| Tag | Content |
|---|---|
| Uniprot ID | G1SEU0 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSOCUP00000000989 |
| Ensembl nucleotide ID | ENSOCUG00000001138 |
| Gene name | Cellular tumor antigen p53 |
| Gene symbol | TP53 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. |
| Sequence | MEESQSDLSL EPPLSQETFS DLWKLLPENN LLTTSLNPPV DDLLSAEDVA NWLNEDPEEG 60 LRVPAAPAPE APAPAAPALA APAPATSWPL SSSVPSQKTY HGNYGFRLGF LHSGTAKSVT 120 CTYSPCLNKL FCQLAKTCPV QLWVDSTPPP GSRVRAMAIY KKSQHMTEVV RRCPHHERCS 180 DSDGLAPPQH LIRVEGNLRA EYLDDRNTFR HSVVVPYEPP EVGSDCTTIH YNYMCNSSCM 240 GGMNRRPILT IITLEDSSGN LLGRNSFEVR VCACPGRDRR TEEENFRKKG EPCPELPPGS 300 SKRALPTTTT DSSPQTKKKP LDGEYFILKI RGRERFEMFR ELNEALELKD AQAEKEPGGS 360 RAHSSYLKAK KGQSTSRHKK PMFKREGPDS D 391 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP53 | 281542 | P67939 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP53 | A0A452G0L9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP53 | 7157 | P04637 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tp53 | 22059 | P02340 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP53 | 455214 | H2QC53 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TP53 | G1SEU0 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tp53 | M0R497 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tp53 | 30590 | G1K2L5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0046872 | metal ion binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0006915 | apoptotic process |
| GO:0007049 | cell cycle |
| GO:0051262 | protein tetramerization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |