| Tag | Content |
|---|---|
| Uniprot ID | G1TX74 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSOCUP00000021674 |
| Ensembl nucleotide ID | ENSOCUG00000021993 |
| Gene name | Twinfilin actin binding protein 2 |
| Gene symbol | TWF2 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAHQTGIHAT EELKEFFAKA RAGSVRLIKV VIEDEQLMLG ASREPVGRWD QDYDRAVLPL 60 LDAQQPCYLL YRLDSHNAQG FEWIFLAWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE 120 LFGTVKDDLS LAGYQKHLSS CAAPAPLTSA ERELQQIRIN EVKTEISVES KRQTLQGLAF 180 PLQPEAQRAI QQLRQKTINY IQLKLDLERE TIELVHTEPT DVAQLPSRVP RDSARYHFFL 240 YKHTHEGDPL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DSVEQDFQLQ ISKKIEIGDG 300 AELTAEFLYD EVHPKQQAFK PAFAKPKGPG GKRGHKRLIR GPGENGDDS 349 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TWF2 | 282024 | A2VDX0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TWF2 | E2RGD3 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TWF2 | 102173426 | A0A452EMB1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TWF2 | 11344 | Q6IBS0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Twf2 | 23999 | Q9Z0P5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TWF2 | H2QMR1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 106504190 | A0A4X1VPA1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TWF2 | G1TX74 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Twf2 | 684352 | B0BMY7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030175 | filopodium |
| GO:0030426 | growth cone |
| GO:0030027 | lamellipodium |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0032420 | stereocilium |
| GO:0003785 | actin monomer binding |
| GO:0005524 | ATP binding |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0005080 | protein kinase C binding |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0071300 | cellular response to retinoic acid |
| GO:0030837 | negative regulation of actin filament polymerization |
| GO:0045773 | positive regulation of axon extension |
| GO:0010592 | positive regulation of lamellipodium assembly |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51263 | ADF_H |
| Pfam ID | Pfam Term |
|---|---|
| PF00241 | Cofilin_ADF |