Gene: EFNB2

Basic information

Tag Content
Uniprot ID B0LDS7; F6SYV2;
Entrez ID 100064730
Genbank protein ID ABV44488.1
Genbank nucleotide ID NM_001114943.1
Ensembl protein ID ENSECAP00000010214
Ensembl nucleotide ID ENSECAG00000012348
Gene name Ephrin-B2
Gene symbol EFNB2
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAARRDSLWK YCWGVLMVLC RTAISRSIVL EPIYWNSSNS KFLPGQGLVL YPQIGDKLDI 60
ICPKVDSKTV GQYEYYKVYM VDKDQADRCT IKKENTPLLN CARPDQDVKF TIKFQEFSPN 120
LWGLEFQKNR DYYIISTSNG SLEGLDNQEG GVCQTRAMKI LMKVGQDASS AGSPRHNDPT 180
RRPELEAGTN GRSSTTSPFV KPNPGSSTDG NSAGHSGNNI LGSEVALFAG IASGCIIFIV 240
IIITLVVLLL KYRRRHRKHS PQHTATLSLS TLATPKRSGN NNGSEPSDII IPLRTADSVF 300
CPHYEKVSGD YGHPVYIVQE MPPQSPANIY YKV 333

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEFNB2A0A5F4CFF7Canis lupus familiarisPredictionMore>>
1:1 orthologEFNB2A0A452FDT3Capra hircusPredictionMore>>
1:1 orthologEFNB2100064730B0LDS7Equus caballusPredictionMore>>
1:1 orthologEFNB21948P52799Homo sapiensPredictionMore>>
1:1 orthologEfnb213642P52800CPOMus musculusPublicationMore>>
1:1 orthologEFNB2735430H2Q7S4Pan troglodytesPredictionMore>>
1:1 orthologEFNB2G1TLS5Oryctolagus cuniculusPredictionMore>>
1:1 orthologEfnb2306636B2B9A9Rattus norvegicusPredictionMore>>
1:1 orthologefnb2a30219O73874Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0005886 plasma membrane
GO:0046875 ephrin receptor binding
GO:0007155 cell adhesion
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0048013 ephrin receptor signaling pathway
GO:0010977 negative regulation of neuron projection development
GO:0008284 positive regulation of cell population proliferation
GO:1901216 positive regulation of neuron death
GO:0050920 regulation of chemotaxis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0472 Membrane
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034255 Ephrin-B_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD

PROSITE

PROSITE ID PROSITE Term
PS01299 EPHRIN_RBD_1
PS51551 EPHRIN_RBD_2

Pfam

Pfam ID Pfam Term
PF00812 Ephrin