Gene: TWF2

Basic information

Tag Content
Uniprot ID H2QMR1
Entrez ID
Genbank protein ID JAA13432.1; JAA01075.1; JAA34930.1; JAA31345.1;
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000025882
Ensembl nucleotide ID ENSPTRG00000042003
Gene name Twinfilin actin binding protein 2
Gene symbol TWF2
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAHQTGIHAT EELKEFFAKA RAGSVRLIKV VIEDEQLVLG ASQELVGRWD QDYDRAVLPL 60
LDAQQPCYLL YRLDSQNAQG FEWLFLAWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE 120
LFGTVKDDLS FAGYQKHLSS CAAPAPLTSA ERELQQIRIN EVKTEISVES KHQTLQGLAF 180
PLQPEAQRAL QQLKQKMVNY IQMKLDLERE TIELVHTEPT DVAQLPSRVP RDAARYHFFL 240
YKHTHEGDPL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DSVEQDFHLE IAKKIEIGDG 300
AELTAEFLYD EVHPKQHAFK QAFAKPKGPG GKRGHKRLIR GPGENGDDS 349

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTWF2282024A2VDX0Bos taurusPredictionMore>>
1:1 orthologTWF2E2RGD3Canis lupus familiarisPredictionMore>>
1:1 orthologTWF2102173426A0A452EMB1Capra hircusPredictionMore>>
1:1 orthologTWF211344Q6IBS0Homo sapiensPredictionMore>>
1:1 orthologTwf223999Q9Z0P5CPOMus musculusPublicationMore>>
1:1 orthologTWF2H2QMR1Pan troglodytesPredictionMore>>
1:1 ortholog106504190A0A4X1VPA1Sus scrofaPredictionMore>>
1:1 orthologTWF2G1TX74Oryctolagus cuniculusPredictionMore>>
1:1 orthologTwf2684352B0BMY7Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005884 actin filament
GO:0005623 cell
GO:0005737 cytoplasm
GO:0030175 filopodium
GO:0030426 growth cone
GO:0030027 lamellipodium
GO:0030016 myofibril
GO:0048471 perinuclear region of cytoplasm
GO:0032420 stereocilium
GO:0051015 actin filament binding
GO:0003785 actin monomer binding
GO:0005524 ATP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005080 protein kinase C binding
GO:0030042 actin filament depolymerization
GO:0051016 barbed-end actin filament capping
GO:0071363 cellular response to growth factor stimulus
GO:0071300 cellular response to retinoic acid
GO:0045773 positive regulation of axon extension
GO:0010592 positive regulation of lamellipodium assembly
GO:0010976 positive regulation of neuron projection development
GO:0010591 regulation of lamellipodium assembly
GO:0042989 sequestering of actin monomers

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR028458 Twinfilin

PROSITE

PROSITE ID PROSITE Term
PS51263 ADF_H

Pfam

Pfam ID Pfam Term
PF00241 Cofilin_ADF