CleftGeneDB-Search

Gene: INSIG1

Basic information

Tag	Content
Uniprot ID	O15503; A4D2N1; A8K6L0; Q53XW8; Q9BUV5;
Entrez ID	3638
Genbank protein ID	AAB69121.1; AAM44086.1; AAP35891.1; BAF84364.1; EAX04529.1; EAL23729.1; EAX04530.1; AAH01880.1; EAL23730.1;
Genbank nucleotide ID	NM_001346594.1; NM_005542.5; XM_017012177.1; NM_198337.3; NM_198336.3; NM_001346590.1; NM_001346591.1; NM_001346593.1; NM_001346592.1;
Ensembl protein ID	ENSP00000344035; ENSP00000344741;
Ensembl nucleotide ID	ENSG00000186480
Gene name	Insulin-induced gene 1 protein
Gene symbol	INSIG1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
Sequence	MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP 60 RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA 120 TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK 180 LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD 240 FLYIRSWLPC IFFSGGVTVG NIGRQLAMGV PEKPHSD 277

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	INSIG1	511899	A0JNC3		Bos taurus	Prediction	More>>
1:1 ortholog	INSIG1	475554	A0A5F4D7Y9		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	INSIG1		A0A452FSS4		Capra hircus	Prediction	More>>
1:1 ortholog	INSIG1	100065774	A0A3Q2HPQ1		Equus caballus	Prediction	More>>
1:1 ortholog	INSIG1	3638	O15503		Homo sapiens	Prediction	More>>
1:1 ortholog	Insig1	231070	Q8BGI3	CPO	Mus musculus	Publication	More>>
1:1 ortholog	INSIG1	463839	H2QVN6		Pan troglodytes	Prediction	More>>
1:1 ortholog	insig1	334189	Q8AV61		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1418116245	p.Arg3Ile	missense variant	-	NC_000007.14:g.155298293G>T	gnomAD
rs1161259141	p.Leu4Ter	stop gained	-	NC_000007.14:g.155298296T>A	gnomAD
rs1161259141	p.Leu4Trp	missense variant	-	NC_000007.14:g.155298296T>G	gnomAD
rs963954503	p.His5Arg	missense variant	-	NC_000007.14:g.155298299A>G	TOPMed
rs746752379	p.Asp6Glu	missense variant	-	NC_000007.14:g.155298303C>A	ExAC,gnomAD
rs777657402	p.Asp6Tyr	missense variant	-	NC_000007.14:g.155298301G>T	ExAC,gnomAD
rs1161652282	p.Asp6Ala	missense variant	-	NC_000007.14:g.155298302A>C	TOPMed,gnomAD
rs746752379	p.Asp6Glu	missense variant	-	NC_000007.14:g.155298303C>G	ExAC,gnomAD
rs1342614207	p.His7Arg	missense variant	-	NC_000007.14:g.155298305A>G	TOPMed
rs11544449	p.Trp9Ter	stop gained	-	NC_000007.14:g.155298311G>A	gnomAD
rs1395941774	p.Trp9Cys	missense variant	-	NC_000007.14:g.155298312G>C	TOPMed
rs11544449	p.Trp9Leu	missense variant	-	NC_000007.14:g.155298311G>T	gnomAD
rs752068072	p.Ser12Cys	missense variant	-	NC_000007.14:g.155298320C>G	ExAC,TOPMed,gnomAD
rs768727914	p.Cys13Ter	stop gained	-	NC_000007.14:g.155298324T>A	ExAC,gnomAD
rs373395354	p.Cys13Ser	missense variant	-	NC_000007.14:g.155298322T>A	ESP,ExAC,TOPMed,gnomAD
rs1466887645	p.Ala14Ser	missense variant	-	NC_000007.14:g.155298325G>T	TOPMed
rs1166933943	p.His15Arg	missense variant	-	NC_000007.14:g.155298329A>G	TOPMed
rs748711429	p.His15Tyr	missense variant	-	NC_000007.14:g.155298328C>T	ExAC,TOPMed,gnomAD
rs1356048453	p.Arg19Pro	missense variant	-	NC_000007.14:g.155298341G>C	gnomAD
rs896185421	p.Arg20Gln	missense variant	-	NC_000007.14:g.155298344G>A	TOPMed,gnomAD
rs951081544	p.Gly21Val	missense variant	-	NC_000007.14:g.155298347G>T	gnomAD
rs773664641	p.Pro22Arg	missense variant	-	NC_000007.14:g.155298350C>G	ExAC,gnomAD
rs772417804	p.Pro22Ala	missense variant	-	NC_000007.14:g.155298349C>G	ExAC,TOPMed,gnomAD
rs1257535476	p.Pro23Ser	missense variant	-	NC_000007.14:g.155298352C>T	gnomAD
rs760923827	p.Pro23Leu	missense variant	-	NC_000007.14:g.155298353C>T	ExAC
rs766189055	p.Arg24Gly	missense variant	-	NC_000007.14:g.155298355C>G	ExAC,gnomAD
rs1184909326	p.Arg24Gln	missense variant	-	NC_000007.14:g.155298356G>A	gnomAD
rs1377830446	p.Ser26Arg	missense variant	-	NC_000007.14:g.155298363C>G	gnomAD
rs1129825	p.Ala27Thr	missense variant	-	NC_000007.14:g.155298364G>A	-
rs1129825	p.Ala27Thr	missense variant	-	NC_000007.14:g.155298364G>A	UniProt,dbSNP
VAR_027683	p.Ala27Thr	missense variant	-	NC_000007.14:g.155298364G>A	UniProt
rs1434744508	p.Ala27Val	missense variant	-	NC_000007.14:g.155298365C>T	TOPMed,gnomAD
rs1367722240	p.Ala28Val	missense variant	-	NC_000007.14:g.155298368C>T	TOPMed,gnomAD
rs1388248807	p.Ala31Val	missense variant	-	NC_000007.14:g.155298377C>T	gnomAD
rs762445916	p.Ala31Thr	missense variant	-	NC_000007.14:g.155298376G>A	ExAC,TOPMed,gnomAD
rs764867200	p.Ala32Gly	missense variant	-	NC_000007.14:g.155298380C>G	ExAC,TOPMed,gnomAD
rs752113166	p.Lys33Arg	missense variant	-	NC_000007.14:g.155298383A>G	ExAC,TOPMed,gnomAD
rs758403899	p.Val34Ile	missense variant	-	NC_000007.14:g.155298385G>A	ExAC,gnomAD
rs1358973756	p.Val34Ala	missense variant	-	NC_000007.14:g.155298386T>C	TOPMed
rs199524513	p.Gly35Trp	missense variant	-	NC_000007.14:g.155298388G>T	ExAC,TOPMed,gnomAD
COSM4834219	p.Glu36Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155298393G>C	NCI-TCGA Cosmic
rs1340304058	p.Glu36Lys	missense variant	-	NC_000007.14:g.155298391G>A	TOPMed,gnomAD
rs1229591246	p.Met37Ile	missense variant	-	NC_000007.14:g.155298396G>A	gnomAD
rs1300189272	p.Asn39Lys	missense variant	-	NC_000007.14:g.155298402C>A	gnomAD
rs1340677254	p.Val40Ile	missense variant	-	NC_000007.14:g.155298403G>A	gnomAD
rs1228250112	p.Ser43Phe	missense variant	-	NC_000007.14:g.155298413C>T	gnomAD
rs376046556	p.Pro45Ser	missense variant	-	NC_000007.14:g.155298418C>T	gnomAD
rs369178429	p.Ala49Val	missense variant	-	NC_000007.14:g.155298431C>T	ExAC,gnomAD
rs928416631	p.His51Gln	missense variant	-	NC_000007.14:g.155298438C>A	TOPMed,gnomAD
rs1190283045	p.Ala53Val	missense variant	-	NC_000007.14:g.155298443C>T	gnomAD
rs780898112	p.Ala53Ser	missense variant	-	NC_000007.14:g.155298442G>T	ExAC,gnomAD
rs1407846667	p.Pro54Ala	missense variant	-	NC_000007.14:g.155298445C>G	TOPMed
rs1415715026	p.Pro54Leu	missense variant	-	NC_000007.14:g.155298446C>T	TOPMed
rs1448820452	p.Asp55Glu	missense variant	-	NC_000007.14:g.155298450C>A	gnomAD
rs989193457	p.Ala56Thr	missense variant	-	NC_000007.14:g.155298451G>A	TOPMed,gnomAD
rs755144116	p.Asp57Glu	missense variant	-	NC_000007.14:g.155298456C>G	ExAC,TOPMed,gnomAD
rs755144116	p.Asp57Glu	missense variant	-	NC_000007.14:g.155298456C>A	ExAC,TOPMed,gnomAD
rs567098938	p.Ala59Val	missense variant	-	NC_000007.14:g.155298461C>T	ExAC,gnomAD
rs772680330	p.Arg61Lys	missense variant	-	NC_000007.14:g.155298467G>A	ExAC,gnomAD
rs772680330	p.Arg61Thr	missense variant	-	NC_000007.14:g.155298467G>C	ExAC,gnomAD
rs773576456	p.Arg63Leu	missense variant	-	NC_000007.14:g.155298473G>T	ExAC,TOPMed,gnomAD
rs773576456	p.Arg63His	missense variant	-	NC_000007.14:g.155298473G>A	ExAC,TOPMed,gnomAD
rs771423871	p.Ser64Asn	missense variant	-	NC_000007.14:g.155298476G>A	ExAC,gnomAD
rs992348599	p.Ala65Val	missense variant	-	NC_000007.14:g.155298479C>T	TOPMed,gnomAD
rs1435064549	p.Ala65Thr	missense variant	-	NC_000007.14:g.155298478G>A	gnomAD
rs1313501864	p.Ala66Val	missense variant	-	NC_000007.14:g.155298482C>T	gnomAD
rs759297214	p.Glu71Lys	missense variant	-	NC_000007.14:g.155298496G>A	ExAC,gnomAD
rs759297214	p.Glu71Ter	stop gained	-	NC_000007.14:g.155298496G>T	ExAC,gnomAD
rs1453474977	p.Glu71Asp	missense variant	-	NC_000007.14:g.155298498G>C	TOPMed
rs1464253252	p.Gly73Arg	missense variant	-	NC_000007.14:g.155298502G>C	gnomAD
rs775118067	p.Ser74Ile	missense variant	-	NC_000007.14:g.155298506G>T	ExAC,gnomAD
rs762357555	p.Pro75Leu	missense variant	-	NC_000007.14:g.155298509C>T	ExAC,gnomAD
rs1431302565	p.Pro75Ser	missense variant	-	NC_000007.14:g.155298508C>T	gnomAD
rs764160755	p.Tyr76Cys	missense variant	-	NC_000007.14:g.155298512A>G	ExAC,TOPMed,gnomAD
rs761681762	p.Asn78Tyr	missense variant	-	NC_000007.14:g.155298517A>T	ExAC,gnomAD
rs371087646	p.Thr79Ser	missense variant	-	NC_000007.14:g.155298521C>G	ESP,ExAC,TOPMed,gnomAD
rs371087646	p.Thr79Ile	missense variant	-	NC_000007.14:g.155298521C>T	ESP,ExAC,TOPMed,gnomAD
rs199932909	p.His82Tyr	missense variant	-	NC_000007.14:g.155298529C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1385541141	p.Arg83Gly	missense variant	-	NC_000007.14:g.155298532C>G	TOPMed,gnomAD
rs755231844	p.Arg83Leu	missense variant	-	NC_000007.14:g.155298533G>T	ExAC,gnomAD
rs755231844	p.Arg83His	missense variant	-	NC_000007.14:g.155298533G>A	ExAC,gnomAD
rs1385541141	p.Arg83Cys	missense variant	-	NC_000007.14:g.155298532C>T	TOPMed,gnomAD
rs373597330	p.Leu85Met	missense variant	-	NC_000007.14:g.155298538T>A	ESP,TOPMed
rs1265830529	p.Ser88Asn	missense variant	-	NC_000007.14:g.155298548G>A	gnomAD
rs1265830529	p.Ser88Ile	missense variant	-	NC_000007.14:g.155298548G>T	gnomAD
NCI-TCGA novel	p.Leu91Arg	missense variant	-	NC_000007.14:g.155298557T>G	NCI-TCGA
NCI-TCGA novel	p.Phe92Leu	inframe deletion	-	NC_000007.14:g.155298561_155298563CTC>-	NCI-TCGA
rs1266928472	p.Val94Ile	missense variant	-	NC_000007.14:g.155298565G>A	gnomAD
rs1487476793	p.Val96Leu	missense variant	-	NC_000007.14:g.155298571G>T	gnomAD
rs1179233992	p.Val96Gly	missense variant	-	NC_000007.14:g.155298572T>G	gnomAD
NCI-TCGA novel	p.Leu98Arg	missense variant	-	NC_000007.14:g.155298578T>G	NCI-TCGA
rs1472350480	p.Leu102Pro	missense variant	-	NC_000007.14:g.155298590T>C	gnomAD
rs925490014	p.Leu102Phe	missense variant	-	NC_000007.14:g.155298589C>T	TOPMed
rs746215366	p.Asn103Ile	missense variant	-	NC_000007.14:g.155298593A>T	ExAC,gnomAD
rs911097384	p.Asn103His	missense variant	-	NC_000007.14:g.155298592A>C	TOPMed
rs202184874	p.Gln108Glu	missense variant	-	NC_000007.14:g.155298607C>G	1000Genomes
rs1456872000	p.Gln108Arg	missense variant	-	NC_000007.14:g.155298608A>G	gnomAD
rs200641765	p.Val111Ala	missense variant	-	NC_000007.14:g.155298617T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs762601697	p.Thr112Ile	missense variant	-	NC_000007.14:g.155298620C>T	ExAC,gnomAD
rs1175514792	p.Thr112Ala	missense variant	-	NC_000007.14:g.155298619A>G	TOPMed
rs773861240	p.Glu116Asp	missense variant	-	NC_000007.14:g.155298633G>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu117Lys	missense variant	-	NC_000007.14:g.155298634G>A	NCI-TCGA
rs761769847	p.Val118Met	missense variant	-	NC_000007.14:g.155298637G>A	ExAC,TOPMed,gnomAD
rs760447154	p.Ile119Met	missense variant	-	NC_000007.14:g.155298642C>G	ExAC,TOPMed,gnomAD
rs750266191	p.Ile119Phe	missense variant	-	NC_000007.14:g.155298640A>T	ExAC,gnomAD
rs765559868	p.Ala120Ser	missense variant	-	NC_000007.14:g.155298643G>T	ExAC,gnomAD
rs143931518	p.Ile122Val	missense variant	-	NC_000007.14:g.155298649A>G	ESP,ExAC,TOPMed,gnomAD
rs758584360	p.Ser124Ala	missense variant	-	NC_000007.14:g.155298655T>G	ExAC,gnomAD
rs1182629652	p.Ser125Phe	missense variant	-	NC_000007.14:g.155298659C>T	gnomAD
rs1480444374	p.Ser125Pro	missense variant	-	NC_000007.14:g.155298658T>C	gnomAD
rs1422416569	p.Trp127Ter	stop gained	-	NC_000007.14:g.155298666G>A	gnomAD
NCI-TCGA novel	p.Val129Gly	missense variant	-	NC_000007.14:g.155298671T>G	NCI-TCGA
rs1163583421	p.Pro130Leu	missense variant	-	NC_000007.14:g.155298674C>T	TOPMed,gnomAD
rs896145760	p.Gly134Val	missense variant	-	NC_000007.14:g.155298686G>T	TOPMed
rs1305663435	p.Ala136Val	missense variant	-	NC_000007.14:g.155298692C>T	gnomAD
NCI-TCGA novel	p.Ala137Thr	missense variant	-	NC_000007.14:g.155298694G>A	NCI-TCGA
rs1448351632	p.Ala138Thr	missense variant	-	NC_000007.14:g.155298697G>A	gnomAD
rs201333521	p.Gly141Val	missense variant	-	NC_000007.14:g.155301575G>T	1000Genomes
rs763128502	p.Cys146Tyr	missense variant	-	NC_000007.14:g.155301590G>A	ExAC,gnomAD
rs776434139	p.Cys146Arg	missense variant	-	NC_000007.14:g.155301589T>C	ExAC,gnomAD
rs1187004218	p.Ser149Gly	missense variant	-	NC_000007.14:g.155301598A>G	gnomAD
rs757412249	p.Gly152Arg	missense variant	-	NC_000007.14:g.155301607G>A	ExAC,gnomAD
NCI-TCGA novel	p.Pro154Leu	missense variant	-	NC_000007.14:g.155301614C>T	NCI-TCGA
NCI-TCGA novel	p.His155Arg	missense variant	-	NC_000007.14:g.155301617A>G	NCI-TCGA
rs972230362	p.Lys156Gln	missense variant	-	NC_000007.14:g.155301619A>C	TOPMed
COSM123756	p.Arg159Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155301629G>C	NCI-TCGA Cosmic
rs767640062	p.Glu160Ter	stop gained	-	NC_000007.14:g.155301631G>T	ExAC,gnomAD
rs767640062	p.Glu160Gln	missense variant	-	NC_000007.14:g.155301631G>C	ExAC,gnomAD
rs1210098134	p.Met165Leu	missense variant	-	NC_000007.14:g.155301646A>T	TOPMed
rs1355259052	p.Met165Thr	missense variant	-	NC_000007.14:g.155301647T>C	TOPMed
rs750982948	p.Arg166His	missense variant	-	NC_000007.14:g.155301650G>A	ExAC,gnomAD
NCI-TCGA novel	p.Arg166Leu	missense variant	-	NC_000007.14:g.155301650G>T	NCI-TCGA
rs115964577	p.Ile168Met	missense variant	-	NC_000007.14:g.155301657A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs1230066993	p.Val172Phe	missense variant	-	NC_000007.14:g.155301667G>T	TOPMed
rs116076329	p.Gly173Val	missense variant	-	NC_000007.14:g.155301671G>T	1000Genomes,gnomAD
rs116076329	p.Gly173Asp	missense variant	-	NC_000007.14:g.155301671G>A	1000Genomes,gnomAD
rs749633375	p.Ala177Thr	missense variant	-	NC_000007.14:g.155301682G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala179Val	missense variant	-	NC_000007.14:g.155301689C>T	NCI-TCGA
rs754211515	p.Asp182Tyr	missense variant	-	NC_000007.14:g.155302257G>T	ExAC,TOPMed,gnomAD
rs1230336149	p.Leu191Phe	missense variant	-	NC_000007.14:g.155302286G>T	gnomAD
COSM4926681	p.Gly199Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155302309G>A	NCI-TCGA Cosmic
rs747810129	p.Leu200Phe	missense variant	-	NC_000007.14:g.155302311C>T	ExAC,gnomAD
rs757992959	p.Thr203Ile	missense variant	-	NC_000007.14:g.155302321C>T	ExAC,TOPMed,gnomAD
rs527701821	p.Arg206Cys	missense variant	-	NC_000007.14:g.155302329C>T	-
rs548930206	p.Arg206His	missense variant	-	NC_000007.14:g.155302330G>A	ExAC,gnomAD
rs770836270	p.Ser207Thr	missense variant	-	NC_000007.14:g.155302332T>A	ExAC,TOPMed,gnomAD
rs1398230061	p.Ala218Thr	missense variant	-	NC_000007.14:g.155302365G>A	-
COSM745747	p.Leu220Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155302371C>G	NCI-TCGA Cosmic
rs769646258	p.Thr222Met	missense variant	-	NC_000007.14:g.155302378C>T	ExAC,TOPMed,gnomAD
rs1389700620	p.Ile224Ser	missense variant	-	NC_000007.14:g.155302384T>G	gnomAD
NCI-TCGA novel	p.Ile224Thr	missense variant	-	NC_000007.14:g.155302384T>C	NCI-TCGA
rs1278784292	p.Ile224Val	missense variant	-	NC_000007.14:g.155302383A>G	TOPMed
rs142687202	p.Thr225Met	missense variant	-	NC_000007.14:g.155302387C>T	ESP,ExAC,gnomAD
rs567627468	p.Gln226His	missense variant	-	NC_000007.14:g.155302391G>C	TOPMed,gnomAD
rs760796100	p.Phe227Leu	missense variant	-	NC_000007.14:g.155302394T>G	ExAC,gnomAD
NCI-TCGA novel	p.Phe227Cys	missense variant	-	NC_000007.14:g.155302393T>G	NCI-TCGA
rs200756620	p.Val229Met	missense variant	-	NC_000007.14:g.155302398G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs200756620	p.Val229Leu	missense variant	-	NC_000007.14:g.155302398G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs200756620	p.Val229Leu	missense variant	-	NC_000007.14:g.155302398G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs765610318	p.Val233Ala	missense variant	-	NC_000007.14:g.155302411T>C	ExAC,gnomAD
rs116500782	p.Tyr234Cys	missense variant	-	NC_000007.14:g.155302414A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1210422745	p.Thr237Ile	missense variant	-	NC_000007.14:g.155302752C>T	TOPMed
rs1245965554	p.Thr237Ala	missense variant	-	NC_000007.14:g.155302751A>G	gnomAD
NCI-TCGA novel	p.Leu242Phe	missense variant	-	NC_000007.14:g.155302766C>T	NCI-TCGA
rs376290152	p.Arg245Cys	missense variant	-	NC_000007.14:g.155302775C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser246Tyr	missense variant	-	NC_000007.14:g.155302779C>A	NCI-TCGA
COSM3879730	p.Leu248Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155302784C>A	NCI-TCGA Cosmic
COSM300701	p.Pro249Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155302788C>T	NCI-TCGA Cosmic
COSM485116	p.Ile251Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155302795A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Phe252Ile	missense variant	-	NC_000007.14:g.155302796T>A	NCI-TCGA
NCI-TCGA novel	p.Phe253Leu	missense variant	-	NC_000007.14:g.155302801C>A	NCI-TCGA
NCI-TCGA novel	p.Phe253Val	missense variant	-	NC_000007.14:g.155302799T>G	NCI-TCGA
NCI-TCGA novel	p.Gly255Glu	missense variant	-	NC_000007.14:g.155302806G>A	NCI-TCGA
rs780785188	p.Val257Ile	missense variant	-	NC_000007.14:g.155302811G>A	ExAC,TOPMed,gnomAD
rs1162539615	p.Thr258Met	missense variant	-	NC_000007.14:g.155302815C>T	TOPMed,gnomAD
rs1383243939	p.Arg264Ter	stop gained	-	NC_000007.14:g.155302832C>T	gnomAD
COSM745746	p.Met268Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000007.14:g.155302846G>A	NCI-TCGA Cosmic
rs756170771	p.Met268Val	missense variant	-	NC_000007.14:g.155302844A>G	ExAC,gnomAD
rs766006782	p.Gly269Cys	missense variant	-	NC_000007.14:g.155308241G>T	ExAC,gnomAD
rs753354869	p.Val270Ala	missense variant	-	NC_000007.14:g.155308245T>C	ExAC,gnomAD
rs375048290	p.Pro271Ser	missense variant	-	NC_000007.14:g.155308247C>T	ESP,ExAC,TOPMed,gnomAD
rs1210954558	p.Pro274Ser	missense variant	-	NC_000007.14:g.155308256C>T	gnomAD
NCI-TCGA novel	p.Pro274AlaPheSerTerUnk	frameshift	-	NC_000007.14:g.155308250_155308251insA	NCI-TCGA
rs765060506	p.Ter278Trp	stop lost	-	NC_000007.14:g.155308270A>G	ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0007097	Carcinoma	group	CTD_human
C0010054	Coronary Arteriosclerosis	disease	BEFREE
C0010068	Coronary heart disease	disease	BEFREE
C0010823	Cytomegalovirus Infections	group	BEFREE
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE
C0015695	Fatty Liver	disease	BEFREE;RGD
C0015696	Fatty Liver, Alcoholic	disease	RGD
C0020557	Hypertriglyceridemia	phenotype	BEFREE
C0023903	Liver neoplasms	group	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0024667	Animal Mammary Neoplasms	group	CTD_human
C0024668	Mammary Neoplasms, Experimental	group	CTD_human
C0028754	Obesity	disease	BEFREE
C0033578	Prostatic Neoplasms	group	BEFREE
C0038356	Stomach Neoplasms	group	LHGDN
C0205696	Anaplastic carcinoma	disease	CTD_human
C0205697	Carcinoma, Spindle-Cell	disease	CTD_human
C0205698	Undifferentiated carcinoma	phenotype	CTD_human
C0205699	Carcinomatosis	phenotype	CTD_human
C0338591	Amnesia, Transient Global	disease	BEFREE
C0400966	Non-alcoholic Fatty Liver Disease	disease	BEFREE
C0524620	Metabolic Syndrome X	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C1257925	Mammary Carcinoma, Animal	disease	CTD_human
C1956346	Coronary Artery Disease	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE
C2711227	Steatohepatitis	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005515	protein binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0006641	triglyceride metabolic process	IEA
GO:0006695	cholesterol biosynthetic process	IEA
GO:0010894	negative regulation of steroid biosynthetic process	IEA
GO:0032933	SREBP signaling pathway	IDA
GO:0036315	cellular response to sterol	IMP
GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	IDA
GO:0042472	inner ear morphogenesis	IEA
GO:0042474	middle ear morphogenesis	IEA
GO:0042632	cholesterol homeostasis	IDA
GO:0045599	negative regulation of fat cell differentiation	IEA
GO:0045717	negative regulation of fatty acid biosynthetic process	IEA
GO:0060021	roof of mouth development	IEA
GO:0060363	cranial suture morphogenesis	IEA
GO:0070862	negative regulation of protein exit from endoplasmic reticulum	IDA
GO:1901303	negative regulation of cargo loading into COPII-coated vesicle	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005783	endoplasmic reticulum	IDA
GO:0005789	endoplasmic reticulum membrane	TAS
GO:0032937	SREBP-SCAP-Insig complex	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	IEA
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-8957322	Metabolism of steroids	IEA

Drugs and compounds information

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in decreased expression of INSIG1 mRNA	19162173
D020001	1-Butanol	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of INSIG1 mRNA	28801915
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of INSIG1 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of INSIG1 mRNA	30723492
C078092	1-piperonylpiperazine	1-piperonylpiperazine results in increased expression of INSIG1 mRNA	26821219
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of INSIG1 mRNA	20453058
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether affects the expression of INSIG1 mRNA	31173147
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of INSIG1 mRNA	27291303
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of INSIG1 mRNA	21920950
C070055	2,3',4,4',5-pentachlorobiphenyl	2,3',4,4',5-pentachlorobiphenyl results in increased expression of INSIG1 mRNA	31388691
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of INSIG1 mRNA	19167446
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG1 mRNA	28433925
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of INSIG1 mRNA	21346803
C007997	25-hydroxycholesterol	[25-hydroxycholesterol co-treated with Cholesterol] promotes the reaction [SCAP protein binds to INSIG1 protein]	19716478
C007997	25-hydroxycholesterol	INSIG1 protein affects the reaction [25-hydroxycholesterol results in decreased cleavage of SREBF1 protein]	27324795
C007997	25-hydroxycholesterol	INSIG1 protein affects the reaction [25-hydroxycholesterol results in decreased expression of HMGCS1 mRNA]	27324795
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in decreased expression of INSIG1 mRNA	19260826
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of INSIG1 mRNA	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of INSIG1 mRNA	12376462
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone promotes the reaction [PPARG protein results in increased activity of INSIG1 promoter]]	15073165
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone promotes the reaction [RXRA protein results in increased activity of INSIG1 promoter]]	15073165
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of INSIG1 mRNA	29704546
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of INSIG1 mRNA	23146750
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of INSIG1 mRNA	29216392
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of INSIG1 mRNA	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of INSIG1 mRNA	19561079
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of INSIG1 mRNA	28073004
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of INSIG1 mRNA	20382639
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of INSIG1 mRNA	22079614
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene affects the expression of INSIG1 mRNA	21785161
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in decreased expression of INSIG1 mRNA	12376462
D000082	Acetaminophen	Acetaminophen results in decreased expression of INSIG1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of INSIG1 mRNA	17585979
D000082	Acetaminophen	Acetaminophen results in decreased expression of INSIG1 mRNA	30723492
D000082	Acetaminophen	Acetaminophen results in increased expression of INSIG1 mRNA	22112502
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of INSIG1 mRNA	22129741
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of INSIG1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of INSIG1 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of INSIG1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of INSIG1 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of INSIG1 mRNA	23630614
D000395	Air Pollutants, Occupational	Air Pollutants, Occupational results in increased expression of INSIG1 mRNA	23195993
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of INSIG1 mRNA	16483693
D000952	Antigens, Polyomavirus Transforming	Antigens, Polyomavirus Transforming results in decreased expression of INSIG1 mRNA	26680231
C519728	archazolid B	archazolid B results in increased expression of INSIG1 mRNA	25218289
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of INSIG1 mRNA	15894607
D000077237	Arsenic Trioxide	[Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of INSIG1 mRNA	15894607
D001241	Aspirin	Aspirin results in increased expression of INSIG1 mRNA	15928584
D001241	Aspirin	Aspirin results in increased expression of INSIG1 mRNA	12800193
D001280	Atrazine	Atrazine results in decreased expression of INSIG1 mRNA	25929836
C049935	avobenzone	avobenzone results in increased expression of INSIG1 mRNA	31016361
C004456	beauvericin	beauvericin results in increased expression of INSIG1 mRNA	29203277
D001507	Beclomethasone	Beclomethasone results in increased expression of INSIG1 mRNA	23656298
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in increased expression of INSIG1 mRNA	31199489
D001554	Benzene	Benzene affects the expression of INSIG1 mRNA	15878777
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of INSIG1 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of INSIG1 mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of INSIG1 mRNA	22228805
C044887	beta-methylcholine	beta-methylcholine affects the expression of INSIG1 mRNA	21179406
D000077610	Bexarotene	Bexarotene results in increased expression of INSIG1 mRNA	16648578
D001629	Bezafibrate	Bezafibrate results in increased expression of INSIG1 mRNA	17118139; 19124612;
C006780	bisphenol A	bisphenol A affects the expression of INSIG1 mRNA	21786754; 23557687;
C006780	bisphenol A	bisphenol A affects the expression of INSIG1 mRNA	20170705; 21826169;
C006780	bisphenol A	bisphenol A results in decreased methylation of INSIG1 promoter	30352284
C006780	bisphenol A	bisphenol A results in increased expression of INSIG1 mRNA	25047013; 29275510;
C006780	bisphenol A	bisphenol A affects the expression of INSIG1 mRNA	21932408
C006780	bisphenol A	bisphenol A results in increased expression of INSIG1 mRNA	21932408; 25270620;
C006780	bisphenol A	[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG1 mRNA	28433925
C006780	bisphenol A	bisphenol A affects the expression of INSIG1 mRNA	30903817
C006780	bisphenol A	bisphenol A results in decreased expression of INSIG1 mRNA	30816183
C006780	bisphenol A	bisphenol A results in increased expression of INSIG1 mRNA	12075121; 25181051; 29552716;
C006780	bisphenol A	bisphenol A results in increased expression of INSIG1 mRNA	28988043
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of INSIG1 mRNA	15728792
C038091	butylparaben	butylparaben results in decreased expression of INSIG1 mRNA	29458080
D020148	Butyric Acid	Butyric Acid results in increased expression of INSIG1 mRNA	12800193
C584509	C646 compound	C646 compound affects the expression of INSIG1 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of INSIG1 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of INSIG1 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of INSIG1 mRNA	19010381
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of INSIG1 mRNA	18654764
D002110	Caffeine	Caffeine results in decreased expression of INSIG1 mRNA	20864626; 25868845;
D002117	Calcitriol	Calcitriol results in increased expression of INSIG1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of INSIG1 mRNA	21592394
D002220	Carbamazepine	Carbamazepine affects the expression of INSIG1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of INSIG1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of INSIG1 mRNA	16239168
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of INSIG1 mRNA	22112502
D002330	Carmustine	Carmustine results in decreased expression of INSIG1 mRNA	15980968
C084597	chlorcyclizine	chlorcyclizine results in increased expression of INSIG1 mRNA	21058326
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of INSIG1 mRNA	25596134
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of INSIG1 mRNA	23650126
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of INSIG1 mRNA	21356183
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in increased expression of INSIG1 mRNA	21356183
D002784	Cholesterol	[25-hydroxycholesterol co-treated with Cholesterol] promotes the reaction [SCAP protein binds to INSIG1 protein]	19716478
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of INSIG1 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of INSIG1 mRNA	27344345
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of INSIG1 mRNA	30690063
D000077404	Cidofovir	Cidofovir results in increased expression of INSIG1 mRNA	25596134
D002922	Ciguatoxins	Ciguatoxins affects the expression of INSIG1 mRNA	18353800
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of INSIG1 mRNA	17178418
D002945	Cisplatin	Cisplatin affects the reaction [Piroxicam results in decreased expression of INSIG1 mRNA]	21858171
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of INSIG1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of INSIG1 mRNA	27594783
D002990	Clobetasol	Clobetasol results in increased expression of INSIG1 mRNA	27462272
D002994	Clofibrate	Clofibrate results in increased expression of INSIG1 mRNA	12851107; 17126302;
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of INSIG1 mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in increased expression of INSIG1 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of INSIG1 mRNA	24386269
D005576	Colforsin	AR protein promotes the reaction [Colforsin results in increased expression of INSIG1 protein]	16751804
D005576	Colforsin	Colforsin results in increased expression of INSIG1 mRNA	16751804
D005576	Colforsin	Colforsin results in increased expression of INSIG1 protein	16751804
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in increased expression of INSIG1 mRNA	21356183
D003300	Copper	Copper results in increased expression of INSIG1 mRNA	21356183
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of INSIG1 mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of INSIG1 mRNA	20971185
D003300	Copper	Copper results in decreased expression of INSIG1 mRNA	30556269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of INSIG1 mRNA	21595052
D019327	Copper Sulfate	Copper Sulfate results in increased expression of INSIG1 mRNA	19549813
D003375	Coumestrol	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of INSIG1 mRNA	19167446
D003375	Coumestrol	[Coumestrol co-treated with Resveratrol] results in increased expression of INSIG1 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of INSIG1 mRNA	19167446
D000077547	Crizotinib	Crizotinib results in increased expression of INSIG1 mRNA	23707608
C030973	cupric oxide	cupric oxide results in increased expression of INSIG1 mRNA	22077320
D003471	Cuprizone	Cuprizone results in decreased expression of INSIG1 mRNA	27523638
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of INSIG1 mRNA	17383702
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of INSIG1 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of INSIG1 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of INSIG1 mRNA	25596134; 27989131;
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of INSIG1 mRNA	24921660
C093628	cyproconazole	cyproconazole results in increased expression of INSIG1 mRNA	22045034
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of INSIG1 mRNA	23640034
D000077209	Decitabine	Decitabine results in decreased expression of INSIG1 mRNA	19194470
D003897	Desmosterol	Desmosterol results in decreased expression of INSIG1 protein	19260826
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of INSIG1 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in decreased expression of INSIG1 mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of INSIG1 mRNA	15728792; 21266533; 21745491;
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of INSIG1 mRNA	26924002
D004041	Dietary Fats	Dietary Fats affects the expression of INSIG1 mRNA	19680557
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of INSIG1 mRNA	28433925
D004041	Dietary Fats	[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG1 mRNA	29852127
D004041	Dietary Fats	Dietary Fats results in decreased expression of INSIG1 mRNA	18042831; 22609946; 30120929;
D004041	Dietary Fats	[Rosiglitazone co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of INSIG1 mRNA	28611668
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of INSIG1 mRNA	28433925
D000073417	Dietary Sugars	[Rosiglitazone co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of INSIG1 mRNA	28611668
D004051	Diethylhexyl Phthalate	[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG1 mRNA	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of INSIG1 mRNA	15728792
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of INSIG1 mRNA	22129741
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of INSIG1 mRNA	29458080
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of INSIG1 mRNA	29581250
C025605	diisobutyl phthalate	diisobutyl phthalate results in increased expression of INSIG1 mRNA	29458080
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of INSIG1 mRNA	26924002
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in decreased expression of INSIG1 mRNA	15728792
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of INSIG1 mRNA	24690739
C012301	domoic acid	domoic acid results in increased expression of INSIG1 mRNA	18936300
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
D004317	Doxorubicin	Doxorubicin results in decreased expression of INSIG1 mRNA	29803840
D004726	Endosulfan	Endosulfan affects the expression of INSIG1 mRNA	29391264
C118739	entinostat	entinostat results in decreased expression of INSIG1 mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of INSIG1 mRNA	20064776
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of INSIG1 mRNA	22079256
D004958	Estradiol	Estradiol affects the expression of INSIG1 mRNA	21826169
D004958	Estradiol	Estradiol results in increased expression of INSIG1 mRNA	19167446
D004958	Estradiol	Estradiol results in decreased expression of INSIG1 mRNA	19484750
D000431	Ethanol	Ethanol results in increased expression of INSIG1 mRNA	29361514
D000431	Ethanol	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D000431	Ethanol	Ethanol affects the expression of INSIG1 mRNA	30319688
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of INSIG1 mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of INSIG1 mRNA	29458080
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of INSIG1 mRNA	20170705; 26865667;
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of INSIG1 mRNA	18936297
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of INSIG1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of INSIG1 mRNA	15901920; 17108234;
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of INSIG1 mRNA	23649840
D005038	Ethylnitrosourea	Ethylnitrosourea results in decreased expression of INSIG1 mRNA	15954086
D005047	Etoposide	INSIG1 protein affects the susceptibility to Etoposide	16217747
C545733	fatostatin	fatostatin results in decreased expression of INSIG1 mRNA	19716478; 24493696; 26512780; 29436682;
C545733	fatostatin	[TP53 protein mutant form results in increased susceptibility to fatostatin] promotes the reaction [fatostatin results in decreased expression of INSIG1 mRNA]	26512780
D005228	Fatty Acids, Essential	Fatty Acids, Essential deficiency results in increased expression of INSIG1 mRNA	23333450
D011345	Fenofibrate	Fenofibrate results in decreased expression of INSIG1 mRNA	25572481
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of INSIG1 mRNA	17347304
C007738	fluoranthene	fluoranthene results in decreased expression of INSIG1 mRNA	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of INSIG1 mRNA	17039268
D005473	Fluoxetine	Fluoxetine results in increased expression of INSIG1 mRNA	21852994
C061365	flusilazole	flusilazole affects the expression of INSIG1 mRNA	21195148; 22634333;
D005485	Flutamide	Flutamide results in decreased expression of INSIG1 mRNA	21126777
D005485	Flutamide	Flutamide results in decreased expression of INSIG1 mRNA	24136188
D005492	Folic Acid	Folic Acid results in increased expression of INSIG1 mRNA	11723236
D005557	Formaldehyde	Formaldehyde results in decreased expression of INSIG1 mRNA	23649840
D005632	Fructose	Fructose results in decreased expression of INSIG1 protein	22698815
D005632	Fructose	Fructose results in increased expression of INSIG1 mRNA	22698815
D005632	Fructose	Phenylbutyrates inhibits the reaction [Fructose results in decreased expression of INSIG1 protein]	22698815
C039281	furan	furan results in increased expression of INSIG1 mRNA	24183702; 24910943;
C515005	ganoderic acid A	ganoderic acid A results in decreased expression of INSIG1 mRNA	29852127
D005742	Gasoline	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D005742	Gasoline	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D005742	Gasoline	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D005742	Gasoline	[Gasoline results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
C106014	gedunin	gedunin results in increased expression of INSIG1 mRNA	17010675
C056507	gemcitabine	gemcitabine results in increased expression of INSIG1 mRNA	17039268
D019833	Genistein	Genistein results in increased expression of INSIG1 mRNA	18847459; 26865667;
D019833	Genistein	Genistein results in increased expression of INSIG1 mRNA	28988043
C000593030	GSK-J4	GSK-J4 results in increased expression of INSIG1 mRNA	29301935
D006220	Haloperidol	Haloperidol results in increased expression of INSIG1 mRNA	29458080
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of INSIG1 mRNA	30594549
C409722	hexaconazole	hexaconazole affects the expression of INSIG1 mRNA	21195148
D006861	Hydrogen Peroxide	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA	18032389
D007052	Ibuprofen	Ibuprofen results in increased expression of INSIG1 mRNA	25596134
C492448	ICG 001	ICG 001 results in decreased expression of INSIG1 mRNA	26191083
C545476	incobotulinumtoxinA	incobotulinumtoxinA results in increased expression of INSIG1 mRNA	29522793
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of INSIG1 mRNA	22129741
D007213	Indomethacin	Indomethacin results in increased expression of INSIG1 mRNA	28201806
D000077146	Irinotecan	Irinotecan analog results in decreased expression of INSIG1 mRNA	18927307
C040507	isobutyl alcohol	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D007529	Isoflavones	Isoflavones affects the expression of INSIG1 mRNA	16365062
D007529	Isoflavones	Isoflavones results in increased expression of INSIG1 mRNA	17374662
C016527	isoquercitrin	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA	18032389
D015474	Isotretinoin	Isotretinoin results in decreased expression of INSIG1 mRNA	20436886
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of INSIG1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of INSIG1 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of INSIG1 mRNA	15618438
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of INSIG1 mRNA	25307878
D019344	Lactic Acid	Lactic Acid results in increased expression of INSIG1 mRNA	30851411
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of INSIG1 mRNA	18654764
D000077339	Leflunomide	Leflunomide results in increased expression of INSIG1 mRNA	24136188
C018584	linalool	linalool results in increased expression of INSIG1 protein	21944868
C482199	lipopolysaccharide, E coli O55-B5	lipopolysaccharide, E coli O55-B5 results in decreased expression of INSIG1 mRNA	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of INSIG1 mRNA	25613284
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of INSIG1 mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG1 mRNA]	16415329
D008148	Lovastatin	Lovastatin results in increased expression of INSIG1 mRNA	19260826
D008148	Lovastatin	[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG1 mRNA	29852127
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of INSIG1 mRNA	21641980
C025340	manganese chloride	manganese chloride results in decreased expression of INSIG1 mRNA	28801915
C025340	manganese chloride	manganese chloride results in increased methylation of INSIG1 gene	28801915
C042720	mercuric bromide	mercuric bromide results in decreased expression of INSIG1 mRNA	26272509
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
D008687	Metformin	Metformin results in increased expression of INSIG1 mRNA	23457588
D008694	Methamphetamine	Methamphetamine affects the expression of INSIG1 mRNA	29802913
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of INSIG1 mRNA	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of INSIG1 mRNA	19465457
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of INSIG1 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of INSIG1 mRNA	23649840
D008777	Methyltestosterone	Methyltestosterone results in increased expression of INSIG1 mRNA	29458080
D015741	Metribolone	Metribolone results in increased expression of INSIG1 mRNA	16751804
D015741	Metribolone	Metribolone results in increased expression of INSIG1 protein	16751804
D008825	Miconazole	Miconazole results in increased expression of INSIG1 mRNA	27462272
C059539	midostaurin	midostaurin results in increased expression of INSIG1 mRNA	20980353
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of INSIG1 mRNA	23876855
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of INSIG1 mRNA	26924002
C561240	N-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenyl)methanesulfonamide	N-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenyl)methanesulfonamide results in decreased expression of INSIG1 mRNA	21561152
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of INSIG1 mRNA	16052530
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of INSIG1 mRNA	24389112
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of INSIG1 mRNA	25554681; 25620056;
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of INSIG1 mRNA	25620056
C461488	N-benzylpiperazine	N-benzylpiperazine results in increased expression of INSIG1 mRNA	26821219
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of INSIG1 mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of INSIG1 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of INSIG1 mRNA	24768652
D009532	Nickel	Nickel results in increased expression of INSIG1 mRNA	23195993
D009534	Niclosamide	Niclosamide results in decreased expression of INSIG1 mRNA	31398420
D009538	Nicotine	Nicotine results in increased expression of INSIG1 mRNA	23416264
D009538	Nicotine	Nicotine results in decreased expression of INSIG1 mRNA	26776438
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of INSIG1 mRNA	19716841
C570896	NSC305787	NSC305787 results in increased expression of INSIG1 mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of INSIG1 mRNA	20971185
D000077150	Oxaliplatin	Oxaliplatin results in decreased expression of INSIG1 mRNA	16510598
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of INSIG1 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of INSIG1 mRNA	25596134
D017239	Paclitaxel	INSIG1 protein affects the susceptibility to Paclitaxel	16217747
D000073878	Palm Oil	Palm Oil affects the expression of INSIG1 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of INSIG1 mRNA	18042831
D052638	Particulate Matter	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D052638	Particulate Matter	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D052638	Particulate Matter	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D052638	Particulate Matter	[Gasoline results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D052638	Particulate Matter	Particulate Matter results in increased expression of INSIG1 mRNA	23085030
D020245	p-Chloromercuribenzoic Acid	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of INSIG1 mRNA	26272509
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of INSIG1 mRNA	18593933
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of INSIG1 mRNA	24642059
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of INSIG1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of INSIG1 protein	25092180
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of INSIG1 mRNA	19162173
D010629	Phenformin	Phenformin results in decreased expression of INSIG1 mRNA	31324951
D010634	Phenobarbital	Phenobarbital results in decreased expression of INSIG1 mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of INSIG1 mRNA	19162173
D010654	Phenylbutyrates	Phenylbutyrates inhibits the reaction [Fructose results in decreased expression of INSIG1 protein]	22698815
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INSIG1 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of INSIG1 mRNA	26272509
C014153	pirimiphos methyl	pirimiphos methyl results in decreased expression of INSIG1 mRNA	27845199
C006253	pirinixic acid	pirinixic acid results in decreased expression of INSIG1 mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of INSIG1 mRNA	17118139
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of INSIG1 protein	19248225
C006253	pirinixic acid	pirinixic acid results in increased expression of INSIG1 mRNA	17126302; 19162173;
D010894	Piroxicam	Cisplatin affects the reaction [Piroxicam results in decreased expression of INSIG1 mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of INSIG1 mRNA	21858171
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D011084	Polycyclic Aromatic Hydrocarbons	[Gasoline results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of INSIG1 mRNA	29432896
D011137	Polystyrenes	Polystyrenes results in decreased expression of INSIG1 mRNA	25102311
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of INSIG1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of INSIG1 mRNA	22079256; 22714537;
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of INSIG1 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of INSIG1 mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of INSIG1 mRNA	18070364
C045950	propiconazole	[propiconazole co-treated with tebuconazole] results in increased expression of INSIG1 mRNA	30989312
C045950	propiconazole	propiconazole results in increased expression of INSIG1 mRNA	30989312
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of INSIG1 mRNA	24780913; 25825206;
C502851	quinocetone	quinocetone results in increased expression of INSIG1 mRNA	27046791
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of INSIG1 mRNA	16497877
D011899	Ranitidine	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG1 mRNA]	16415329
D000074262	Rapeseed Oil	Rapeseed Oil metabolite results in decreased expression of INSIG1 mRNA	27363782
D000074262	Rapeseed Oil	Starch analog inhibits the reaction [Rapeseed Oil metabolite results in decreased expression of INSIG1 mRNA]	27363782
D000077185	Resveratrol	Resveratrol results in decreased expression of INSIG1 mRNA	25866375
D000077185	Resveratrol	[Coumestrol co-treated with Resveratrol] results in increased expression of INSIG1 mRNA	19167446
D000077154	Rosiglitazone	Rosiglitazone results in decreased expression of INSIG1 mRNA	25572481
D000077154	Rosiglitazone	[Rosiglitazone co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of INSIG1 mRNA	28611668
D000077154	Rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone promotes the reaction [PPARG protein results in increased activity of INSIG1 promoter]]	15073165
D000077154	Rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone promotes the reaction [RXRA protein results in increased activity of INSIG1 promoter]]	15073165
D000077154	Rosiglitazone	Rosiglitazone promotes the reaction [PPARG protein results in increased activity of INSIG1 promoter]	15073165
D000077154	Rosiglitazone	Rosiglitazone promotes the reaction [RXRA protein results in increased activity of INSIG1 promoter]	15073165
D012402	Rotenone	Rotenone results in decreased expression of INSIG1 mRNA	28374803
D012524	Sarin	Sarin results in decreased expression of INSIG1 mRNA	19522546
D012524	Sarin	Sarin results in increased expression of INSIG1 mRNA	19522546
C115461	SC 560	SC 560 results in decreased expression of INSIG1 mRNA	14633654
C551534	SGA 360	SGA 360 results in decreased expression of INSIG1 mRNA	31225620
C551534	SGA 360	SGA 360 results in increased expression of INSIG1 protein	31225620
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of INSIG1 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of INSIG1 mRNA	25351596
D020123	Sirolimus	[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of INSIG1 mRNA	25307878
C017947	sodium arsenite	sodium arsenite results in decreased expression of INSIG1 mRNA	29361514
C017947	sodium arsenite	sodium arsenite results in decreased expression of INSIG1 mRNA	12679051
C017947	sodium arsenite	sodium arsenite results in increased expression of INSIG1 mRNA	16966095; 28595984;
C016104	sodium bichromate	sodium bichromate results in decreased expression of INSIG1 mRNA	24612858
D013213	Starch	Starch analog inhibits the reaction [Rapeseed Oil metabolite results in decreased expression of INSIG1 mRNA]	27363782
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of INSIG1 mRNA	21641980
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of INSIG1 mRNA	12734198
D000077210	Sunitinib	Sunitinib results in increased expression of INSIG1 mRNA	31533062
C013698	tallow	tallow affects the expression of INSIG1 mRNA	19680557
C087114	tebuconazole	[propiconazole co-treated with tebuconazole] results in increased expression of INSIG1 mRNA	30989312
C087114	tebuconazole	tebuconazole results in increased expression of INSIG1 mRNA	30458266; 30989312;
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of INSIG1 mRNA	15336504
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of INSIG1 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of INSIG1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of INSIG1 mRNA	21998131
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of INSIG1 mRNA	12377990; 16704738;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of INSIG1 mRNA	21570461; 28922406;
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG1 mRNA	28433925
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of INSIG1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of INSIG1 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of INSIG1 mRNA	20558275
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of INSIG1 mRNA	16010555
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of INSIG1 mRNA	28973375
D019284	Thapsigargin	Thapsigargin results in decreased expression of INSIG1 mRNA	22378314
D019284	Thapsigargin	Thapsigargin results in increased expression of INSIG1 mRNA	29453283
D013849	Thimerosal	Thimerosal results in decreased expression of INSIG1 mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in increased expression of INSIG1 mRNA	29264374
D019772	Topotecan	INSIG1 protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of INSIG1 mRNA	25729387
C496197	trans-10,cis-12-conjugated linoleic acid	trans-10,cis-12-conjugated linoleic acid results in decreased expression of INSIG1 mRNA	16988111
C496197	trans-10,cis-12-conjugated linoleic acid	trans-10,cis-12-conjugated linoleic acid results in increased expression of INSIG1 mRNA	17951470
D014212	Tretinoin	[Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of INSIG1 mRNA	15894607
D014212	Tretinoin	Tretinoin results in decreased expression of INSIG1 mRNA	15894607
C032910	triadimefon	triadimefon affects the expression of INSIG1 mRNA	21195148
C012589	trichostatin A	trichostatin A affects the expression of INSIG1 mRNA	28542535
D014284	Triiodothyronine	Triiodothyronine results in increased expression of INSIG1 mRNA	15953391
C050414	tripterine	tripterine results in increased expression of INSIG1 mRNA	17010675
D000077288	Troglitazone	Troglitazone results in decreased expression of INSIG1 mRNA	25572481
D000077288	Troglitazone	[Troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of INSIG1 protein	19248225
D014415	Tunicamycin	Tunicamycin results in decreased expression of INSIG1 mRNA	22378314; 29453283;
D014501	Uranium	Uranium affects the expression of INSIG1 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of INSIG1 mRNA	15672453
D014635	Valproic Acid	Valproic Acid affects the expression of INSIG1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of INSIG1 mRNA	23179753; 25192806; 27188386; 28001369; 29154799;
D014635	Valproic Acid	Valproic Acid results in decreased methylation of INSIG1 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of INSIG1 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in decreased expression of INSIG1 mRNA	22045034
D014639	Vanadium	Vanadium results in decreased expression of INSIG1 mRNA	19000753
D014640	Vancomycin	Vancomycin results in increased expression of INSIG1 mRNA	18930951
C100058	vanillin	vanillin results in decreased expression of INSIG1 mRNA	17178418
C025643	vinclozolin	vinclozolin results in decreased expression of INSIG1 mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of INSIG1 mRNA	22570695
D014752	Vinyl Chloride	Vinyl Chloride results in increased expression of INSIG1 mRNA	18579281
D000077337	Vorinostat	Vorinostat results in decreased expression of INSIG1 mRNA	27188386
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of INSIG1 mRNA	18593933
D015034	Zinc Oxide	Zinc Oxide affects the expression of INSIG1 protein	28648595
D000077211	Zoledronic Acid	Zoledronic Acid results in increased expression of INSIG1 mRNA	24714768; 25596134;

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0025	Alternative splicing
KW-0153	Cholesterol metabolism
KW-0903	Direct protein sequencing
KW-0256	Endoplasmic reticulum
KW-1017	Isopeptide bond
KW-0443	Lipid metabolism
KW-0472	Membrane
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0753	Steroid metabolism
KW-1207	Sterol metabolism
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0832	Ubl conjugation

Interpro

InterPro ID	InterPro Term
IPR009904	INSIG-1
IPR025929	INSIG_fam

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF07281	INSIG

Gene: INSIG1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction