| Tag | Content |
|---|---|
| Uniprot ID | B5DEI9 |
| Entrez ID | 299979 |
| Genbank protein ID | AAI68688.1 |
| Genbank nucleotide ID | NM_001134527.1 |
| Ensembl protein ID | ENSRNOP00000009337 |
| Ensembl nucleotide ID | ENSRNOG00000007000 |
| Gene name | Grainyhead-like transcription factor 2 |
| Gene symbol | Grhl2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSQESDNNKR LVALVPMPSD PPFNTRRAYT SEDEAWKSYL ENPLTAATKA MMSINGDEDS 60 AAALGLLYDY YKVPRDKRLL SVSKASDSQE DEEKRNCLGT SEAQINLSGG ENRVQVLKTV 120 PVNLCLSQDH MENSKREQYS VSITESPAVI PVSGITVVKA EDFTPVFMAP PVHYPRADGG 180 EEQRVVIFEQ TQYDLPSIAS HSSYLKDDQR STPDSTYSES FKDGAPEKFR STSVGADEYT 240 YDQTGSGTFQ YTLEATKSLR QKQGEGPMTY LNKGQFYAIT LSETGDNKCF RHPISKVRSV 300 VMVVFSEDKN RDEQLKYWKY WHSRQHTAKQ RVLDIADYKE SFNTIGNIEE IAYNAVSFTW 360 DVNEEAKIFI TVNCLSTDFS SQKGVKGLPL MIQIDTYSYN NRSNKPIHRA YCQIKVFCDK 420 GAERKIRDEE RKQNRKKGKG QASQTQCSNS SDGKMAAIPL QKKSDITYFK TMPDLHSQPV 480 LFIPDVHFAN LQRTGQVYYN TDDEREGSSV LVKRMFRPME EEFGPTPSKQ IKEENVKRVL 540 LYVRKENDDV FDALMLKSPT VKGLMEALSE KYGLPVEKIT KLYKKSKKGI LVNMDDNIIE 600 HYSNEDTFIL NMESMVEGFK ITLMEI 626 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GRHL2 | A0A452F1Z6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | GRHL2 | 100056140 | F7BG04 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | 79977 | Q6ISB3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Grhl2 | 252973 | Q8K5C0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GRHL2 | 464320 | H2QWI7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GRHL2 | F1S0Q6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Grhl2 | 299979 | B5DEI9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | grhl2b | 100034503 | F7VJQ5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005911 | cell-cell junction |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0031490 | chromatin DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0061713 | anterior neural tube closure |
| GO:0070830 | bicellular tight junction assembly |
| GO:0007420 | brain development |
| GO:0043010 | camera-type eye development |
| GO:0003208 | cardiac ventricle morphogenesis |
| GO:0007155 | cell adhesion |
| GO:0034329 | cell junction assembly |
| GO:0008283 | cell population proliferation |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0048568 | embryonic organ development |
| GO:0008544 | epidermis development |
| GO:0003382 | epithelial cell morphogenesis |
| GO:0060672 | epithelial cell morphogenesis involved in placental branching |
| GO:0090132 | epithelium migration |
| GO:0060324 | face development |
| GO:0001701 | in utero embryonic development |
| GO:0060487 | lung epithelial cell differentiation |
| GO:0060463 | lung lobe morphogenesis |
| GO:0035264 | multicellular organism growth |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:0001843 | neural tube closure |
| GO:0021915 | neural tube development |
| GO:0051973 | positive regulation of telomerase activity |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0044030 | regulation of DNA methylation |
| GO:0010468 | regulation of gene expression |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0030323 | respiratory tube development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF04516 | CP2 |