| Tag | Content |
|---|---|
| Uniprot ID | M0R497 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000064177 |
| Ensembl nucleotide ID | ENSRNOG00000046657 |
| Gene name | Cellular tumor antigen p53 |
| Gene symbol | Tp53 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. |
| Sequence | MSFLHTLTAK SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT 60 EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT 120 TIHYNYMCNS SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR 180 KKGEPHHELP PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL 240 KDAQAGKEPG GSRAHSSHLK S 261 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP53 | 281542 | P67939 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP53 | A0A452G0L9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP53 | 7157 | P04637 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tp53 | 22059 | P02340 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP53 | 455214 | H2QC53 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TP53 | G1SEU0 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tp53 | M0R497 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tp53 | 30590 | G1K2L5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0046872 | metal ion binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0006915 | apoptotic process |
| GO:0007049 | cell cycle |
| GO:0051262 | protein tetramerization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |