| Tag | Content |
|---|---|
| Uniprot ID | Q8SQB8; Q0PE61; |
| Entrez ID | 282644 |
| Genbank protein ID | ABH04286.1; AAL78039.1; |
| Genbank nucleotide ID | NM_174698.2; XM_005202409.3; |
| Ensembl protein ID | ENSBTAP00000064115 |
| Ensembl nucleotide ID | ENSBTAG00000009080 |
| Gene name | Integrin beta-6 |
| Gene symbol | ITGB6 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). |
| Sequence | MGIELLCLFF LCLGRNDHVQ GGCAVGGAET CEDCLLIGPQ CAWCSQENFT HLSGVGERCD 60 TPANLLAKGC QLTFIENPVS QVEILTNKPL SIGRQKNSSD IVQISPQSLA LKLRPGLEQT 120 LQVQVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSLLS KEMSKLTSNF RLGFGSFVEK 180 PISPFMKTTP EEIANPCSSI PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE 240 GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE 300 YSMSTILEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GVLQKDSGNI 360 LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNTGIPV PHQKKCSHMK VGDTASFNVT 420 VSLPNCERRS RHIILKPVGL GDALEILVSP ECSCDCQKEV EVNSSKCNNG NGSFQCGVCA 480 CHPGHMGHHC ECGEDTLSTE SCKEAPGRPS CSGRGDCYCG QCVCHLSPYG NIYGPYCQCD 540 NFSCVRHKGL LCGDNGDCDC GECVCRSGWT GEYCNCTTST DPCVSEDGIL CSGRGDCVCG 600 KCICTNPGAS GPTCERCPTC GDPCNSKRSC IECYLSADGQ AQEECVDKCK LAGATINEEE 660 DFSKDSFVSC SLQGENECLI TFLLTTDNEG KTVIHSINEK DCPKPPNIPM IMLGVSLAIL 720 LIGVVLLCIW KLLVSFHDRK EVAKFEAERS KAKWQTGTNP LYRGSTSTFK NVTYKHKEKQ 780 KVDLSTDG 788 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB6 | 282644 | Q8SQB8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGB6 | 102188539 | A0A452EJ04 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB6 | 3694 | P18564 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb6 | 16420 | Q9Z0T9 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGB6 | A0A2I3SC11 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480ES98 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Itgb6 | 311061 | Q6AYF4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | itgb6 | 100499533 | F1QGX0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005925 | focal adhesion |
| GO:0034685 | integrin alphav-beta6 complex |
| GO:0005178 | integrin binding |
| GO:0038023 | signaling receptor activity |
| GO:0001618 | virus receptor activity |
| GO:0033627 | cell adhesion mediated by integrin |
| GO:0016477 | cell migration |
| GO:0007160 | cell-matrix adhesion |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:1901388 | regulation of transforming growth factor beta activation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0130 | Cell adhesion |
| KW-0965 | Cell junction |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-1183 | Host cell receptor for virus entry |
| KW-0945 | Host-virus interaction |
| KW-0401 | Integrin |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |