| Tag | Content |
|---|---|
| Uniprot ID | A0A452G0L9 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000030153 |
| Ensembl nucleotide ID | ENSCHIG00000025000 |
| Gene name | Cellular tumor antigen p53 |
| Gene symbol | TP53 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. |
| Sequence | MEESQAELGV EPPLSQETFS DLWNLKGRFT AQTPITLPHR EDVVTWLDEC PNEAPQMPEP 60 PAQAALAPAT SWPLSSFVPS QKTYPGNYGF RLGFLHSGTA KSVTCTYSPS LNKLFCQLAK 120 TCPVQLWVDS PPPPGTRVRA MAIYKKLEHM TEVVRRCPHH ERSSDYSDGL APPQHLIRVE 180 GNLRAEYFDD RNTFRHSVVV PYESPEIESE CTTIHYNFMC NSSCMGGMNR RPILTIITLE 240 DSRGNLLGRN SFEVRVCACP GRDRRTEEEN FRKKGQSCPE PPPGSTKRAL PSSTSSSPQQ 300 KKKPLDGEYF TLQIRGRKRF EMFRELNEAL ELMDAQAGRE PGESRAHSSH LKSKKGPSPS 360 CHKKPMLKRE GPDSD 375 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP53 | 281542 | P67939 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP53 | A0A452G0L9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP53 | 7157 | P04637 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tp53 | 22059 | P02340 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP53 | 455214 | H2QC53 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TP53 | G1SEU0 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tp53 | M0R497 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tp53 | 30590 | G1K2L5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0046872 | metal ion binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0006915 | apoptotic process |
| GO:0007049 | cell cycle |
| GO:0051262 | protein tetramerization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |