| Tag | Content |
|---|---|
| Uniprot ID | A2A8L5; Q6PG86; Q9EQ17; |
| Entrez ID | 19268 |
| Genbank protein ID | AAH57166.1; AAG40194.1; |
| Genbank nucleotide ID | NM_011213.2 |
| Ensembl protein ID | ENSMUSP00000039368 |
| Ensembl nucleotide ID | ENSMUSG00000033295 |
| Gene name | Receptor-type tyrosine-protein phosphatase F |
| Gene symbol | Ptprf |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19273906; 23863482; |
| Functional description | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). |
| Sequence | MAPEPAPGRR MVPLVPALVM LGLMAGAHGD SKPVFVKVPE DQTGLSGGVA SFVCQATGEP 60 KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 120 KLSVLEEDQL PSGFPTIDMG PQLKVVEKGR TATMLCAAGG NPDPEISWFK DFLPVDPAAS 180 NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 240 QEVMPGGSVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV MRSANYTCVA 300 ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNTEPVSFY GIQYRAAGTD 360 GPFQEVDGVA STRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 420 QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP 480 GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA NAESDTRIQL SWLLPPQERI 540 VKYELVYWAA EDEGQQHKVT FDPTSSYTLE DLKPDTLYHF QLAARSDLGV GVFTPTVEAR 600 TAQSTPSAPP QKVTCVSTGS TTVRVSWVPP PADSRNGIIT QYSVAYEAVD GEDRKRHVVD 660 GISREHSSWD LLGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 720 NSTAVHVSWK LPVPNKQHGQ IRGYQVTYVR LENGEPRGQP IIQDVMLAEA QETTISGLTP 780 ETTYSITVAA YTTKGDGARS KPKVVTTTGA VPGRPTMMVS TTAMHTALLQ WHPPKELPGE 840 LLGYRLQYRR ADEARPNTID FGKDDQHFTV TGLHKGATYV FRLAAKNRAG PGEEFEKEIT 900 TPEDVPSGFP QNLRVTGLTT STTELTWDPP VLAERNGHIT NYTVVYRDIN SQLELQNVTN 960 DTHLTLLGLK PDTTYDIKVR AHTSKGAGPL SPSIQSRTMP VEQVFAKNFR VAAAMKTSVL 1020 LSWEVPDSYK SAVPFKILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGSSAGGLQH 1080 LVSIRTAPDL LPQKPLPASA FIEDGRFSLS MPQVQDPSLV RWFYIVVVPI DRVGGNLLAP 1140 RWNTPEELEL DELLEAIEQG EEKQRRRRRQ AERLKPYVAA QVDVLPDTFT LGDKKSYRGF 1200 YNRPLSPDLS YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP EMLWVTGPVL 1260 AVILIILIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH 1320 PPIPITDLAD NIERLKANDG LKFSQEYESI DPGQQFTWEN SNSEVNKPKN RYANVIAYDH 1380 SRVLLTSIDG VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM 1440 TRLEEKSRVK CDQYWPVRGT ETYGLIQVTL VDTVELATYT MRTFALHKSG SSEKRELRQF 1500 QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK 1560 HEKTVDIYGH VTCMRSQRNY MVQTEDQYVF IHEALLEAAM CGHTEVLARN LYAHIQKLGQ 1620 VPPGESVTAM ELEFKLLANS KAHTSRFVSA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV 1680 EGSDYINASF LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC 1740 HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 1800 KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ 1860 TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT 1898 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPRF | 512072 | A7MBJ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PTPRF | A0A452EN77 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PTPRF | 5792 | P10586 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptprf | 19268 | A2A8L5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PTPRF | 456828 | K7D8P0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A480JVC3 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Ptprf | A0A0G2JT62 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IDA |
| GO:0004721 | phosphoprotein phosphatase activity | ISO |
| GO:0004725 | protein tyrosine phosphatase activity | ISS |
| GO:0004725 | protein tyrosine phosphatase activity | ISO |
| GO:0004725 | protein tyrosine phosphatase activity | IBA |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | ISO |
| GO:0005158 | insulin receptor binding | ISO |
| GO:0008201 | heparin binding | IEA |
| GO:0030971 | receptor tyrosine kinase binding | ISO |
| GO:0035373 | chondroitin sulfate proteoglycan binding | IPI |
| GO:0042301 | phosphate ion binding | ISO |
| GO:0044877 | protein-containing complex binding | IDA |
| GO:0050839 | cell adhesion molecule binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001960 | negative regulation of cytokine-mediated signaling pathway | ISO |
| GO:0006470 | protein dephosphorylation | ISO |
| GO:0006470 | protein dephosphorylation | IBA |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | ISO |
| GO:0007399 | nervous system development | ISO |
| GO:0008285 | negative regulation of cell population proliferation | ISO |
| GO:0010975 | regulation of neuron projection development | IMP |
| GO:0016477 | cell migration | ISS |
| GO:0016477 | cell migration | ISO |
| GO:0031102 | neuron projection regeneration | IMP |
| GO:0031345 | negative regulation of cell projection organization | ISO |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | ISS |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | ISO |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IBA |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | ISO |
| GO:0043065 | positive regulation of apoptotic process | ISO |
| GO:0043525 | positive regulation of neuron apoptotic process | ISO |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | ISO |
| GO:0048679 | regulation of axon regeneration | IMP |
| GO:0050775 | positive regulation of dendrite morphogenesis | ISO |
| GO:0050803 | regulation of synapse structure or activity | ISO |
| GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway | ISO |
| GO:0099175 | regulation of postsynapse organization | ISO |
| GO:0099560 | synaptic membrane adhesion | ISO |
| GO:0099560 | synaptic membrane adhesion | IBA |
| GO:1900121 | negative regulation of receptor binding | ISS |
| GO:1900121 | negative regulation of receptor binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005768 | endosome | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0016020 | membrane | ISO |
| GO:0030426 | growth cone | ISO |
| GO:0043005 | neuron projection | ISO |
| GO:0043005 | neuron projection | IDA |
| GO:0043025 | neuronal cell body | ISO |
| GO:0043025 | neuronal cell body | IDA |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0060076 | excitatory synapse | ISO |
| GO:0099061 | integral component of postsynaptic density membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-112316 | Neuronal System | IEA |
| R-MMU-388844 | Receptor-type tyrosine-protein phosphatases | IEA |
| R-MMU-6794362 | Protein-protein interactions at synapses | IEA |
| R-MMU-8849932 | Synaptic adhesion-like molecules | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0130 | Cell adhesion |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0358 | Heparin-binding |
| KW-0378 | Hydrolase |
| KW-0393 | Immunoglobulin domain |
| KW-0472 | Membrane |
| KW-0597 | Phosphoprotein |
| KW-0904 | Protein phosphatase |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| InterPro ID | InterPro Term |
|---|---|
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR029021 | Prot-tyrosine_phosphatase-like |
| IPR000242 | PTPase_domain |
| IPR016130 | Tyr_Pase_AS |
| IPR003595 | Tyr_Pase_cat |
| IPR000387 | TYR_PHOSPHATASE_dom |