| Tag | Content |
|---|---|
| Uniprot ID | Q8AV61 |
| Entrez ID | 334189 |
| Genbank protein ID | AAH45341.1; AAN28327.1; |
| Genbank nucleotide ID | NM_199869.1 |
| Ensembl protein ID | ENSDARP00000147776; ENSDARP00000018378; |
| Ensembl nucleotide ID | ENSDARG00000010658; ENSDARG00000113413; |
| Gene name | Insulin-induced gene 1 protein |
| Gene symbol | insig1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of scap and degradation of hmgcr. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with scap and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with scap, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing scap from escorting SREBPs to the Golgi. Sterol deprivation reduces oxysterol-binding, disrupting the interaction between insig1 and scap, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of hmgcr. |
| Sequence | MPRLEEHCWS CSCSTSVKTK DLSSAGWIVC KTGEMMSIIT SVLSHAYGSL HSLQSANLIR 60 RGLVLFIVGV VLALVLNLLQ IQRNVTLFPE EVLDTLFSSA WWIPLCCGTA AAVVGLLYPC 120 LDHHLGEPHK FKREWASVMR CIAVFVGINH ASAKLDFANN VQLSLTLAAL SLGLWWTFDR 180 SRSGFGLGLT TALLATLIAQ LLVYNGIYQY TSPDFLYVRS WLPCIFFSGG VTVGNIGRQL 240 AMGSTEKIHN D 251 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INSIG1 | 511899 | A0JNC3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | 475554 | A0A5F4D7Y9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | A0A452FSS4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | INSIG1 | 100065774 | A0A3Q2HPQ1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | INSIG1 | 3638 | O15503 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Insig1 | 231070 | Q8BGI3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | INSIG1 | 463839 | H2QVN6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | insig1 | 334189 | Q8AV61 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005783 | endoplasmic reticulum |
| GO:0032937 | SREBP-SCAP-Insig complex |
| GO:0008142 | oxysterol binding |
| GO:0032869 | cellular response to insulin stimulus |
| GO:0006695 | cholesterol biosynthetic process |
| GO:0032933 | SREBP signaling pathway |
| GO:0036316 | SREBP-SCAP complex retention in endoplasmic reticulum |
| GO:0016126 | sterol biosynthetic process |
| Pfam ID | Pfam Term |
|---|---|
| PF07281 | INSIG |