Gene: MMP14

Basic information

Tag Content
Uniprot ID F1PXM2
Entrez ID 403823
Genbank protein ID
Genbank nucleotide ID XM_851854.4
Ensembl protein ID ENSCAFP00000016472
Ensembl nucleotide ID ENSCAFG00000011197
Gene name Matrix metallopeptidase 14
Gene symbol MMP14
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSPAPRPAGG RLLPLLTLAT ALASLSSAQS SFSPEAWLQQ YGYLPPGDLR THTQRSPQSF 60
SAAIAAMQKF YGLRVTGKAD ADTMKAMRRP RCGVPDKFGA EIKANVRRKR YAIQGLKWQH 120
NEITFCIQNY TPKVGEYATF EAIRKAFRVW ESATPLRFRE VPYAYIREGH EKQADIMIFF 180
AEGFHGDSTP FDGEGGFLAH AYFPGPNIGG DTHFDSAEPW TVRNEDLNGN DIFLVAVHEL 240
GHALGLEHSN DPSAIMAPFY QWMDTENFVL PDDDRRGIQQ LYGSESGSPT KMPPQPRTTS 300
RPSVPDKPKN PTYGPNICDG NFDTVAVLRG EMFVFKERWF WRVRNNQVMD GYPMPIGQFW 360
RGLPASINTA YERKDGKFVF FKGDKHWVFD EASLEPGYPK HIKELGRGLP TDKIDAALFW 420
MPNGKTYFFR GNKYYRFNEE LRAVDSEYPK NIKVWEGIPE SPRGSFMGSD EVFTYFYKGN 480
KYWKFNNQKL KVEPGYPKSA LRDWMGCPSS GSRPDEGTEE ETEVIIIEVD EEGSGAVSAA 540
AVVLPVLLLL LVLAVGLAVF FFRRHGTPKR LLYCQRSLLD KV 582

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMMP14403823F1PXM2Canis lupus familiarisPredictionMore>>
1:1 orthologMMP14A0A452E6Q2Capra hircusPredictionMore>>
1:1 orthologMMP144323P50281Homo sapiensPredictionMore>>
1:1 orthologMmp1417387P53690CPOMus musculusPublicationMore>>
1:1 orthologMMP14742887H2Q7Z4Pan troglodytesPredictionMore>>
1:1 orthologMMP14A0A287A740Sus scrofaPredictionMore>>
1:1 orthologMmp1481707Q10739Rattus norvegicusPredictionMore>>
1:1 orthologmmp14b566945B0R0I1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0005615 extracellular space
GO:0016021 integral component of membrane
GO:0045111 intermediate filament cytoskeleton
GO:0044354 macropinosome
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0070006 metalloaminopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
GO:0048754 branching morphogenesis of an epithelial tube
GO:0016477 cell migration
GO:0035988 chondrocyte proliferation
GO:0030574 collagen catabolic process
GO:0097094 craniofacial suture morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0001958 endochondral ossification
GO:0035987 endodermal cell differentiation
GO:0030198 extracellular matrix organization
GO:0060322 head development
GO:0030324 lung development
GO:0045746 negative regulation of Notch signaling pathway
GO:0045579 positive regulation of B cell differentiation
GO:0030307 positive regulation of cell growth
GO:1905523 positive regulation of macrophage migration
GO:0010831 positive regulation of myotube differentiation
GO:1903076 regulation of protein localization to plasma membrane
GO:0001501 skeletal system development
GO:0031638 zymogen activation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0106 Calcium
KW-1015 Disulfide bond
KW-0378 Hydrolase
KW-0472 Membrane
KW-0479 Metal-binding
KW-0482 Metalloprotease
KW-0645 Protease
KW-1185 Reference proteome
KW-0677 Repeat
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0862 Zinc

Interpro

InterPro ID InterPro Term
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021805 Pept_M10A_metallopeptidase_C
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf

PROSITE

PROSITE ID PROSITE Term
PS00546 CYSTEINE_SWITCH
PS00024 HEMOPEXIN
PS51642 HEMOPEXIN_2

Pfam

Pfam ID Pfam Term
PF11857 DUF3377
PF00045 Hemopexin
PF00413 Peptidase_M10
PF01471 PG_binding_1