| Tag | Content |
|---|---|
| Uniprot ID | G1K2L5 |
| Entrez ID | 30590 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001271820.1 |
| Ensembl protein ID | ENSDARP00000051548 |
| Ensembl nucleotide ID | ENSDARG00000035559 |
| Gene name | Cellular tumor antigen p53 |
| Gene symbol | tp53 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. |
| Sequence | MAQNDSQEFA ELWEKNLISI QPPGGGSCWD IINDEEYLPG SFDPNFFENV LEEQPQPSTL 60 PPTSTVPETS DYPGDHGFRL RFPQSGTAKS VTCTYSPDLN KLFCQLAKTC PVQMVVDVAP 120 PQGSVVRATA IYKKSEHVAE VVRRCPHHER TPDGDNLAPA GHLIRVEGNQ RANYREDNIT 180 LRHSVFVPYE APQLGAEWTT VLLNYMCNSS CMGGMNRRPI LTIITLETQE GQLLGRRSFE 240 VRVCACPGRD RKTEESNFKK DQETKTMAKT TTGTKRSLVK ESSSATLRPE GSKKAKGSSS 300 DEEIFTLQVR GRERYEILKK LNDSLELSDV VPASDAEKYR QKFMTKNKKE NRESSEPKQG 360 KKLMVKDEGR SDSD 374 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TP53 | 281542 | P67939 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TP53 | A0A452G0L9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TP53 | 7157 | P04637 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tp53 | 22059 | P02340 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TP53 | 455214 | H2QC53 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TP53 | G1SEU0 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tp53 | M0R497 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tp53 | 30590 | G1K2L5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0042802 | identical protein binding |
| GO:0046872 | metal ion binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0006915 | apoptotic process |
| GO:0007049 | cell cycle |
| GO:0051262 | protein tetramerization |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00348 | P53 |