Gene: ZEB1

Basic information

Tag Content
Uniprot ID K7CJ20; A0A2J8MN86;
Entrez ID 450387
Genbank protein ID JAA32473.1; JAA44441.1; JAA12577.1;
Genbank nucleotide ID XM_016962902.1
Ensembl protein ID ENSPTRP00000089955
Ensembl nucleotide ID ENSPTRG00000002404
Gene name Zinc finger E-box binding homeobox 1
Gene symbol ZEB1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA ADCEGVPEDD 60
LPTDQTVLPG RSSEREGNAK NCWEDDTGKE GQEILGPEAQ ADEAGCTVKD DECESDAENE 120
QNHDPNVEEF LQQQDTAVIF PEAPEEDQRQ GTPEASGHDE NGTPDAFSQL LTCPYCDRGY 180
KRFTSLKEHI KYRHEKNEDN FSCSLCSYTF AYRTQLERHM TSHKSGRDQR HVTQSGCNRK 240
FKCTECGKAF KYKHHLKEHL RIHSGEKPYE CPNCKKRFSH SGSYSSHISS KKCISLIPVN 300
GRPRTGLKTS QCSSPSLSAS PGSPTRPQIR QKIENKPLQE QLSVNQIKTE PVDYEFKPIV 360
VASGINCSTP LQNGVFTGGG PLQATSSPQG MVQAVVLPTV GLVSPISINL SDIQNVLKVA 420
VDGNVIRQVL ENNQANLASK EQETINASPI QQGGHSVISA ISLPLVDQDG TTKIIINYSL 480
EQPSQLQVVP QNLKKENPVA TNSCKSEKLP EDLTVKSEKD KSFEGGVNDS TCLLCDDCPG 540
DINALPELKH YDLKQPTQPP PLPAAEAEKP ESSVSSATGD GNLSPSQPPL KNLLSLLKAY 600
YALNAQPSAE ELSKIADSVN LPLDVVKKWF EKMQAGQISV QSSEPSSPEP GKVNIPAKNN 660
DQPQSANANE PQDSTVNLQS PLKMTNSPVL PVGSTTNGSR SSTPSPSPLN LSSSRNTQGY 720
LYTAEGAQEE PQVEPLDLSL PKQQGELLER STITSVYQNS VYSVQEEPLN LSCAKKEPQK 780
DSCVTDSEPV VNVIPPSANP INIAIPTVTA QLPTIVAIAD QNSVPCLRAL AANKQTILIP 840
QVAYTYSTTV SPAVQEPPLK VIQPNGNQDE RQDTSSEGVS NVEDQNDSDS TPPKKKMRKT 900
ENGMYACDLC DKIFQKSSSL LRHKYEHTGK RPHECGICKK AFKHKHHLIE HMRLHSGEKP 960
YQCDKCGKRF SHSGSYSQHM NHRYSYCKRE AEERDSTEQE EAGPEILSNE HVGARASPSQ 1020
GDSDERESLT REEDEDSEKE EEEEDKEMEE LQEEKECEKP QGDEEEEEEE EEEVEEEEVE 1080
EAENEGEEAK TEGLMKDDRA ESQASSLGQK VGESSEQVSE EKTNEA 1126

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologZEB1477966A0A5F4BPF2Canis lupus familiarisPredictionMore>>
1:1 orthologZEB1106502734A0A452EVD0Capra hircusPredictionMore>>
1:1 orthologZEB16935P37275Homo sapiensPredictionMore>>
1:1 orthologZeb121417Q64318CPO,CLPE11.5, E12.5, E13.5, E14.5Mus musculusPublicationMore>>
1:1 orthologZEB1450387K7CJ20Pan troglodytesPredictionMore>>
1:1 orthologZeb1F8WG35Rattus norvegicusPredictionMore>>
1:1 orthologzeb1bF1QPM7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0003677 DNA binding

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR008598 Di19_Zn_binding_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00096 zf-C2H2
PF05605 zf-Di19