| Tag | Content |
|---|---|
| Uniprot ID | P53690; O08645; O35369; Q8BTX2; |
| Entrez ID | 17387 |
| Genbank protein ID | BAE29216.1; EDL36348.1; ABB45784.1; AAB51753.1; CAA58520.2; AAB86602.1; BAE29158.1; BAC40377.1; BAE23719.1; BAE38000.1; |
| Genbank nucleotide ID | NM_008608.4 |
| Ensembl protein ID | ENSMUSP00000087119 |
| Ensembl nucleotide ID | ENSMUSG00000000957 |
| Gene name | Matrix metalloproteinase-14 |
| Gene symbol | Mmp14 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 18022611 |
| Functional description | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues (By similarity). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By similarity). |
| Sequence | MSPAPRPSRS LLLPLLTLGT ALASLGWAQG SNFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 60 LSAAIAAMQK FYGLQVTGKA DLATMMAMRR PRCGVPDKFG TEIKANVRRK RYAIQGLKWQ 120 HNEITFCIQN YTPKVGEYAT FEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIL 180 FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVQNEDLNG NDIFLVAVHE 240 LGHALGLEHS NDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGSKSGSP TKMPPQPRTT 300 SRPSVPDKPK NPAYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 360 WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 420 WMPNGKTYFF RGNKYYRFNE EFRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 480 NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGSGAVSAA 540 AVVLPVLLLL LVLAVGLAVF FFRRHGTPKR LLYCQRSLLD KV 582 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP14 | 403823 | F1PXM2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A452E6Q2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP14 | 4323 | P50281 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mmp14 | 17387 | P53690 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MMP14 | 742887 | H2Q7Z4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A287A740 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp14 | 81707 | Q10739 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mmp14b | 566945 | B0R0I1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004175 | endopeptidase activity | ISO |
| GO:0004222 | metalloendopeptidase activity | IDA |
| GO:0004222 | metalloendopeptidase activity | IBA |
| GO:0004222 | metalloendopeptidase activity | IMP |
| GO:0005178 | integrin binding | ISO |
| GO:0008270 | zinc ion binding | IEA |
| GO:0070006 | metalloaminopeptidase activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IBA |
| GO:0001503 | ossification | IGI |
| GO:0001525 | angiogenesis | IEA |
| GO:0001541 | ovarian follicle development | IEA |
| GO:0001666 | response to hypoxia | IEA |
| GO:0001935 | endothelial cell proliferation | IEA |
| GO:0001958 | endochondral ossification | IGI |
| GO:0006508 | proteolysis | ISO |
| GO:0006979 | response to oxidative stress | IEA |
| GO:0008584 | male gonad development | IEA |
| GO:0009612 | response to mechanical stimulus | IEA |
| GO:0009725 | response to hormone | ISO |
| GO:0010831 | positive regulation of myotube differentiation | IMP |
| GO:0010954 | positive regulation of protein processing | ISO |
| GO:0014070 | response to organic cyclic compound | IEA |
| GO:0016477 | cell migration | IMP |
| GO:0030198 | extracellular matrix organization | IBA |
| GO:0030307 | positive regulation of cell growth | ISO |
| GO:0030324 | lung development | IMP |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0030574 | collagen catabolic process | IGI |
| GO:0030574 | collagen catabolic process | IBA |
| GO:0031638 | zymogen activation | ISO |
| GO:0031638 | zymogen activation | IMP |
| GO:0031638 | zymogen activation | IBA |
| GO:0035987 | endodermal cell differentiation | IEA |
| GO:0035988 | chondrocyte proliferation | IGI |
| GO:0043615 | astrocyte cell migration | IEA |
| GO:0043627 | response to estrogen | IEA |
| GO:0045579 | positive regulation of B cell differentiation | IMP |
| GO:0045746 | negative regulation of Notch signaling pathway | IMP |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IGI |
| GO:0048754 | branching morphogenesis of an epithelial tube | IMP |
| GO:0048771 | tissue remodeling | ISO |
| GO:0051895 | negative regulation of focal adhesion assembly | ISO |
| GO:0060322 | head development | IMP |
| GO:0060348 | bone development | IGI |
| GO:0097094 | craniofacial suture morphogenesis | IGI |
| GO:1903076 | regulation of protein localization to plasma membrane | ISO |
| GO:1905523 | positive regulation of macrophage migration | IMP |
| GO:1990834 | response to odorant | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IBA |
| GO:0005634 | nucleus | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0016021 | integral component of membrane | IEA |
| GO:0031012 | extracellular matrix | IEA |
| GO:0031410 | cytoplasmic vesicle | ISO |
| GO:0042470 | melanosome | IEA |
| GO:0044354 | macropinosome | ISO |
| GO:0045111 | intermediate filament cytoskeleton | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1442490 | Collagen degradation | IEA |
| R-MMU-1474228 | Degradation of the extracellular matrix | IEA |
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1592389 | Activation of Matrix Metalloproteinases | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0177 | Collagen degradation |
| KW-0963 | Cytoplasm |
| KW-1015 | Disulfide bond |
| KW-0378 | Hydrolase |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0482 | Metalloprotease |
| KW-0597 | Phosphoprotein |
| KW-0645 | Protease |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0862 | Zinc |
| KW-0865 | Zymogen |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021805 | Pept_M10A_metallopeptidase_C |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |