEDSGS GDRRPAQSHK 540
PSPASSLQRA RFRVGGSSED VALEEETIYE NEGFRPCAED TLSARRSSRD SDSPGGSPLS 600
LARKNSPKSG SPKSSSLLKL KAEKNAQAEL GKNHSSASFS SSITINTTCS SSSSSSSLSK 660
NSGDLKPRSA SDAGIRGTPT VGPKRDADLK AGPTSCARAK PSVRPKPFLS RAESQSQERM 720
DISTLRRQLR PTGQLRGGLK GSKSEDSELP PQTGFEGPGE GSRRGSADLI TPPAATPPCP 780
AKKGREGQAT SYTTCSAYQK VQDSEISFPA GVEVQVLEKL GSGWWYVRFG ELEGWAPSHY 840
LVLGEDEQPD SSGKEPDPGS AKSKQNEGKS DSLEKIEKRV QALNTVNQNK RATPPIPSKP 900
PGGFSKTSAA GAVKMRNGVR QVAVRPQSVF VSPPPKDNNL SCALRRNESL TATDGLRGVR 960
RNSSFSTARS AAAEAKSRLA ERAASQGSDP PLLPAQRNGI PVSPVRPKPI EKSQFIHNNL 1020
KDVYVSIADY EGDEETAGFQ EGVSMEVLER NPNGWWYCQI LDGAKPFKGW VPSNYLEKKN 1080

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSH3PXD2A486874F1PLG9Canis lupus familiarisPredictionMore>>
1:1 orthologSH3PXD2AA0A452ED30Capra hircusPredictionMore>>
1:1 orthologSH3PXD2A9644Q5TCZ1Homo sapiensPredictionMore>>
1:1 orthologSh3pxd2a14218O89032CPOMus musculusPublicationMore>>
1:1 orthologSH3PXD2A450714A0A2I3RAY9Pan troglodytesPredictionMore>>
1:1 orthologSH3PXD2A100343675A0A5F9D2I8Oryctolagus cuniculusPredictionMore>>
1:1 orthologSh3pxd2a309460A0A0G2JX92Rattus norvegicusPredictionMore>>
1:1 orthologsh3pxd2aa562018T1ECT1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0035091 phosphatidylinositol binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0006801 superoxide metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0728 SH3 domain

Interpro

InterPro ID InterPro Term
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR034917 SH3PXD2A
IPR035450 SH3PXD2A_SH3_1
IPR035452 SH3PXD2A_SH3_2
IPR035449 SH3PXD2A_SH3_3
IPR035453 SH3PXD2A_SH3_4
IPR035454 SH3PXD2A_SH3_5

PROSITE

PROSITE ID PROSITE Term
PS50195 PX
PS50002 SH3

Pfam

Pfam ID Pfam Term
PF00787 PX
PF00018 SH3_1