Gene: TP53

Basic information

Tag Content
Uniprot ID P67939; Q29628; Q3ZCF1;
Entrez ID 281542
Genbank protein ID ABG37911.1; AAI02441.1; BAA08629.1; CAA57348.1;
Genbank nucleotide ID NM_174201.2
Ensembl protein ID ENSBTAP00000001420
Ensembl nucleotide ID ENSBTAG00000001069
Gene name Cellular tumor antigen p53
Gene symbol TP53
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
Sequence
MEESQAELNV EPPLSQETFS DLWNLLPENN LLSSELSAPV DDLLPYTDVA TWLDECPNEA 60
PQMPEPSAPA APPPATPAPA TSWPLSSFVP SQKTYPGNYG FRLGFLQSGT AKSVTCTYSP 120
SLNKLFCQLA KTCPVQLWVD SPPPPGTRVR AMAIYKKLEH MTEVVRRCPH HERSSDYSDG 180
LAPPQHLIRV EGNLRAEYLD DRNTFRHSVV VPYESPEIDS ECTTIHYNFM CNSSCMGGMN 240
RRPILTIITL EDSCGNLLGR NSFEVRVCAC PGRDRRTEEE NLRKKGQSCP EPPPRSTKRA 300
LPTNTSSSPQ PKKKPLDGEY FTLQIRGFKR YEMFRELNDA LELKDALDGR EPGESRAHSS 360
HLKSKKRPSP SCHKKPMLKR EGPDSD 386

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTP53281542P67939Bos taurusPredictionMore>>
1:1 orthologTP53A0A452G0L9Capra hircusPredictionMore>>
1:1 orthologTP537157P04637Homo sapiensPredictionMore>>
1:1 orthologTp5322059P02340CPO,CLPMus musculusPublicationMore>>
1:1 orthologTP53455214H2QC53Pan troglodytesPredictionMore>>
1:1 orthologTP53G1SEU0Oryctolagus cuniculusPredictionMore>>
1:1 orthologTp53M0R497Rattus norvegicusPredictionMore>>
1:1 orthologtp5330590G1K2L5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005813 centrosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005783 endoplasmic reticulum
GO:0005759 mitochondrial matrix
GO:0005739 mitochondrion
GO:0000790 nuclear chromatin
GO:0016363 nuclear matrix
GO:0031965 nuclear membrane
GO:0005730 nucleolus
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016605 PML body
GO:0005657 replication fork
GO:0035861 site of double-strand break
GO:0005669 transcription factor TFIID complex
GO:0005524 ATP binding
GO:0051087 chaperone binding
GO:0005507 copper ion binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0097718 disordered domain specific binding
GO:0003677 DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0035033 histone deacetylase regulator activity
GO:0042802 identical protein binding
GO:0097371 MDM2/MDM4 family protein binding
GO:0003730 mRNA 3'-UTR binding
GO:0002039 p53 binding
GO:1990841 promoter-specific chromatin binding
GO:0002020 protease binding
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0051721 protein phosphatase 2A binding
GO:0043621 protein self-association
GO:0030971 receptor tyrosine kinase binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001094 TFIID-class transcription factor complex binding
GO:0031625 ubiquitin protein ligase binding
GO:0006914 autophagy
GO:0002326 B cell lineage commitment
GO:0048539 bone marrow development
GO:0060411 cardiac septum morphogenesis
GO:0007569 cell aging
GO:0072717 cellular response to actinomycin D
GO:0006974 cellular response to DNA damage stimulus
GO:0035690 cellular response to drug
GO:0071480 cellular response to gamma radiation
GO:0042149 cellular response to glucose starvation
GO:0071494 cellular response to UV-C
GO:0021549 cerebellum development
GO:0031497 chromatin assembly
GO:0048512 circadian behavior
GO:0008340 determination of adult lifespan
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0000733 DNA strand renaturation
GO:0006302 double-strand break repair
GO:0048568 embryonic organ development
GO:0043153 entrainment of circadian clock by photoperiod
GO:0006983 ER overload response
GO:0007369 gastrulation
GO:0060218 hematopoietic stem cell differentiation
GO:0001701 in utero embryonic development
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
GO:0043504 mitochondrial DNA repair
GO:0071850 mitotic cell cycle arrest
GO:0009299 mRNA transcription
GO:0035264 multicellular organism growth
GO:0070266 necroptotic process
GO:0043066 negative regulation of apoptotic process
GO:0030308 negative regulation of cell growth
GO:0008156 negative regulation of DNA replication
GO:0048147 negative regulation of fibroblast proliferation
GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate
GO:1901525 negative regulation of mitophagy
GO:0007406 negative regulation of neuroblast proliferation
GO:1905856 negative regulation of pentose-phosphate shunt
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0045861 negative regulation of proteolysis
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:0051974 negative regulation of telomerase activity
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045892 negative regulation of transcription, DNA-templated
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051402 neuron apoptotic process
GO:0006289 nucleotide-excision repair
GO:0097252 oligodendrocyte apoptotic process
GO:0090403 oxidative stress-induced premature senescence
GO:0043065 positive regulation of apoptotic process
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0090343 positive regulation of cell aging
GO:1900119 positive regulation of execution phase of apoptosis
GO:0031065 positive regulation of histone deacetylation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0043525 positive regulation of neuron apoptotic process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:0062100 positive regulation of programmed necrotic cell death
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006606 protein import into nucleus
GO:0050821 protein stabilization
GO:0051262 protein tetramerization
GO:0007265 Ras protein signal transduction
GO:2000772 regulation of cellular senescence
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:2000269 regulation of fibroblast apoptotic process
GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0034103 regulation of tissue remodeling
GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damage
GO:0001836 release of cytochrome c from mitochondria
GO:0090399 replicative senescence
GO:0002931 response to ischemia
GO:0009651 response to salt stress
GO:0010165 response to X-ray
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0009303 rRNA transcription
GO:0001756 somitogenesis
GO:0033077 T cell differentiation in thymus
GO:0002360 T cell lineage commitment
GO:0002309 T cell proliferation involved in immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0016032 viral process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0010 Activator
KW-0053 Apoptosis
KW-0090 Biological rhythms
KW-0131 Cell cycle
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0238 DNA-binding
KW-0256 Endoplasmic reticulum
KW-1017 Isopeptide bond
KW-0479 Metal-binding
KW-0488 Methylation
KW-0496 Mitochondrion
KW-1210 Necrosis
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0043 Tumor suppressor
KW-0832 Ubl conjugation
KW-0862 Zinc

Interpro

InterPro ID InterPro Term
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR013872 p53_transactivation_domain
IPR002117 p53_tumour_suppressor

PROSITE

PROSITE ID PROSITE Term
PS00348 P53

Pfam

Pfam ID Pfam Term
PF00870 P53
PF08563 P53_TAD
PF07710 P53_tetramer