Gene: ZEB1

Basic information

Tag Content
Uniprot ID A0A5F4BPF2
Entrez ID 477966
Genbank protein ID
Genbank nucleotide ID XM_003638879.3
Ensembl protein ID ENSCAFP00000043378
Ensembl nucleotide ID ENSCAFG00000004023
Gene name Zinc finger E-box binding homeobox 1
Gene symbol ZEB1
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESITDA ADCEGGVPED 60
DLPTDQTVLP GSSEREGNAK SCWEDNAGKE GQEILGPEAQ ADEARCAVKD DECDSDAENE 120
QNHDPNVEEF LQQQDTAVIY PEAPEEDQRQ GTPEASGHDD SGTPDAFSQL LTCPYCDRGY 180
KRFTSLKEHI KYRHEKNEDN FSCSLCSYTF AYRTQLERHM TSHKSGRDQR HVTQSGGNRK 240
FKCTECGKAF KYKHHLKEHL RIHSGEKPYE CPNCKKRFSH SGSYSSHISS KKCISLMPVN 300
GRPRTGLKTP QCSSPSLSAS PGSPTRPQIR QKIENKPLQE QLSINQIKTE PVDYEFKPIV 360
VASGINCSTP LQNGVFSGGG PLQATSSPQG VVQAVVLPTV GLVSPISINL SDIQNVLKVA 420
VDGNVIRQVL ENNQASLASK EQETISASSI QQGGHSVISA ISLPLVDQDG TTKIIINYSL 480
EQPSQLQVVP QNLKTENPVP TNSCKSEKLP EDLTVKSEKD KNFEGGVNDS TCLLCDECPG 540
DINALPELKH YDLKQPAQPP PLPAPEAEKP ESSVSSGGDG NLSPSQPPLK NLLSLLKAYY 600
ALNAQPSAEE LSKIADSVNL PLDVVKKWFE KMQAGQISVQ SSEPSSPETG KVNIPTKNDE 660
QPQSTNANEP LDSTVNLQSP LKMTNSPVLP AGSTTNGSRS SPSSPSPLNL SSSRNTQGYL 720
YTAEGAQEEP QVEPLDLSLP KQQGELLERS TITSVYQNSV YSVQEEPLNL SCAKKEPQKD 780
SCVTDSEPVV NVIPPSANPI NIAIPTVTAQ LPTIVAIADQ NSVPCLRALA ANKQTILIPQ 840
VAYTYSTTVS PAVQEPPLKV IQPNGNQEER QDTSSEGVSN VEDQNDSDST PPKKKMRKTE 900
NGMYACDLCD KIFQKSSSLL RHKYEHTGKR PHECGICKKA FKHKHHLIEH MRLHSGEKPY 960
QCDKCGKRFS HSGSYSQHMN HRYSYCKREA EERDSTEQEE AGPEVLASEH VGARGSPSQA 1020
DSDERESLMR EEDEDSEKEE EEEEDKEMEE LQEEKECEKP QGEEEEEEEE DEMEEEEGEE 1080
AENEGEEAKT EGLMKEDEVV NQESNLEQKV SKNSEQVSEE KTNEA 1125

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologZEB1477966A0A5F4BPF2Canis lupus familiarisPredictionMore>>
1:1 orthologZEB1106502734A0A452EVD0Capra hircusPredictionMore>>
1:1 orthologZEB16935P37275Homo sapiensPredictionMore>>
1:1 orthologZeb121417Q64318CPO,CLPE11.5, E12.5, E13.5, E14.5Mus musculusPublicationMore>>
1:1 orthologZEB1450387K7CJ20Pan troglodytesPredictionMore>>
1:1 orthologZeb1F8WG35Rattus norvegicusPredictionMore>>
1:1 orthologzeb1bF1QPM7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0003677 DNA binding

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR008598 Di19_Zn_binding_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00096 zf-C2H2
PF05605 zf-Di19