| Tag | Content |
|---|---|
| Uniprot ID | P52800 |
| Entrez ID | 13642 |
| Genbank protein ID | AAA82934.1; AAH57009.1; AAC42052.1; AAA99708.1; |
| Genbank nucleotide ID | NM_010111.5 |
| Ensembl protein ID | ENSMUSP00000001319 |
| Ensembl nucleotide ID | ENSMUSG00000001300 |
| Gene name | Ephrin-B2 |
| Gene symbol | Efnb2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 15223333 |
| Functional description | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. |
| Sequence | MAMARSRRDS VWKYCWGLLM VLCRTAISRS IVLEPIYWNS SNSKFLPGQG LVLYPQIGDK 60 LDIICPKVDS KTVGQYEYYK VYMVDKDQAD RCTIKKENTP LLNCARPDQD VKFTIKFQEF 120 SPNLWGLEFQ KNKDYYIIST SNGSLEGLDN QEGGVCQTRA MKILMKVGQD ASSAGSARNH 180 GPTRRPELEA GTNGRSSTTS PFVKPNPGSS TDGNSAGHSG NNLLGSEVAL FAGIASGCII 240 FIVIIITLVV LLLKYRRRHR KHSPQHTTTL SLSTLATPKR GGNNNGSEPS DVIIPLRTAD 300 SVFCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV 336 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EFNB2 | A0A5F4CFF7 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | EFNB2 | A0A452FDT3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | EFNB2 | 100064730 | B0LDS7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | EFNB2 | 1948 | P52799 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Efnb2 | 13642 | P52800 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EFNB2 | 735430 | H2Q7S4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EFNB2 | G1TLS5 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Efnb2 | 306636 | B2B9A9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | efnb2a | 30219 | O73874 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0046875 | ephrin receptor binding | ISO |
| GO:0046875 | ephrin receptor binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001945 | lymph vessel development | IMP |
| GO:0002042 | cell migration involved in sprouting angiogenesis | ISS |
| GO:0002042 | cell migration involved in sprouting angiogenesis | ISO |
| GO:0007155 | cell adhesion | ISS |
| GO:0007155 | cell adhesion | ISO |
| GO:0007411 | axon guidance | IBA |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0010839 | negative regulation of keratinocyte proliferation | IMP |
| GO:0010977 | negative regulation of neuron projection development | ISO |
| GO:0031295 | T cell costimulation | IDA |
| GO:0034332 | adherens junction organization | IDA |
| GO:0048013 | ephrin receptor signaling pathway | ISS |
| GO:0048013 | ephrin receptor signaling pathway | ISO |
| GO:0048013 | ephrin receptor signaling pathway | IBA |
| GO:0048514 | blood vessel morphogenesis | IMP |
| GO:0048514 | blood vessel morphogenesis | IBA |
| GO:0048845 | venous blood vessel morphogenesis | IMP |
| GO:0050920 | regulation of chemotaxis | ISS |
| GO:0050920 | regulation of chemotaxis | ISO |
| GO:0072178 | nephric duct morphogenesis | IMP |
| GO:0099054 | presynapse assembly | ISO |
| GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | IDA |
| GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | IMP |
| GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization | IDA |
| GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization | IMP |
| GO:1901216 | positive regulation of neuron death | ISO |
| GO:1903849 | positive regulation of aorta morphogenesis | IMP |
| GO:2000727 | positive regulation of cardiac muscle cell differentiation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | IBA |
| GO:0005886 | plasma membrane | TAS |
| GO:0005912 | adherens junction | IEA |
| GO:0098685 | Schaffer collateral - CA1 synapse | IDA |
| GO:0098685 | Schaffer collateral - CA1 synapse | IMP |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0098978 | glutamatergic synapse | IMP |
| GO:0099056 | integral component of presynaptic membrane | ISO |
| GO:0099061 | integral component of postsynaptic density membrane | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-2682334 | EPH-Ephrin signaling | IEA |
| R-MMU-3928662 | EPHB-mediated forward signaling | IEA |
| R-MMU-3928664 | Ephrin signaling | IEA |
| R-MMU-3928665 | EPH-ephrin mediated repulsion of cells | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0037 | Angiogenesis |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0488 | Methylation |
| KW-0524 | Neurogenesis |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF00812 | Ephrin |