Gene: Zeb1

Basic information

Tag Content
Uniprot ID Q64318; A4QPD2; Q62519;
Entrez ID 21417
Genbank protein ID AAB08442.1; AAI39770.1; AAA67564.1; BAA11177.1;
Genbank nucleotide ID NM_011546.3
Ensembl protein ID ENSMUSP00000025081
Ensembl nucleotide ID ENSMUSG00000024238
Gene name Zinc finger E-box-binding homeobox 1
Gene symbol Zeb1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO,CLP
Developmental stage E11.5, E12.5, E13.5, E14.5
Data sources Manually collected
Reference 13539273; 10669096; 9389660; 21980308; 16598713; 3183090; 11681996;
Functional description Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Sequence
MADGPRCKRR KQANPRRNNV TNYNTVVEAN SDSDDEDKLH IVEEESITDA ADCEGGMPDD 60
ELPADQTVLP GGSDRGGGAK NCWQDNVKDN ECDSDAENEQ NHDPNVEEFL QQQDTAVIYP 120
EAPEEDQRQG TPEASSHDEN GTPDAFSQLL TCPYCDRGYK RFTSLKEHIK YRHEKNEDNF 180
SCSLCSYTFA YRTQLERHMT SHKSGREQRH VTQSGGNRKF KCTECGKAFK YKHHLKEHLR 240
IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCISLMPVNG RPRSGLKTSQ CSSPSLSTSP 300
GSPTRPQIRQ KIENKPLQEP LSVNQIKTEP VDYEFKPIVV ASGINCSTPL QNGVFSSGGQ 360
LQATSSPQGV VQAVVLPTVG LVSPISINLS DIQNVLKVAV DGNVIRQVLE TNQASLASKE 420
QEAVSASPIQ QGGHSVISAI SLPLVDQDGT TKIIINYSLE QPSQLQVVPQ NLKKEIPAPT 480
NSCKSEKLPE DLTVKSETDK SFEGARDDST CLLCEDCPGD LNALPELKHY DPECPAQPPP 540
PAPATEKPES SASSAGNGDL SPSQPPLKNL LSLLKAYYAL NAQPSTEELS KIADSVNLPL 600
DGVKKWFEKM QAGQIPGQSP DPPSPGTGSV NIPTKTDEQP QPADGNEPQE DSTRGQSPVK 660
IRSSPVLPVG SAMNGSRSCT SSPSPLNLCS ARNPQGYSCV AEGAQEEPQV EPLDLSLPKQ 720
QGELLERSTV SSVYQNSVYS VQEEPLNLSC AKKEPQKDSC VTDSEPVVNV VPPSANPINI 780
AIPTVTAQLP TIVAIADQNS VPCLRALAAN KQTILIPQVA YTYSATVSPA VQEPPVKVIQ 840
PNGNQDERQD TSSEGVSTVE DQNDSDSTPP KKKTRKTENG MYACDLCDKI FQKSSSLLRH 900
KYEHTGKRPH ECGICRKAFK HKHHLIEHMR LHSGEKPYQC DKCGKRFSHS GSYSQHMNHR 960
YSYCKRGAED RDAMEQEDAG PEVLPEVLAT EHVGARASPS QADSDERESL TREEDEDSEK 1020
EEEEEDKEME ELQEGKECEN PQGEEEEEEE EEEEEEEEEE EEVEADEAEH EAAAKTDGTV 1080
EVGAAQQAGS LEQKASESEM ESESESEQLS EEKTNEA 1117

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologZEB1477966A0A5F4BPF2Canis lupus familiarisPredictionMore>>
1:1 orthologZEB1106502734A0A452EVD0Capra hircusPredictionMore>>
1:1 orthologZEB16935P37275Homo sapiensPredictionMore>>
1:1 orthologZeb121417Q64318CPO,CLPE11.5, E12.5, E13.5, E14.5Mus musculusPublicationMore>>
1:1 orthologZEB1450387K7CJ20Pan troglodytesPredictionMore>>
1:1 orthologZeb1F8WG35Rattus norvegicusPredictionMore>>
1:1 orthologzeb1bF1QPM7Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specificISO
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specificIDA
GO:0003682 chromatin bindingISO
GO:0003682 chromatin bindingIDA
GO:0003690 double-stranded DNA bindingISO
GO:0005515 protein bindingIPI
GO:0043565 sequence-specific DNA bindingISO
GO:0046872 metal ion bindingIEA
GO:0070888 E-box bindingIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIISO
GO:0000122 negative regulation of transcription by RNA polymerase IIIMP
GO:0007389 pattern specification processIMP
GO:0007417 central nervous system developmentIGI
GO:0008285 negative regulation of cell population proliferationIMP
GO:0010464 regulation of mesenchymal cell proliferationIMP
GO:0017015 regulation of transforming growth factor beta receptor signaling pathwayIGI
GO:0030857 negative regulation of epithelial cell differentiationIMP
GO:0033081 regulation of T cell differentiation in thymusIMP
GO:0045602 negative regulation of endothelial cell differentiationISO
GO:0045666 positive regulation of neuron differentiationIDA
GO:0045892 negative regulation of transcription, DNA-templatedISS
GO:0045892 negative regulation of transcription, DNA-templatedISO
GO:0045892 negative regulation of transcription, DNA-templatedIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIISO
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0048513 animal organ developmentIMP
GO:0048596 embryonic camera-type eye morphogenesisIMP
GO:0048598 embryonic morphogenesisIGI
GO:0048704 embryonic skeletal system morphogenesisIMP
GO:0048752 semicircular canal morphogenesisIMP
GO:0051150 regulation of smooth muscle cell differentiationIMP
GO:0051216 cartilage developmentIMP
GO:0071230 cellular response to amino acid stimulusIDA
GO:0090103 cochlea morphogenesisIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISO
GO:0005634 nucleusIDA
GO:0005654 nucleoplasmISO
GO:0005829 cytosolISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0010 Activator
KW-0221 Differentiation
KW-0238 DNA-binding
KW-0371 Homeobox
KW-1017 Isopeptide bond
KW-0479 Metal-binding
KW-0524 Neurogenesis
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0832 Ubl conjugation
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR008598 Di19_Zn_binding_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00096 zf-C2H2
PF05605 zf-Di19

Protein-protein interaction

Protein-miRNA interaction