Gene: INSIG1

Basic information

Tag Content
Uniprot ID H2QVN6; A0A2J8KLS7;
Entrez ID 463839
Genbank protein ID JAA28076.1; JAA33455.1; JAA21597.1; JAA05651.1;
Genbank nucleotide ID XM_001145726.5
Ensembl protein ID ENSPTRP00000034091
Ensembl nucleotide ID ENSPTRG00000019905
Gene name Insulin-induced gene protein
Gene symbol INSIG1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Mediates feedback control of cholesterol synthesis.
Sequence
MPRLHDHFWS CSRAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP 60
RGRSAAMSGP EPGSPYPNTW HHRLVQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA 120
TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK 180
LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD 240
FLYIRSWLPC IFFSGGVTVG NIGRQLAMGV PEKPHSD 277

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologINSIG1511899A0JNC3Bos taurusPredictionMore>>
1:1 orthologINSIG1475554A0A5F4D7Y9Canis lupus familiarisPredictionMore>>
1:1 orthologINSIG1A0A452FSS4Capra hircusPredictionMore>>
1:1 orthologINSIG1100065774A0A3Q2HPQ1Equus caballusPredictionMore>>
1:1 orthologINSIG13638O15503Homo sapiensPredictionMore>>
1:1 orthologInsig1231070Q8BGI3CPOMus musculusPublicationMore>>
1:1 orthologINSIG1463839H2QVN6Pan troglodytesPredictionMore>>
1:1 orthologinsig1334189Q8AV61Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0032937 SREBP-SCAP-Insig complex
GO:0006695 cholesterol biosynthetic process
GO:0042632 cholesterol homeostasis
GO:0060363 cranial suture morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:1901303 negative regulation of cargo loading into COPII-coated vesicle
GO:0045599 negative regulation of fat cell differentiation
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0070862 negative regulation of protein exit from endoplasmic reticulum
GO:0010894 negative regulation of steroid biosynthetic process
GO:0060021 roof of mouth development
GO:0032933 SREBP signaling pathway
GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum
GO:0006641 triglyceride metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0153 Cholesterol metabolism
KW-0256 Endoplasmic reticulum
KW-0443 Lipid metabolism
KW-0472 Membrane
KW-1185 Reference proteome
KW-0753 Steroid metabolism
KW-1207 Sterol metabolism
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR009904 INSIG-1
IPR025929 INSIG_fam

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07281 INSIG