| Tag | Content |
|---|---|
| Uniprot ID | Q6AYF4 |
| Entrez ID | 311061 |
| Genbank protein ID | AAH79069.1 |
| Genbank nucleotide ID | XM_006234232.2; NM_001004263.1; XM_006234233.3; |
| Ensembl protein ID | ENSRNOP00000011030; ENSRNOP00000074271; |
| Ensembl nucleotide ID | ENSRNOG00000008346 |
| Gene name | Integrin beta-6 |
| Gene symbol | Itgb6 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). |
| Sequence | MGIELVCLFL LLLGRNDHVQ GGCAWSGAET CSDCLLTGPH CAWCSQENFT HLSGAGERCD 60 TPENLLAKGC QLPFIENPVS QVEILQNKPL SVGRQKNSSD IVQIAPQSLV LKLRPGGEQT 120 LQVQVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSRLA KEMSKLTSNF RLGFGSFVEK 180 PVSPFMKTTP EEITNPCSSI PYFCLPTFGF KHILPLTDDA ERFNEIVRKQ KISANIDTPE 240 GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDNRNE 300 YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GLLQKDSGNI 360 LQLIISAYEE LRSEVELEVL GDTEGLNLSF TALCSNGILF PHQKKCSHMK VGDTASFNVS 420 VSITNCEKRS RKLIIKPVGL GDTLEILVSA ECDCDCQREV EANSSKCHHG NGSFQCGVCA 480 CNPGHMGPRC ECGEDMVSTD SCKESPGHPS CSGRGDCYCG QCVCHLSPYG SIYGPYCQCD 540 NFSCLRHKGL LCGDNGDCDC GECVCRDGWT GEYCNCTTSR DACASEDGVL CSGRGDCVCG 600 KCVCRNPGAS GPTCERCPTC GDPCNSRRSC IECYLSADGQ AQEECEDKCK ATGATISEEE 660 FSKDTSVPCS LQGENECLIT FLITADNEGK TIIHNISEKD CPKPPNIPMI MLGVSLAILL 720 IGVVLLCIWK LLVSFHDRKE VAKFEAERSK AKWQTGTNPL YRGSTSTFKN VTYKHREKHK 780 VGLSSDG 787 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB6 | 282644 | Q8SQB8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGB6 | 102188539 | A0A452EJ04 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB6 | 3694 | P18564 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb6 | 16420 | Q9Z0T9 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGB6 | A0A2I3SC11 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480ES98 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Itgb6 | 311061 | Q6AYF4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | itgb6 | 100499533 | F1QGX0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005813 | centrosome |
| GO:0009897 | external side of plasma membrane |
| GO:0005925 | focal adhesion |
| GO:0034685 | integrin alphav-beta6 complex |
| GO:0005654 | nucleoplasm |
| GO:0043235 | receptor complex |
| GO:0005178 | integrin binding |
| GO:0038023 | signaling receptor activity |
| GO:0033627 | cell adhesion mediated by integrin |
| GO:0016477 | cell migration |
| GO:0007160 | cell-matrix adhesion |
| GO:0006954 | inflammatory response |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:1901388 | regulation of transforming growth factor beta activation |
| GO:0038044 | transforming growth factor-beta secretion |
| InterPro ID | InterPro Term |
|---|---|
| IPR013111 | EGF_extracell |
| IPR040622 | I-EGF_1 |
| IPR033760 | Integrin_beta_N |
| IPR015812 | Integrin_bsu |
| IPR015436 | Integrin_bsu-6 |
| IPR014836 | Integrin_bsu_cyt_dom |
| IPR012896 | Integrin_bsu_tail |
| IPR036349 | Integrin_bsu_tail_dom_sf |
| IPR002369 | Integrin_bsu_VWA |
| IPR032695 | Integrin_dom_sf |
| IPR016201 | PSI |
| IPR036465 | vWFA_dom_sf |