| Tag | Content |
|---|---|
| Uniprot ID | H2QWI7; A0A2J8PML2; |
| Entrez ID | 464320 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_519890.6 |
| Ensembl protein ID | ENSPTRP00000035022 |
| Ensembl nucleotide ID | ENSPTRG00000020479 |
| Gene name | Grainyhead like transcription factor 2 |
| Gene symbol | GRHL2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSQESDNNKR LVALVPMPSD PPFNTRRAYT SEDEAWKSYL ENPLTAATKA MMSINGDEDS 60 AAALGLLYDY YKVPRDKRLL SVSKASDSQE DQEKRNCLGT SEAQSNLSGG ENRVQVLKTV 120 PVNLSLNQDH LENSKREQYS ISFPESSAII PVSGITVVKA EDFTPVFMAP PVHYPRGDGE 180 EQRVVIFEQT QYDVPSLATH SAYLKDDQRS TPDSTYSESF KDAATEKFRS ASVGAEEYMY 240 DQTSSGTFQY TLEATKSLRQ KQGEGPMTYL NKGQFYAITL SETGDNKCFR HPISKVRSVV 300 MVVFSEDKNR DEQLKYWKYW HSRQHTAKQR VLDIADYKES FNTIGNIEEI AYNAVSFTWD 360 VNEEAKIFIT VNCLSTDFSS QKGVKGLPLM IQIDTYSYNN RSNKPIHRAY CQIKVFCDKG 420 AERKIRDEER KQNRKKGKGQ ASQTQCNSSS DGKLAAIPLQ KKSDITYFKT MPDLHSQPVL 480 FIPDVHFANL QRTGQVYYNT DDEREGGSVL VKRMFRPMEE EFGPVPSKQM KEEGTKRVLL 540 YVRKETDDVF DALMLKSPTV KGLMEAISEK YGLPVEKIAK LYKKSKKGIL VNMDDNIIEH 600 YSNEDTFILN MESMVEGFKV TLMEI 625 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GRHL2 | A0A452F1Z6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | GRHL2 | 100056140 | F7BG04 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | 79977 | Q6ISB3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Grhl2 | 252973 | Q8K5C0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GRHL2 | 464320 | H2QWI7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | F1S0Q6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Grhl2 | 299979 | B5DEI9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | grhl2b | 100034503 | F7VJQ5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005911 | cell-cell junction |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0031490 | chromatin DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0061713 | anterior neural tube closure |
| GO:0070830 | bicellular tight junction assembly |
| GO:0007420 | brain development |
| GO:0043010 | camera-type eye development |
| GO:0003208 | cardiac ventricle morphogenesis |
| GO:0007155 | cell adhesion |
| GO:0008283 | cell population proliferation |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0008544 | epidermis development |
| GO:0060672 | epithelial cell morphogenesis involved in placental branching |
| GO:0090132 | epithelium migration |
| GO:0060324 | face development |
| GO:0060487 | lung epithelial cell differentiation |
| GO:0060463 | lung lobe morphogenesis |
| GO:0035264 | multicellular organism growth |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:0021915 | neural tube development |
| GO:0051973 | positive regulation of telomerase activity |
| GO:0044030 | regulation of DNA methylation |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF04516 | CP2 |