| Tag | Content |
|---|---|
| Uniprot ID | O73874 |
| Entrez ID | 30219 |
| Genbank protein ID | CAA06168.1; AAK64275.1; |
| Genbank nucleotide ID | NM_131023.1 |
| Ensembl protein ID | ENSDARP00000010432 |
| Ensembl nucleotide ID | ENSDARG00000020164 |
| Gene name | Ephrin-B2a |
| Gene symbol | efnb2a |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration (By similarity). |
| Sequence | MGDSLWRYYF GVLVIACKVN LSRALILDSI YWNTTNTKFV PGQGLVLYPQ IGDKMDIVCP 60 RVEGGSMEGV EYYKLYMVPL EQLKSCQVTK ADTPLLNCVK PDQDVKFTLK FQEFSPNLWG 120 LEFFRGKDYY IISTSNGTME GLDNQEGGVC KTKSMKIIMK VGQNPSDPIS PKDYPTSYPP 180 KHPDLGGKDS KSNEVLKPDA SPHGEDKGDG NKSSSVIGSE VALFACIASA SVIVIIIIIM 240 LVFLLLKYRR RHRKHSPQHA TTLSLSTLAT PKRGGSGGNN NGSEPSDIII PLRTADSVFC 300 PHYEKVSGDY GHPVYIVQEM PPQSPANIYY KV 332 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EFNB2 | A0A5F4CFF7 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | EFNB2 | A0A452FDT3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | EFNB2 | 100064730 | B0LDS7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | EFNB2 | 1948 | P52799 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Efnb2 | 13642 | P52800 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EFNB2 | 735430 | H2Q7S4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EFNB2 | G1TLS5 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Efnb2 | 306636 | B2B9A9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | efnb2a | 30219 | O73874 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0046875 | ephrin receptor binding |
| GO:0035475 | angioblast cell migration involved in selective angioblast sprouting |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0007411 | axon guidance |
| GO:0007412 | axon target recognition |
| GO:0001568 | blood vessel development |
| GO:0048514 | blood vessel morphogenesis |
| GO:0007155 | cell adhesion |
| GO:0002042 | cell migration involved in sprouting angiogenesis |
| GO:0048013 | ephrin receptor signaling pathway |
| GO:0003404 | optic vesicle morphogenesis |
| GO:0050920 | regulation of chemotaxis |
| GO:0021654 | rhombomere boundary formation |
| GO:0001756 | somitogenesis |
| GO:0008039 | synaptic target recognition |
| Keyword ID | Keyword Term |
|---|---|
| KW-0037 | Angiogenesis |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0524 | Neurogenesis |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF00812 | Ephrin |