Gene: Tp53

Basic information

Tag Content
Uniprot ID P02340; Q9QUP3;
Entrez ID 22059
Genbank protein ID CAA25625.1; AAA39881.1; CAA25420.1; AAB21108.2; BAA82344.1; AAA39882.1; AAH05448.1; AAA39883.1; CAA25323.1; BAA82343.1; BAA82340.1; BAA82339.1; AAD39535.1;
Genbank nucleotide ID NM_011640.3; XM_006533157.3; NM_001127233.1;
Ensembl protein ID ENSMUSP00000104298
Ensembl nucleotide ID ENSMUSG00000059552
Gene name Cellular tumor antigen p53
Gene symbol Tp53
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO,CLP
Developmental stage
Data sources Manually collected
Reference 25119037; 14744934;
Functional description Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Sequence
MTAMEESQSD ISLELPLSQE TFSGLWKLLP PEDILPSPHC MDDLLLPQDV EEFFEGPSEA 60
LRVSGAPAAQ DPVTETPGPV APAPATPWPL SSFVPSQKTY QGNYGFHLGF LQSGTAKSVM 120
CTYSPPLNKL FCQLAKTCPV QLWVSATPPA GSRVRAMAIY KKSQHMTEVV RRCPHHERCS 180
DGDGLAPPQH LIRVEGNLYP EYLEDRQTFR HSVVVPYEPP EAGSEYTTIH YKYMCNSSCM 240
GGMNRRPILT IITLEDSSGN LLGRDSFEVR VCACPGRDRR TEEENFRKKE VLCPELPPGS 300
AKRALPTCTS ASPPQKKKPL DGEYFTLKIR GRKRFEMFRE LNEALELKDA HATEESGDSR 360
AHSSYLKTKK GQSTSRHKKT MVKKVGPDSD

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database


loading...

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTP53281542P67939Bos taurusPredictionMore>>
1:1 orthologTP53A0A452G0L9Capra hircusPredictionMore>>
1:1 orthologTP537157P04637Homo sapiensPredictionMore>>
1:1 orthologTp5322059P02340CPO,CLPMus musculusPublicationMore>>
1:1 orthologTP53455214H2QC53Pan troglodytesPredictionMore>>
1:1 orthologTP53G1SEU0Oryctolagus cuniculusPredictionMore>>
1:1 orthologTp53M0R497Rattus norvegicusPredictionMore>>
1:1 orthologtp5330590G1K2L5Danio rerioPredictionMore>>

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingIDA
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA bindingISO
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA bindingIDA
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificISO
GO:0001046 core promoter sequence-specific DNA bindingISO
GO:0001085 RNA polymerase II transcription factor bindingISO
GO:0001094 TFIID-class transcription factor complex bindingISO
GO:0001102 RNA polymerase II activating transcription factor bindingISO
GO:0001221 transcription cofactor bindingISO
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificISO
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIGI
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIDA
GO:0002020 protease bindingISO
GO:0002039 p53 bindingISO
GO:0003677 DNA bindingISS
GO:0003677 DNA bindingISO
GO:0003682 chromatin bindingISO
GO:0003682 chromatin bindingIDA
GO:0003700 DNA-binding transcription factor activityISO
GO:0003700 DNA-binding transcription factor activityIDA
GO:0003730 mRNA 3'-UTR bindingISO
GO:0005507 copper ion bindingISS
GO:0005507 copper ion bindingISO
GO:0005515 protein bindingIPI
GO:0005524 ATP bindingISS
GO:0005524 ATP bindingISO
GO:0008022 protein C-terminus bindingISO
GO:0008134 transcription factor bindingISO
GO:0019899 enzyme bindingISO
GO:0019901 protein kinase bindingISO
GO:0019903 protein phosphatase bindingISO
GO:0030971 receptor tyrosine kinase bindingISO
GO:0031625 ubiquitin protein ligase bindingISO
GO:0031625 ubiquitin protein ligase bindingIPI
GO:0035033 histone deacetylase regulator activityIDA
GO:0035035 histone acetyltransferase bindingISO
GO:0042802 identical protein bindingISO
GO:0042803 protein homodimerization activityISO
GO:0042826 histone deacetylase bindingISO
GO:0043565 sequence-specific DNA bindingISO
GO:0043621 protein self-associationISO
GO:0044212 transcription regulatory region DNA bindingISO
GO:0046982 protein heterodimerization activityISO
GO:0047485 protein N-terminus bindingISO
GO:0051087 chaperone bindingISO
GO:0051721 protein phosphatase 2A bindingISO
GO:0097371 MDM2/MDM4 family protein bindingISO
GO:0097371 MDM2/MDM4 family protein bindingIPI
GO:0097718 disordered domain specific bindingISO
GO:1990841 promoter-specific chromatin bindingISS
GO:1990841 promoter-specific chromatin bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIISO
GO:0000122 negative regulation of transcription by RNA polymerase IIIGI
GO:0000122 negative regulation of transcription by RNA polymerase IIIMP
GO:0000122 negative regulation of transcription by RNA polymerase IIIDA
GO:0000733 DNA strand renaturationISS
GO:0000733 DNA strand renaturationISO
GO:0001701 in utero embryonic developmentIGI
GO:0001756 somitogenesisIGI
GO:0001836 release of cytochrome c from mitochondriaIGI
GO:0001836 release of cytochrome c from mitochondriaIDA
GO:0002244 hematopoietic progenitor cell differentiationISO
GO:0002309 T cell proliferation involved in immune responseIGI
GO:0002326 B cell lineage commitmentIMP
GO:0002360 T cell lineage commitmentIMP
GO:0002687 positive regulation of leukocyte migrationISO
GO:0002931 response to ischemiaIMP
GO:0006289 nucleotide-excision repairISS
GO:0006289 nucleotide-excision repairISO
GO:0006302 double-strand break repairIMP
GO:0006355 regulation of transcription, DNA-templatedISO
GO:0006355 regulation of transcription, DNA-templatedIDA
GO:0006357 regulation of transcription by RNA polymerase IIIDA
GO:0006606 protein import into nucleusIDA
GO:0006914 autophagyISO
GO:0006915 apoptotic processIDA
GO:0006915 apoptotic processIGI
GO:0006974 cellular response to DNA damage stimulusISO
GO:0006974 cellular response to DNA damage stimulusIMP
GO:0006974 cellular response to DNA damage stimulusIDA
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestISO
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIGI
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorISO
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDA
GO:0006979 response to oxidative stressIMP
GO:0006979 response to oxidative stressIGI
GO:0006983 ER overload responseISO
GO:0007050 cell cycle arrestISO
GO:0007179 transforming growth factor beta receptor signaling pathwayIGI
GO:0007265 Ras protein signal transductionIEA
GO:0007369 gastrulationIGI
GO:0007406 negative regulation of neuroblast proliferationIGI
GO:0007417 central nervous system developmentIGI
GO:0007507 heart developmentIGI
GO:0007569 cell agingISS
GO:0007569 cell agingISO
GO:0007569 cell agingIGI
GO:0007623 circadian rhythmIEP
GO:0008104 protein localizationISO
GO:0008156 negative regulation of DNA replicationIDA
GO:0008156 negative regulation of DNA replicationIMP
GO:0008285 negative regulation of cell population proliferationISO
GO:0008285 negative regulation of cell population proliferationIGI
GO:0008285 negative regulation of cell population proliferationIMP
GO:0008340 determination of adult lifespanIMP
GO:0009299 mRNA transcriptionISO
GO:0009303 rRNA transcriptionIGI
GO:0009411 response to UVIMP
GO:0009411 response to UVIDA
GO:0009651 response to salt stressIGI
GO:0009792 embryo development ending in birth or egg hatchingIGI
GO:0010038 response to metal ionIEA
GO:0010165 response to X-rayIDA
GO:0010165 response to X-rayIMP
GO:0010224 response to UV-BIEA
GO:0010332 response to gamma radiationISO
GO:0010332 response to gamma radiationIDA
GO:0010332 response to gamma radiationIMP
GO:0010628 positive regulation of gene expressionISO
GO:0010629 negative regulation of gene expressionIGI
GO:0010666 positive regulation of cardiac muscle cell apoptotic processIMP
GO:0016032 viral processISO
GO:0021549 cerebellum developmentIDA
GO:0030308 negative regulation of cell growthISS
GO:0030308 negative regulation of cell growthISO
GO:0030330 DNA damage response, signal transduction by p53 class mediatorISO
GO:0030330 DNA damage response, signal transduction by p53 class mediatorIDA
GO:0030330 DNA damage response, signal transduction by p53 class mediatorIGI
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0031000 response to caffeineIEA
GO:0031065 positive regulation of histone deacetylationIDA
GO:0031497 chromatin assemblyISO
GO:0031571 mitotic G1 DNA damage checkpointISO
GO:0031571 mitotic G1 DNA damage checkpointIMP
GO:0032461 positive regulation of protein oligomerizationISO
GO:0032526 response to retinoic acidIEA
GO:0033077 T cell differentiation in thymusIGI
GO:0033552 response to vitamin B3IEA
GO:0034103 regulation of tissue remodelingIMP
GO:0034605 cellular response to heatIEA
GO:0034613 cellular protein localizationISO
GO:0034614 cellular response to reactive oxygen speciesISO
GO:0034644 cellular response to UVISO
GO:0034644 cellular response to UVIGI
GO:0034644 cellular response to UVIDA
GO:0035264 multicellular organism growthIGI
GO:0035690 cellular response to drugIEA
GO:0035794 positive regulation of mitochondrial membrane permeabilityIGI
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stressISO
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stressIDA
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stressISS
GO:0042060 wound healingIEA
GO:0042127 regulation of cell population proliferationIGI
GO:0042127 regulation of cell population proliferationIMP
GO:0042149 cellular response to glucose starvationISO
GO:0042493 response to drugIDA
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorISO
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMP
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIGI
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDA
GO:0042981 regulation of apoptotic processISO
GO:0043065 positive regulation of apoptotic processISS
GO:0043065 positive regulation of apoptotic processISO
GO:0043065 positive regulation of apoptotic processIGI
GO:0043065 positive regulation of apoptotic processIMP
GO:0043066 negative regulation of apoptotic processISO
GO:0043066 negative regulation of apoptotic processIMP
GO:0043153 entrainment of circadian clock by photoperiodIMP
GO:0043200 response to amino acidIEA
GO:0043504 mitochondrial DNA repairIMP
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediatorIGI
GO:0043523 regulation of neuron apoptotic processIGI
GO:0043525 positive regulation of neuron apoptotic processIDA
GO:0043525 positive regulation of neuron apoptotic processIGI
GO:0043525 positive regulation of neuron apoptotic processIMP
GO:0045471 response to ethanolIEA
GO:0045787 positive regulation of cell cycleISO
GO:0045861 negative regulation of proteolysisIMP
GO:0045892 negative regulation of transcription, DNA-templatedISO
GO:0045892 negative regulation of transcription, DNA-templatedIMP
GO:0045892 negative regulation of transcription, DNA-templatedIDA
GO:0045893 positive regulation of transcription, DNA-templatedISO
GO:0045893 positive regulation of transcription, DNA-templatedIDA
GO:0045893 positive regulation of transcription, DNA-templatedIGI
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assemblyISO
GO:0045930 negative regulation of mitotic cell cycleIGI
GO:0045944 positive regulation of transcription by RNA polymerase IIISO
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0048147 negative regulation of fibroblast proliferationISO
GO:0048147 negative regulation of fibroblast proliferationIMP
GO:0048512 circadian behaviorIMP
GO:0048539 bone marrow developmentISO
GO:0048568 embryonic organ developmentIGI
GO:0048662 negative regulation of smooth muscle cell proliferationISO
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylationIMP
GO:0050821 protein stabilizationIGI
GO:0051123 RNA polymerase II preinitiation complex assemblyISO
GO:0051276 chromosome organizationIGI
GO:0051289 protein homotetramerizationISO
GO:0051402 neuron apoptotic processIGI
GO:0051402 neuron apoptotic processIMP
GO:0051453 regulation of intracellular pHISO
GO:0051726 regulation of cell cycleIMP
GO:0051726 regulation of cell cycleIGI
GO:0051974 negative regulation of telomerase activityISO
GO:0055093 response to hyperoxiaIEA
GO:0060218 hematopoietic stem cell differentiationISO
GO:0060333 interferon-gamma-mediated signaling pathwayIMP
GO:0060411 cardiac septum morphogenesisIGI
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaIMP
GO:0062100 positive regulation of programmed necrotic cell deathIMP
GO:0065003 protein-containing complex assemblyISO
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMP
GO:0070243 regulation of thymocyte apoptotic processIGI
GO:0070245 positive regulation of thymocyte apoptotic processIMP
GO:0070266 necroptotic processIGI
GO:0071158 positive regulation of cell cycle arrestISO
GO:0071479 cellular response to ionizing radiationISO
GO:0071479 cellular response to ionizing radiationIDA
GO:0071479 cellular response to ionizing radiationIGI
GO:0071480 cellular response to gamma radiationISO
GO:0071480 cellular response to gamma radiationIDA
GO:0071494 cellular response to UV-CIGI
GO:0071850 mitotic cell cycle arrestIDA
GO:0072331 signal transduction by p53 class mediatorISO
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediatorISO
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediatorIDA
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediatorIGI
GO:0072717 cellular response to actinomycin DISO
GO:0090200 positive regulation of release of cytochrome c from mitochondriaISO
GO:0090343 positive regulation of cell agingIMP
GO:0090399 replicative senescenceISO
GO:0090403 oxidative stress-induced premature senescenceISO
GO:0097252 oligodendrocyte apoptotic processISS
GO:0097252 oligodendrocyte apoptotic processISO
GO:1900119 positive regulation of execution phase of apoptosisISO
GO:1901525 negative regulation of mitophagyIMP
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic processIGI
GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIMP
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase IIISO
GO:1903205 regulation of hydrogen peroxide-induced cell deathISO
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNAIGI
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNAISO
GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvateIMP
GO:1905856 negative regulation of pentose-phosphate shuntISO
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxiaIMP
GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damageISO
GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damageISS
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressIMP
GO:2000269 regulation of fibroblast apoptotic processIGI
GO:2000279 negative regulation of DNA biosynthetic processISO
GO:2000378 negative regulation of reactive oxygen species metabolic processIMP
GO:2000379 positive regulation of reactive oxygen species metabolic processISO
GO:2000772 regulation of cellular senescenceIGI
GO:2001244 positive regulation of intrinsic apoptotic signaling pathwayISS
GO:2001244 positive regulation of intrinsic apoptotic signaling pathwayISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0000785 chromatinISO
GO:0000790 nuclear chromatinISO
GO:0000790 nuclear chromatinISS
GO:0005623 cellIEA
GO:0005634 nucleusISO
GO:0005634 nucleusISS
GO:0005634 nucleusIDA
GO:0005654 nucleoplasmISO
GO:0005657 replication forkIDA
GO:0005667 transcription factor complexISO
GO:0005730 nucleolusISS
GO:0005730 nucleolusISO
GO:0005737 cytoplasmISO
GO:0005737 cytoplasmISS
GO:0005737 cytoplasmIDA
GO:0005739 mitochondrionISS
GO:0005739 mitochondrionISO
GO:0005739 mitochondrionIDA
GO:0005759 mitochondrial matrixIDA
GO:0005783 endoplasmic reticulumIEA
GO:0005813 centrosomeISS
GO:0005829 cytosolISO
GO:0005829 cytosolIDA
GO:0016363 nuclear matrixISO
GO:0016605 PML bodyISO
GO:0031965 nuclear membraneISO
GO:0032991 protein-containing complexISO
GO:0035861 site of double-strand breakIDA
GO:0090575 RNA polymerase II transcription factor complexISO
GO:0005669 transcription factor TFIID complexISO
GO:0016604 nuclear bodyISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1640170 Cell CycleIEA
R-MMU-212436 Generic Transcription PathwayIEA
R-MMU-2262752 Cellular responses to stressIEA
R-MMU-2559580 Oxidative Stress Induced SenescenceIEA
R-MMU-2559583 Cellular SenescenceIEA
R-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)IEA
R-MMU-2559585 Oncogene Induced SenescenceIEA
R-MMU-2559586 DNA Damage/Telomere Stress Induced SenescenceIEA
R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1IEA
R-MMU-3700989 Transcriptional Regulation by TP53IEA
R-MMU-392499 Metabolism of proteinsIEA
R-MMU-453274 Mitotic G2-G2/M phasesIEA
R-MMU-5633007 Regulation of TP53 ActivityIEA
R-MMU-5688426 DeubiquitinationIEA
R-MMU-5689880 Ub-specific processing proteasesIEA
R-MMU-5689896 Ovarian tumor domain proteasesIEA
R-MMU-5693532 DNA Double-Strand Break RepairIEA
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksIEA
R-MMU-5693606 DNA Double Strand Break ResponseIEA
R-MMU-597592 Post-translational protein modificationIEA
R-MMU-6804754 Regulation of TP53 ExpressionIEA
R-MMU-6804756 Regulation of TP53 Activity through PhosphorylationIEA
R-MMU-6804757 Regulation of TP53 DegradationIEA
R-MMU-6804758 Regulation of TP53 Activity through AcetylationIEA
R-MMU-6804759 Regulation of TP53 Activity through Association with Co-factorsIEA
R-MMU-6804760 Regulation of TP53 Activity through MethylationIEA
R-MMU-6806003 Regulation of TP53 Expression and DegradationIEA
R-MMU-6811555 PI5P Regulates TP53 AcetylationIEA
R-MMU-69275 G2/M TransitionIEA
R-MMU-69278 Cell Cycle, MitoticIEA
R-MMU-69473 G2/M DNA damage checkpointIEA
R-MMU-69481 G2/M CheckpointsIEA
R-MMU-69541 Stabilization of p53IEA
R-MMU-69560 Transcriptional activation of p53 responsive genes IEA
R-MMU-69563 p53-Dependent G1 DNA Damage ResponseIEA
R-MMU-69580 p53-Dependent G1/S DNA damage checkpointIEA
R-MMU-69615 G1/S DNA Damage CheckpointsIEA
R-MMU-69620 Cell Cycle CheckpointsIEA
R-MMU-69895 Transcriptional activation of cell cycle inhibitor p21 IEA
R-MMU-73857 RNA Polymerase II TranscriptionIEA
R-MMU-73894 DNA RepairIEA
R-MMU-74160 Gene expression (Transcription)IEA
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpointIEA
R-MMU-8878159 Transcriptional regulation by RUNX3IEA
R-MMU-8941855 RUNX3 regulates CDKN1A transcriptionIEA
R-MMU-8953897 Cellular responses to external stimuliIEA

Drugs and compounds information

loading...

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0007 Acetylation
KW-0010 Activator
KW-0053 Apoptosis
KW-0090 Biological rhythms
KW-0131 Cell cycle
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0225 Disease mutation
KW-0238 DNA-binding
KW-0256 Endoplasmic reticulum
KW-1017 Isopeptide bond
KW-0479 Metal-binding
KW-0488 Methylation
KW-0496 Mitochondrion
KW-1210 Necrosis
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0043 Tumor suppressor
KW-0832 Ubl conjugation
KW-0862 Zinc

Interpro

InterPro ID InterPro Term
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR013872 p53_transactivation_domain
IPR002117 p53_tumour_suppressor

PROSITE

PROSITE ID PROSITE Term
PS00348 P53

Pfam

Pfam ID Pfam Term
PF00870 P53
PF08563 P53_TAD
PF07710 P53_tetramer