Gene: ITGB6

Basic information

Tag Content
Uniprot ID A0A452EJ04
Entrez ID 102188539
Genbank protein ID
Genbank nucleotide ID XM_005676064.3
Ensembl protein ID ENSCHIP00000012037
Ensembl nucleotide ID ENSCHIG00000013972
Gene name Integrin beta
Gene symbol ITGB6
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MKTFLFTSQV SFQSSRELKR MGIELLCLFF LFLGRNDHVQ GGCAVGGAET CEDCLLIGPQ 60
CAWCSQENFT HLSGVGERCD TPANLLAKGC QLTFIENPVS QVEILTNKPL SIGRQKNSSN 120
IVQISPQSLA LKLRPGLEQT LQVQVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSLLS 180
KEMSKLTSNF RLGFGSFVEK PISPFMKTTP EEIANPCSSI PYFCLPTFGF KHILPLTNDA 240
ERFNEIVKNQ KISANIDTPE GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS 300
RLAGIVIPND GLCHLDSKNE YSMSTILEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN 360
YAKLIPGATV GVLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNSGVPF 420
PHQKKCSHMK VGDTASFNVT VSLPNCERRS RHVILKPVGL GDALEILVSP ECSCDCQKEV 480
EVNSSKCSNG NGSFQCGVCA CNPGHMGHHC ECGEDTLSTE SCKEAPELPS CSGRGDCYCG 540
QCVCHLSPYG NIYGPYCQCD NFSCVRHKGL LCGDNGDCDC GECVCRSGWT GEYCNCTTST 600
DPCVSEDGIL CSGRGDCVCG KCICTNPGAS GPTCERCPTC GDPCNSKRSC IECYLSADGQ 660
AQEECVDKCK LAGATINEEE DFSKDSSVSC SLQGENECLI TFLLTTDNEG KTVIHSINEK 720
DCPKPPNIPM IMLGVSLAIL LIGVVLLCIW KLLVSFHDRK EVAKFEAERS KAKWQTGTNP 780
LYRGSTSTFK NVTYKHKEKP KVDLSMDG 808

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologITGB6282644Q8SQB8Bos taurusPredictionMore>>
1:1 orthologITGB6102188539A0A452EJ04Capra hircusPredictionMore>>
1:1 orthologITGB63694P18564Homo sapiensPredictionMore>>
1:1 orthologItgb616420Q9Z0T9CPOMus musculusPublicationMore>>
1:1 orthologITGB6A0A2I3SC11Pan troglodytesPredictionMore>>
1:1 orthologA0A480ES98Sus scrofaPredictionMore>>
1:1 orthologItgb6311061Q6AYF4Rattus norvegicusPredictionMore>>
1:1 orthologitgb6100499533F1QGX0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0008305 integrin complex
GO:0005178 integrin binding
GO:0038023 signaling receptor activity
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0130 Cell adhesion
KW-1015 Disulfide bond
KW-0401 Integrin
KW-0472 Membrane
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR040622 I-EGF_1
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015436 Integrin_bsu-6
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS00243 INTEGRIN_BETA

Pfam

Pfam ID Pfam Term
PF18372 I-EGF_1
PF08725 Integrin_b_cyt
PF07965 Integrin_B_tail
PF00362 Integrin_beta
PF17205 PSI_integrin