| Tag | Content |
|---|---|
| Uniprot ID | B0R0I1 |
| Entrez ID | 566945 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005171310.3 |
| Ensembl protein ID | ENSDARP00000044263 |
| Ensembl nucleotide ID | ENSDARG00000008388 |
| Gene name | Matrix metallopeptidase 14b (membrane-inserted) |
| Gene symbol | mmp14b |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MIWSGFTRLL LLIFVCAHRS SSKQDMKPEA WLQQYGYLPP GDLRTHTARS PQSVPSAIAA 60 MQRFYGLTVT GNLDANTLEA MKRPRCGVPD KFGSELKSNL RKKRYAIQGL KWDKNEITFC 120 IQNYTPKVGE YETFEAIRKA FKVWESVTPL RFREISYSDI RDKVVDFADI MLFFADGFHG 180 DASPFDGEGG FLAHAYFPGN GIGGDTHFDA AEPWTIGNKD LLGNDVFLVA VHELGHALGM 240 EHSNDPSAIM APFYQWMETD HFVLPDDDRK GIQKLYGPGS GGHPRTPVTP ETPHHTPYPT 300 PYRPGGPSYG PNICEGHFDT IGIFRGEMFV FKGKWFWRVR NNQVMENYPM PIGHFWRGLP 360 TDINAAYERE DGKFVFFKGD RHWVFTESNL EPGYPKVLGE LGSGVPKDKL DAALLYTPTG 420 YTYFFRGNKY YRYNEDTHSV DPDYPKPISK WQGVPDNIKA AFMSRDQGYT YFYKANKYWK 480 FNNQLLKVEP GYPKSALKDW MGCPNEDSNT GGGGSDRDRE RERERERERE RERERARERE 540 REQDRTNEVD KTEEEGKKEE TEVLIIEVED APSSRGGAAA VVVPLMLLVC VIFTLGALLF 600 FRRYGTPRRL LYCQRSLLDK V 621 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP14 | 403823 | F1PXM2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A452E6Q2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP14 | 4323 | P50281 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mmp14 | 17387 | P53690 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MMP14 | 742887 | H2Q7Z4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A287A740 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp14 | 81707 | Q10739 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mmp14b | 566945 | B0R0I1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0016021 | integral component of membrane |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008237 | metallopeptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0009948 | anterior/posterior axis specification |
| GO:0051216 | cartilage development |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0030574 | collagen catabolic process |
| GO:0060026 | convergent extension |
| GO:0060027 | convergent extension involved in gastrulation |
| GO:0001958 | endochondral ossification |
| GO:0030010 | establishment of cell polarity |
| GO:0030198 | extracellular matrix organization |
| GO:0001957 | intramembranous ossification |
| GO:0001501 | skeletal system development |
| GO:0031638 | zymogen activation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0378 | Hydrolase |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0482 | Metalloprotease |
| KW-0645 | Protease |
| KW-1267 | Proteomics identification |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0862 | Zinc |
| KW-0865 | Zymogen |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021805 | Pept_M10A_metallopeptidase_C |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |