| Tag | Content |
|---|---|
| Uniprot ID | Q9Z0P5; Q3TD06; Q3TZG2; Q8BN77; Q9DCK8; |
| Entrez ID | 23999 |
| Genbank protein ID | BAC39101.1; BAB22293.1; BAE34246.1; AAH03338.1; CAB38083.1; AAP31405.1; BAE39103.1; BAE41799.1; BAC39867.1; BAE33117.1; |
| Genbank nucleotide ID | NM_011876.3 |
| Ensembl protein ID | ENSMUSP00000024047; ENSMUSP00000140339; |
| Ensembl nucleotide ID | ENSMUSG00000023277 |
| Gene name | Twinfilin-2 |
| Gene symbol | Twf2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25807483 |
| Functional description | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. |
| Sequence | MAHQTGIHAT EELKEFFAKA RAGSIRLIKV IIEDEQLVLG ASQEPVGRWD QDYDRAVLPL 60 LDAQEPCYLL FRLDSQNAQG FEWLFLAWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE 120 LFGTVKDDLS LAGYQKHLSS CAAPAPLTSA ERELQQIRIN EVKTEISVES KHQTLQGLAF 180 PLQPEAQRAL QQLKQKTVNY IQLKLDLERE TIELVHTEPT NVAQLPSRIP RDAARYHFFL 240 YKHTHEGDAL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DSVEQDFQLE IAKKIEIGDG 300 AELTAEFLYD EVHPKQHAFK QAFAKPKGPG GKRGHKRLIR GPGENGEDS 349 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TWF2 | 282024 | A2VDX0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TWF2 | E2RGD3 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TWF2 | 102173426 | A0A452EMB1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TWF2 | 11344 | Q6IBS0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Twf2 | 23999 | Q9Z0P5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TWF2 | H2QMR1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 106504190 | A0A4X1VPA1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TWF2 | G1TX74 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Twf2 | 684352 | B0BMY7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003785 | actin monomer binding | IDA |
| GO:0003785 | actin monomer binding | IBA |
| GO:0005080 | protein kinase C binding | ISO |
| GO:0005524 | ATP binding | ISO |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IDA |
| GO:0051015 | actin filament binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0010591 | regulation of lamellipodium assembly | IBA |
| GO:0010592 | positive regulation of lamellipodium assembly | ISO |
| GO:0010976 | positive regulation of neuron projection development | ISO |
| GO:0010976 | positive regulation of neuron projection development | IBA |
| GO:0030030 | cell projection organization | IEA |
| GO:0030042 | actin filament depolymerization | IBA |
| GO:0030837 | negative regulation of actin filament polymerization | IDA |
| GO:0032532 | regulation of microvillus length | IC |
| GO:0032956 | regulation of actin cytoskeleton organization | ISO |
| GO:0035556 | intracellular signal transduction | ISO |
| GO:0042989 | sequestering of actin monomers | IBA |
| GO:0045773 | positive regulation of axon extension | ISO |
| GO:0051016 | barbed-end actin filament capping | IBA |
| GO:0071300 | cellular response to retinoic acid | ISO |
| GO:0071363 | cellular response to growth factor stimulus | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IBA |
| GO:0005884 | actin filament | IBA |
| GO:0030016 | myofibril | IBA |
| GO:0030027 | lamellipodium | IDA |
| GO:0030175 | filopodium | IDA |
| GO:0030426 | growth cone | ISO |
| GO:0032420 | stereocilium | IDA |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0009 | Actin-binding |
| KW-0877 | Alternative promoter usage |
| KW-0966 | Cell projection |
| KW-0970 | Cilium biogenesis/degradation |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0217 | Developmental protein |
| KW-0903 | Direct protein sequencing |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51263 | ADF_H |
| Pfam ID | Pfam Term |
|---|---|
| PF00241 | Cofilin_ADF |