| Tag | Content |
|---|---|
| Uniprot ID | A0A5F4D7Y9 |
| Entrez ID | 475554 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005629705.2 |
| Ensembl protein ID | ENSCAFP00000061892 |
| Ensembl nucleotide ID | ENSCAFG00000005081 |
| Gene name | Insulin-induced gene protein |
| Gene symbol | INSIG1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates feedback control of cholesterol synthesis. |
| Sequence | MPRLDDHCWS CSCAQGARHR GLPVAGAGGL AAKVGDMLSP AALAARRGPD PAPAHGPRSP 60 GAGGARGAGG GSPGSWHHHL VRRSLVLFSV GVVLALVLNL LQVQRNVTLF PEEVIATIFS 120 SAWWVPPCCG TAAAVVGLLY PCIDSHLGEP HKFKREWASV MRCVAVFVGI NHASAKLDFA 180 NNVQLSLTLA ALSLGLWWTF DRSRSGLGLG ITIAFLATLI TQLLVYNGVY QYTSPDFLYI 240 RSWLPCIFFS GGVTVGNIGR QLAMGVPEKP HSD 273 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INSIG1 | 511899 | A0JNC3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | 475554 | A0A5F4D7Y9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | A0A452FSS4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | INSIG1 | 100065774 | A0A3Q2HPQ1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | 3638 | O15503 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Insig1 | 231070 | Q8BGI3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | INSIG1 | 463839 | H2QVN6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | insig1 | 334189 | Q8AV61 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005789 | endoplasmic reticulum membrane |
| GO:0016021 | integral component of membrane |
| GO:0008203 | cholesterol metabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF07281 | INSIG |