| Tag | Content |
|---|---|
| Uniprot ID | O89032; E9QKJ2; Q148Q8; |
| Entrez ID | 14218 |
| Genbank protein ID | CAA07416.1; AAI18023.1; |
| Genbank nucleotide ID | NM_008018.4; NM_001164717.1; |
| Ensembl protein ID | ENSMUSP00000080325; ENSMUSP00000107430; |
| Ensembl nucleotide ID | ENSMUSG00000053617 |
| Gene name | SH3 and PX domain-containing protein 2A |
| Gene symbol | Sh3pxd2a |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25259869 |
| Functional description | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide (By similarity). |
| Sequence | MLAYCVQDAT VVDVEKRRSP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL QMQLLDKFPI 60 EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY CRALVRLPPH ISQCDEVFRF 120 FEARPEDVNP PKEDYGSSKR KSVWLSSWAE SPKKDVTGAD TNAEPMILEQ YVVVSNYKKQ 180 ENSELSLQAG EVVDVIEKNE SGWWFVSTSE EQGWVPATYL EAQNGTRDDS DINTSKTGEV 240 SKRRKAHLRR LDRRWTLGGM VNRQHSREEK YVTVQPYTSQ SKDEIGFEKG VTVEVIRKNL 300 EGWWYIRYLG KEGWAPASYL KKAKDDLPTR KKNLAGPVEI IGNIMEISNL LNKKASGDKE 360 APAEGEGSEA PITKKEISLP ILCNASNGSA LAIPERTTSK LAQGSPAVAR IAPQRAQISS 420 PNLRTRPPPR RESSLGFQLP KPPEPPSVEV EYYTIAEFQS CISDGISFRG GQKAEVIDKN 480 SGGWWYVQIG EKEGWAPASY IDKRKKPNLS RRTSTLTRPK VPPPAPPSKP KEAEENPVGA 540 CESQGSPLKV KYEEPEYDVP AFGFDSEPEM NEEPSGDRGS GDKHPAQPRR ISPASSLQRA 600 HFKVGESSED VALEEETIYE NEGFRPYTED TLSARGSSGD SDSPGSSSLS LAVKNSPKSD 660 SPKSSSLLKL KAEKNAQAEL GKNQSNISFS SSVTISTTCS SSSSSSSLSK NNGDLKPRSA 720 SDAGIRDTPK VGTKKDPDVK AGLASCARAK PSVRPKPVLN RAESQSQEKM DISSLRRQLR 780 PTGQLRGGLK GSRSEDSELP PQMASEGSRR GSADIIPLTA TTPPCVPKKE WEGQGATYVT 840 CSAYQKVQDS EISFPEGAEV HVLEKAESGW WYVRFGELEG WAPSHYLVAE ENQQPDTASK 900 EGDTGKSSQN EGKSDSLEKI EKRVQALNTV NQSKRATPPI PSKPPGGFGK TSGTVAVKMR 960 NGVRQVAVRP QSVFVSPPPK DNNLSCALRR NESLTATDSL RGVRRNSSFS TARSAAAEAK 1020 GRLAERAASQ GSESPLLPTQ RKGIPVSPVR PKPIEKSQFI HNNLKDVYIS IADYEGDEET 1080 AGFQEGVSME VLEKNPNGWW YCQILDEVKP FKGWVPSNYL EKKN 1124 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SH3PXD2A | 486874 | F1PLG9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SH3PXD2A | A0A452ED30 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SH3PXD2A | 9644 | Q5TCZ1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sh3pxd2a | 14218 | O89032 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SH3PXD2A | 450714 | A0A2I3RAY9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SH3PXD2A | 100343675 | A0A5F9D2I8 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Sh3pxd2a | 309460 | A0A0G2JX92 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sh3pxd2aa | 562018 | T1ECT1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002020 | protease binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IMP |
| GO:0010314 | phosphatidylinositol-5-phosphate binding | IMP |
| GO:0016176 | superoxide-generating NADPH oxidase activator activity | IBA |
| GO:0032266 | phosphatidylinositol-3-phosphate binding | IMP |
| GO:0035091 | phosphatidylinositol binding | IMP |
| GO:0035091 | phosphatidylinositol binding | IBA |
| GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding | IMP |
| GO:0070273 | phosphatidylinositol-4-phosphate binding | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001701 | in utero embryonic development | IMP |
| GO:0006801 | superoxide metabolic process | ISO |
| GO:0006801 | superoxide metabolic process | IBA |
| GO:0043085 | positive regulation of catalytic activity | IEA |
| GO:0072593 | reactive oxygen species metabolic process | IMP |
| GO:0072675 | osteoclast fusion | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002102 | podosome | ISS |
| GO:0002102 | podosome | ISO |
| GO:0002102 | podosome | IDA |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | IDA |
| GO:0030054 | cell junction | IEA |
| GO:0042995 | cell projection | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-8941237 | Invadopodia formation | IEA |