| Tag | Content |
|---|---|
| Uniprot ID | A0JNC3 |
| Entrez ID | 511899 |
| Genbank protein ID | AAI26611.1 |
| Genbank nucleotide ID | NM_001077909.1 |
| Ensembl protein ID | ENSBTAP00000002084; ENSBTAP00000065040; |
| Ensembl nucleotide ID | ENSBTAG00000001592 |
| Gene name | Insulin-induced gene 1 protein |
| Gene symbol | INSIG1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. |
| Sequence | MPRLDDHLWR GPCAKGTKHR SHPRASARGL VAKAGEMINS SGSGPSLLAA HGALGTDPAH 60 GPQSAGVGGQ GSSSHVNSWH HHLVQRSLVL FSVGVVLALV LNLLQVQRNV TLFPDEVIAT 120 IFSSAWWVPP CCGTAAAVVG LLYPCIDSHL GEPHKFKREW ASVMRCVAVF VGINHASAKL 180 DFANNVQLSL TLAALSLGLW WTFDRSRSGL GLGITIAFLA TLITQLLVYN GVYQYTSPDF 240 LYIRSWLPCI FFSGGVTVGN IGRQLAMGVP EKPHSD 276 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INSIG1 | 511899 | A0JNC3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | 475554 | A0A5F4D7Y9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | A0A452FSS4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | INSIG1 | 100065774 | A0A3Q2HPQ1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | 3638 | O15503 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Insig1 | 231070 | Q8BGI3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | INSIG1 | 463839 | H2QVN6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | insig1 | 334189 | Q8AV61 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0032937 | SREBP-SCAP-Insig complex |
| GO:0006695 | cholesterol biosynthetic process |
| GO:0042632 | cholesterol homeostasis |
| GO:0060363 | cranial suture morphogenesis |
| GO:0042472 | inner ear morphogenesis |
| GO:0042474 | middle ear morphogenesis |
| GO:1901303 | negative regulation of cargo loading into COPII-coated vesicle |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0045717 | negative regulation of fatty acid biosynthetic process |
| GO:0070862 | negative regulation of protein exit from endoplasmic reticulum |
| GO:0010894 | negative regulation of steroid biosynthetic process |
| GO:0060021 | roof of mouth development |
| GO:0032933 | SREBP signaling pathway |
| GO:0036316 | SREBP-SCAP complex retention in endoplasmic reticulum |
| GO:0006641 | triglyceride metabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF07281 | INSIG |