| Tag | Content |
|---|---|
| Uniprot ID | A7MBJ4 |
| Entrez ID | 512072 |
| Genbank protein ID | AAI51593.1 |
| Genbank nucleotide ID | NM_001101079.1 |
| Ensembl protein ID | ENSBTAP00000059113 |
| Ensembl nucleotide ID | ENSBTAG00000000253 |
| Gene name | Receptor-type tyrosine-protein phosphatase F |
| Gene symbol | PTPRF |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). |
| Sequence | MTPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFVKVPE DQTGLSGGVA SFVCQATGEP 60 KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 120 KLSVLEEEQL PLGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPAAS 180 NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 240 QEVMPGGSVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA 300 ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVSYY GIQYRPAGAE 360 GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 420 QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP 480 GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA EVDSDTRIQL SWLLPPQERI 540 VKYELVYWAA EDEGQQHKVT FDPTSSYTVE DLKPDTLYRF QLAARSELGV GVFTPTIEAR 600 TAQSTPSAPP QKVTCVSVGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD GEDRGRHVVD 660 GIGREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 720 NSTAVRVSWK LPVPSKQHGQ IRGYQVTYVR LENGEPRGAP IIQDVMLAEA QETTISGLTP 780 ETTYSITVAA YTTKGDGARS KPKIVTTTGA VPGRPTMMVS TTAMNTALLQ WHPPKELPGE 840 LLGYRLQYRR ADEARPSTID FGKDDQHFTV TGLHKGATYI FRLTAKNRAG LGEEFEKEIT 900 TPEDVPSGFP QNLRVIGLTT STTELIWDPP VLAERNGRIT NYTVVYRDIN SQQELQNVTA 960 DTHLTLSGLK PDTTYDIKVR ARTSKGAGPL SPSIQSRTMP VEQVFAKNFR VEAAMKTSVL 1020 LSWEVPDSYK SAVPFRILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGSSAGGLQH 1080 LVSIRTAPDL LPHKPLPASA YIEDGRFTLT MPRVQEPALV RWFYIMVVPI DRMGGSMLAP 1140 QWSTPEELEL DELLEAIEQG GGERLRRRRQ TERLKPYVAA QVDVLPETFT LGDKKNYQGF 1200 YNRPLSPDLS YQCFVLASLK EPVDQKRYAC SPYSDEIVVQ VTPAQQQEEP ELLWVTGPVL 1260 AVILIVLIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH 1320 PPIPITDLAD NIERLKANDG LKFSQEYESI DPGQQFTWEN SNLEVNKPKN RYANVIAYDH 1380 SRVILTSIDG VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM 1440 TRLEEKSRVK CDQYWPARGT ETYGLIQVTL LDTVELATYT VRTFALYKSG SSEKRELRQF 1500 QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK 1560 HEKTVDIYGH VTCMRAQRNY MVQTEDQYVF IHEALLEAAM CGHTEVPARN LYAHIQKLGQ 1620 VPPGESVTAM ELEFKLLANS KAHTSRFISA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV 1680 EGSDYINASF LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT RLREMGREKC 1740 HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 1800 KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ 1860 TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT 1898 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPRF | 512072 | A7MBJ4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PTPRF | A0A452EN77 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PTPRF | 5792 | P10586 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptprf | 19268 | A2A8L5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PTPRF | 456828 | K7D8P0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A480JVC3 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Ptprf | A0A0G2JT62 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0008201 | heparin binding |
| GO:0004725 | protein tyrosine phosphatase activity |
| GO:0016477 | cell migration |
| GO:1900121 | negative regulation of receptor binding |
| GO:0035335 | peptidyl-tyrosine dephosphorylation |
| GO:0006470 | protein dephosphorylation |
| GO:0099560 | synaptic membrane adhesion |
| Keyword ID | Keyword Term |
|---|---|
| KW-0130 | Cell adhesion |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0358 | Heparin-binding |
| KW-0378 | Hydrolase |
| KW-0393 | Immunoglobulin domain |
| KW-0472 | Membrane |
| KW-0597 | Phosphoprotein |
| KW-0904 | Protein phosphatase |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| InterPro ID | InterPro Term |
|---|---|
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR029021 | Prot-tyrosine_phosphatase-like |
| IPR000242 | PTPase_domain |
| IPR016130 | Tyr_Pase_AS |
| IPR003595 | Tyr_Pase_cat |
| IPR000387 | TYR_PHOSPHATASE_dom |