| Tag | Content |
|---|---|
| Uniprot ID | Q9Z0T9; Q544J9; |
| Entrez ID | 16420 |
| Genbank protein ID | BAC29430.1; AAD17212.1; AAH49185.1; |
| Genbank nucleotide ID | XM_006498810.3; XM_006498811.2; XM_006498808.3; NM_001159564.1; NM_021359.3; XM_006498809.1; |
| Ensembl protein ID | ENSMUSP00000028348; ENSMUSP00000054944; |
| Ensembl nucleotide ID | ENSMUSG00000026971 |
| Gene name | Integrin beta-6 |
| Gene symbol | Itgb6 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19118215 |
| Functional description | Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398). |
| Sequence | MGIELVCLFL LLLGRNDHVQ GGCAWGGAES CSDCLLTGPH CAWCSQENFT HLSGAGERCD 60 TPANLLAKGC QLPFIENPVS RIEVLQNKPL SVGRQKNSSD IVQIAPQSLV LKLRPGREQT 120 LQVQVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSRLA KEMSKLTSNF RLGFGSFVEK 180 PVSPFMKTTP EEITNPCSSI PYFCLPTFGF KHILPLTDDA ERFNEIVRKQ KISANIDTPE 240 GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDHRNE 300 YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GLLQKDSGNI 360 LQLIISAYEE LRSEVELEVL GDTEGLNLSF TALCNNGVLF PHQKKCSHMK VGDTASFNVT 420 VSVSNCEKRS RNLIIKPVGL GDTLEILVSA ECDCDCQREI ETNSSKCHNG NGSFQCGVCT 480 CNPGHMGPHC ECGEDMVSTD SCKESPGHPS CSGRGDCYCG QCICHLSPYG SIYGPYCQCD 540 NFSCLRHKGL LCGDNGDCDC GECVCRDGWT GEYCNCTTNR DSCTSEDGVL CSGRGDCVCG 600 KCVCRNPGAS GPTCERCPTC GDPCNSKRSC IECYLSADGQ AQEECADKCK AIGATISEED 660 FSKDTSVSCS LQGENECLIT FLITTDNEGK TIIHNINEKD CPKPPNIPMI MLGVSLAILL 720 IGVVLLCIWK LLVSFHDRKE VAKFEAERSK AKWQTGTNPL YRGSTSTFKN VTYKHREKHK 780 AGLSSDG 787 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB6 | 282644 | Q8SQB8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGB6 | 102188539 | A0A452EJ04 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB6 | 3694 | P18564 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb6 | 16420 | Q9Z0T9 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGB6 | A0A2I3SC11 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480ES98 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Itgb6 | 311061 | Q6AYF4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | itgb6 | 100499533 | F1QGX0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005178 | integrin binding | IBA |
| GO:0005178 | integrin binding | IPI |
| GO:0038023 | signaling receptor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006954 | inflammatory response | IMP |
| GO:0007160 | cell-matrix adhesion | IBA |
| GO:0007229 | integrin-mediated signaling pathway | IBA |
| GO:0016477 | cell migration | IBA |
| GO:0033627 | cell adhesion mediated by integrin | ISS |
| GO:0033627 | cell adhesion mediated by integrin | ISO |
| GO:0033627 | cell adhesion mediated by integrin | IBA |
| GO:0033627 | cell adhesion mediated by integrin | IDA |
| GO:0038044 | transforming growth factor-beta secretion | IDA |
| GO:1901388 | regulation of transforming growth factor beta activation | ISS |
| GO:1901388 | regulation of transforming growth factor beta activation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005654 | nucleoplasm | ISO |
| GO:0005813 | centrosome | ISO |
| GO:0005925 | focal adhesion | ISS |
| GO:0005925 | focal adhesion | ISO |
| GO:0005925 | focal adhesion | IBA |
| GO:0009897 | external side of plasma membrane | IDA |
| GO:0030054 | cell junction | ISO |
| GO:0034685 | integrin alphav-beta6 complex | ISO |
| GO:0034685 | integrin alphav-beta6 complex | IBA |
| GO:0034685 | integrin alphav-beta6 complex | IDA |
| GO:0043235 | receptor complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1566948 | Elastic fibre formation | IEA |
| R-MMU-2129379 | Molecules associated with elastic fibres | IEA |
| R-MMU-216083 | Integrin cell surface interactions | IEA |
| R-MMU-3000178 | ECM proteoglycans | IEA |