| Tag | Content |
|---|---|
| Uniprot ID | Q10739; Q6IN06; |
| Entrez ID | 81707 |
| Genbank protein ID | AAH72509.1; CAA58521.1; CAA62897.1; |
| Genbank nucleotide ID | NM_031056.1 |
| Ensembl protein ID | ENSRNOP00000065434 |
| Ensembl nucleotide ID | ENSRNOG00000010947 |
| Gene name | Matrix metalloproteinase-14 |
| Gene symbol | Mmp14 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. |
| Sequence | MSPAPRPSRS LLLPLLTLGT TLASLGWAQS SNFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 60 LSAAIAAMQR FYGLQVTGKA DSDTMKAMRR PRCGVPDKFG TEIKANVRRK RYAIQGLKWQ 120 HNEITFCIQN YTPKVGEYAT FEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIL 180 FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVQNEDLNG NDIFLVAVHE 240 LGHALGLEHS NDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGSKSGSP TKMPPQPRTT 300 SRPSVPDKPR NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 360 WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 420 WMPNGKTYFF RGNKYYRFNE EFRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 480 NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGSGAVSAA 540 AVVLPVLLLL LVLAVGLAVF FFRRHGTPKR LLYCQRSLLD KV 582 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP14 | 403823 | F1PXM2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A452E6Q2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP14 | 4323 | P50281 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mmp14 | 17387 | P53690 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MMP14 | 742887 | H2Q7Z4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A287A740 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp14 | 81707 | Q10739 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mmp14b | 566945 | B0R0I1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005829 | cytosol |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0016021 | integral component of membrane |
| GO:0045111 | intermediate filament cytoskeleton |
| GO:0044354 | macropinosome |
| GO:0042470 | melanosome |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0004175 | endopeptidase activity |
| GO:0005178 | integrin binding |
| GO:0070006 | metalloaminopeptidase activity |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0001525 | angiogenesis |
| GO:0043615 | astrocyte cell migration |
| GO:0060348 | bone development |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0016477 | cell migration |
| GO:0035988 | chondrocyte proliferation |
| GO:0030574 | collagen catabolic process |
| GO:0097094 | craniofacial suture morphogenesis |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0001958 | endochondral ossification |
| GO:0035987 | endodermal cell differentiation |
| GO:0001935 | endothelial cell proliferation |
| GO:0030198 | extracellular matrix organization |
| GO:0060322 | head development |
| GO:0030324 | lung development |
| GO:0008584 | male gonad development |
| GO:0051895 | negative regulation of focal adhesion assembly |
| GO:0045746 | negative regulation of Notch signaling pathway |
| GO:0001503 | ossification |
| GO:0001541 | ovarian follicle development |
| GO:0045579 | positive regulation of B cell differentiation |
| GO:0030307 | positive regulation of cell growth |
| GO:0030335 | positive regulation of cell migration |
| GO:1905523 | positive regulation of macrophage migration |
| GO:0010831 | positive regulation of myotube differentiation |
| GO:0010954 | positive regulation of protein processing |
| GO:0006508 | proteolysis |
| GO:1903076 | regulation of protein localization to plasma membrane |
| GO:0043627 | response to estrogen |
| GO:0009725 | response to hormone |
| GO:0001666 | response to hypoxia |
| GO:0009612 | response to mechanical stimulus |
| GO:1990834 | response to odorant |
| GO:0014070 | response to organic cyclic compound |
| GO:0006979 | response to oxidative stress |
| GO:0001501 | skeletal system development |
| GO:0048771 | tissue remodeling |
| GO:0031638 | zymogen activation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0963 | Cytoplasm |
| KW-1015 | Disulfide bond |
| KW-0378 | Hydrolase |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0482 | Metalloprotease |
| KW-0597 | Phosphoprotein |
| KW-0645 | Protease |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0862 | Zinc |
| KW-0865 | Zymogen |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021805 | Pept_M10A_metallopeptidase_C |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |