| Tag | Content |
|---|---|
| Uniprot ID | A0A452F1Z6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000018188 |
| Ensembl nucleotide ID | ENSCHIG00000017724 |
| Gene name | CP2 domain-containing protein |
| Gene symbol | GRHL2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | HSHHNKRLVA LVPMPSEPPF NTRRAYTSED EAWKSYLENP LTAATKAMMS INGDEDSAAA 60 LGLLYDYYKV PRDKRLLSVS KASDSQEDQD KRNCLGTSEA QSNLSGGENR VQVLKTVPVN 120 LCLNQDHLEN SKREQYSTNV PESPAIIPVS GITVVKAEDF TPVFMTPPVH YPRGEGEEQR 180 VVIFEQTQYG VPSMAGHSTY LKDDQRSTPD STYSESFKDG NAEKFRSASV GAEEYMYDQT 240 SSGTFQYTLE ATKSLRQKQG EGPMTYLNKG QFYAITLSET GDNKCFRHPI SKVRSVVMVV 300 FSEDKNRDEQ LKYWKYWHSR QHTAKQRVLD IADYKESFNT IGNIEEIAYN AVSFTWDVNE 360 EAKIFITVNC LSTDFSSQKG VKGLPLMIQI DTYSYNNRSN KPIHRAYCQI KVFCDKGAER 420 KIRDEERKQN RKKGKGQASQ TQCNNSSDGK LAAIPLQKKS DITYFKTMPD LHSQPVLFIP 480 DVHFANLQRT GQVYYNTDDE REGSSVLVKR MFRPMEEEFG PAPSKQMKEE GMKRVLLYVR 540 KETDDVFDAL MLKSPTVKGL MEAISEKYGL PVEKIAKLYK KSKKGILVNM DDNIIEHYSN 600 EDTFILNMES MVEGFKITLM EI 622 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GRHL2 | A0A452F1Z6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | GRHL2 | 100056140 | F7BG04 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | 79977 | Q6ISB3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Grhl2 | 252973 | Q8K5C0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GRHL2 | 464320 | H2QWI7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | F1S0Q6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Grhl2 | 299979 | B5DEI9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | grhl2b | 100034503 | F7VJQ5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005911 | cell-cell junction |
| GO:0005654 | nucleoplasm |
| GO:0031490 | chromatin DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0061713 | anterior neural tube closure |
| GO:0070830 | bicellular tight junction assembly |
| GO:0007420 | brain development |
| GO:0043010 | camera-type eye development |
| GO:0003208 | cardiac ventricle morphogenesis |
| GO:0007155 | cell adhesion |
| GO:0008283 | cell population proliferation |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0008544 | epidermis development |
| GO:0060672 | epithelial cell morphogenesis involved in placental branching |
| GO:0090132 | epithelium migration |
| GO:0060324 | face development |
| GO:0060487 | lung epithelial cell differentiation |
| GO:0060463 | lung lobe morphogenesis |
| GO:0035264 | multicellular organism growth |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:0051973 | positive regulation of telomerase activity |
| GO:0044030 | regulation of DNA methylation |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF04516 | CP2 |