Gene: INSIG1

Basic information

Tag Content
Uniprot ID A0A452FSS4
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000027394
Ensembl nucleotide ID ENSCHIG00000023323
Gene name Insulin-induced gene protein
Gene symbol INSIG1
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Mediates feedback control of cholesterol synthesis.
Sequence
ACRTRPRDPG PRRPPYNSGH VNSWHHHLVQ RSLVLFSVGV VLALVLNLLQ VQRNVTLFPD 60
EVIATIFSSA WWVPPCCGTA AAVVGLLYPC IDSHLGEPHK FKREWASVMR CVAVFVGINH 120
ASAKLDFANN VQLSLTLAAL SLGLWWTFDR SRSGLGLGIT IAFLATLITQ LLVYNGVYQY 180
TSPDFLYIRS WLPCIFFSGG VTVGNIGRQL AMVRKVVTLA SRES 224

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologINSIG1511899A0JNC3Bos taurusPredictionMore>>
1:1 orthologINSIG1475554A0A5F4D7Y9Canis lupus familiarisPredictionMore>>
1:1 orthologINSIG1A0A452FSS4Capra hircusPredictionMore>>
1:1 orthologINSIG1100065774A0A3Q2HPQ1Equus caballusPredictionMore>>
1:1 orthologINSIG13638O15503Homo sapiensPredictionMore>>
1:1 orthologInsig1231070Q8BGI3CPOMus musculusPublicationMore>>
1:1 orthologINSIG1463839H2QVN6Pan troglodytesPredictionMore>>
1:1 orthologinsig1334189Q8AV61Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0008203 cholesterol metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0153 Cholesterol metabolism
KW-0256 Endoplasmic reticulum
KW-0443 Lipid metabolism
KW-0472 Membrane
KW-1185 Reference proteome
KW-0753 Steroid metabolism
KW-1207 Sterol metabolism
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR009904 INSIG-1
IPR025929 INSIG_fam

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07281 INSIG