| Tag | Content |
|---|---|
| Uniprot ID | F7BG04 |
| Entrez ID | 100056140 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005613235.2 |
| Ensembl protein ID | ENSECAP00000011766 |
| Ensembl nucleotide ID | ENSECAG00000013681 |
| Gene name | Grainyhead like transcription factor 2 |
| Gene symbol | GRHL2 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSQESDNNKR LVALVPMPSD PPFNTRRAYT SEDEAWKSYL ENPLTAATKA MMSINGDEDS 60 AAALGLLYDY YKVPRDKRLL SVSKASDSQE DQDKRNCLGT SEAQSNLSGG ENRVQVLKTV 120 PVNLSLNQDH LENSKREQYS TNVPESPAVV PVSGITVVKA EDFTPVFMAP PVHYPRGDGE 180 EQRVVIFEQT QYGVPSMVGH STYLKDDQRS TPDSTYSESF KDGTTEKFRS ASVGAEEYMY 240 DQTASGTFQY TLEATKSLRQ KQGEGPMTYL NKGQFYAITL SETGDNKCFR HPISKVRSVV 300 MVVFSEDKNR DEQLKYWKYW HSRQHTAKQR VLDIADYKES FNTIGNIEEI AYNAVSFTWD 360 VNEEAKIFIT VNCLSTDFSS QKGVKGLPLM IQIDTYSYNN RSNKPIHRAY CQIKVFCDKG 420 AERKIRDEER KQNRKKGKGQ ASQTQCNNSS DGKLAAIPLQ KKSDITYFKT MPDLHSQPVL 480 FIPDVHFANL QRTGQVYYNT DDEREGSSVL VKRMFRPMEE EFGPAPSKQM KEEGMKRVLL 540 YVRKETDDVF DALMLKSPTV KGLMEAISEK YGLPVEKIAK LYKKSKKGIL VNMDDNIIEH 600 YSNEDTFILN MESMVEGFKI TLMEI 625 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GRHL2 | A0A452F1Z6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | GRHL2 | 100056140 | F7BG04 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | 79977 | Q6ISB3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Grhl2 | 252973 | Q8K5C0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GRHL2 | 464320 | H2QWI7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | F1S0Q6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Grhl2 | 299979 | B5DEI9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | grhl2b | 100034503 | F7VJQ5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005911 | cell-cell junction |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0031490 | chromatin DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0061713 | anterior neural tube closure |
| GO:0070830 | bicellular tight junction assembly |
| GO:0007420 | brain development |
| GO:0043010 | camera-type eye development |
| GO:0003208 | cardiac ventricle morphogenesis |
| GO:0007155 | cell adhesion |
| GO:0008283 | cell population proliferation |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0008544 | epidermis development |
| GO:0060672 | epithelial cell morphogenesis involved in placental branching |
| GO:0090132 | epithelium migration |
| GO:0060324 | face development |
| GO:0060487 | lung epithelial cell differentiation |
| GO:0060463 | lung lobe morphogenesis |
| GO:0035264 | multicellular organism growth |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:0021915 | neural tube development |
| GO:0051973 | positive regulation of telomerase activity |
| GO:0044030 | regulation of DNA methylation |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF04516 | CP2 |