| Tag | Content |
|---|---|
| Uniprot ID | F8WG35 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000024336 |
| Ensembl nucleotide ID | ENSRNOG00000017863 |
| Gene name | Zinc finger E-box-binding homeobox 1 |
| Gene symbol | Zeb1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | VTNYNTVVEA NSDSDDEDKL HIVEEESVTD AADCEGGVPD DELPTDQTVL PGGSDRAGSA 60 KNCWQDDVKD DECDSDAENE QNHDPNVEEF LQQQDTAVIY PEAPEEDQRQ GTPEASGHDD 120 NGTPDAFSQL LTCPYCDRGY KRFTSLKEHI KYRHEKNEDN FSCSLCSYTF AYRTQLERHM 180 TSHKSGREQR HVTQSGGNRK FKCTECGKAF KYKHHLKEHL RIHSGEKPYE CPNCKKRFSH 240 SGSYSSHISS KKCISLMPVN GRPRSGLKTS QCSSPSLSTS PGSPTRPQIR QKIENKPLQE 300 PLSVNQIKTE PVDYEFKPIV VASGINCSTP LQNGVFSGGG QLQATSSPQG VVQAVVLPTV 360 GLVSPISINL SDIQNVLKVA VDGNIIRQVL ENNQASLASK EQEAVSASSI QQGGHSVISA 420 ISLPLVDQDG TTKIIINYSL EQPGQLQVVP QNLKKENPAP PKSCKSEKSP EDLTVKSEKD 480 KSFDGAADES TCLLCEDCPG DLNALPELKH YDPEHPAQPP PPAPATEKPE SSASSAGNGD 540 LSPSQPPLKN LLSLLKAYYA LNAQPSTEEL TKIADSVNLP LDVVKKWFEK MQAGQIPGQS 600 LEPPSPGPGS GNIPKTEEQP QPVDGNEPQE DSTRGQSPLK MTSSPVLPVG SAINGSRSCT 660 SSPSPLNLSS ARNPQGYSCV SEGTQEEPQV EPLDLSLPKQ QGELLERSTV SSVYQNSVYS 720 VQEEPLNLSC AKKEPQKDSC VTDSEPVVNV VPPSANPINI AIPTVTAQLP TIVAIADQNS 780 VPCLRALAAN KQTILIPQVA YTYSATVSPA MQEPPVKVIQ PNGNQDERQD TSSEGVSVED 840 QNDSDCTPPK KKTRKAENGM YACDLCDKIF QKSSSLLRHK YEHTGKRPHE CGICRKAFKH 900 KHHLIEHMRL HSGEKPYQCD KCGKRFSHSG SYSQHMNHRY SYCKRGAEDR DAMEQEDTGP 960 EALPEVLPTE LVGARASPSQ ADSDERESLT REEDEDSEKE EEEEDKEMEE LQEDKECENP 1020 QEEEEEEEEE EEEEEEEEEE EAEEAEHEAA AAKTGGAVEE EAAQQAGSFQ QKASGSESKR 1080 LSEEKTNEA 1089 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ZEB1 | 477966 | A0A5F4BPF2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ZEB1 | 106502734 | A0A452EVD0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ZEB1 | 6935 | P37275 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Zeb1 | 21417 | Q64318 | CPO,CLP | E11.5, E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | ZEB1 | 450387 | K7CJ20 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Zeb1 | F8WG35 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | zeb1b | F1QPM7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0005654 | nucleoplasm |
| GO:0003682 | chromatin binding |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0070888 | E-box binding |
| GO:0051216 | cartilage development |
| GO:0071230 | cellular response to amino acid stimulus |
| GO:0007417 | central nervous system development |
| GO:0090103 | cochlea morphogenesis |
| GO:0048596 | embryonic camera-type eye morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045602 | negative regulation of endothelial cell differentiation |
| GO:0007389 | pattern specification process |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0010464 | regulation of mesenchymal cell proliferation |
| GO:0051150 | regulation of smooth muscle cell differentiation |
| GO:0033081 | regulation of T cell differentiation in thymus |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| GO:0048752 | semicircular canal morphogenesis |