| Tag | Content |
|---|---|
| Uniprot ID | B0BMY7 |
| Entrez ID | 684352 |
| Genbank protein ID | AAI58615.1; EDL77328.1; |
| Genbank nucleotide ID | NM_001135238.1 |
| Ensembl protein ID | ENSRNOP00000066595 |
| Ensembl nucleotide ID | ENSRNOG00000048915 |
| Gene name | Protein tyrosine kinase 9-like (A6-related protein) (Predicted), isoform CRA_b |
| Gene symbol | Twf2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAHQTGIHAT EELKEFFAKA RAGSIRLIKV IIEDEQLVLG ASQEPVGRWD QDYDRAVLPL 60 LDAQEPCYLL FRLDSQNAQG FEWLFLAWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE 120 LFGTVKDDLS LAGYQKHLSS CAAPAPLTSA ERELQQIRIN EVKTEISVES KHQTLQGLAF 180 PLQPEAQRAL QQLKQKTVNY IQLKLDLERE TIELVHTEPT NVAQLPSRVP RDAARYHFFL 240 YKHTHEGDSL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DSVEQDFQLE IAKKIEIGDG 300 AELTAEFLYD EVHPKQHAFK QAFAKPKGPG GKRGHKRLIR GPGENGEDS 349 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TWF2 | 282024 | A2VDX0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TWF2 | E2RGD3 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TWF2 | 102173426 | A0A452EMB1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TWF2 | 11344 | Q6IBS0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Twf2 | 23999 | Q9Z0P5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TWF2 | H2QMR1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 106504190 | A0A4X1VPA1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TWF2 | G1TX74 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Twf2 | 684352 | B0BMY7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005884 | actin filament |
| GO:0005623 | cell |
| GO:0005737 | cytoplasm |
| GO:0030175 | filopodium |
| GO:0030426 | growth cone |
| GO:0030027 | lamellipodium |
| GO:0030016 | myofibril |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0032420 | stereocilium |
| GO:0051015 | actin filament binding |
| GO:0003785 | actin monomer binding |
| GO:0005524 | ATP binding |
| GO:0016301 | kinase activity |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0005080 | protein kinase C binding |
| GO:0030042 | actin filament depolymerization |
| GO:0051016 | barbed-end actin filament capping |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0071300 | cellular response to retinoic acid |
| GO:0030837 | negative regulation of actin filament polymerization |
| GO:0045773 | positive regulation of axon extension |
| GO:0010592 | positive regulation of lamellipodium assembly |
| GO:0010976 | positive regulation of neuron projection development |
| GO:0032956 | regulation of actin cytoskeleton organization |
| GO:0010591 | regulation of lamellipodium assembly |
| GO:0042989 | sequestering of actin monomers |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51263 | ADF_H |
| Pfam ID | Pfam Term |
|---|---|
| PF00241 | Cofilin_ADF |