| Tag | Content |
|---|---|
| Uniprot ID | H2Q7Z4; A0A2J8QJR0; |
| Entrez ID | 742887 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_001157686.5 |
| Ensembl protein ID | ENSPTRP00000010422 |
| Ensembl nucleotide ID | ENSPTRG00000006148 |
| Gene name | Matrix metallopeptidase 14 |
| Gene symbol | MMP14 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSPAPRPSRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 60 LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ 120 HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF 180 FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE 240 LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT 300 SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 360 WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 420 WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 480 NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA 540 AVVLPVLLLL LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV 582 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP14 | 403823 | F1PXM2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A452E6Q2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP14 | 4323 | P50281 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mmp14 | 17387 | P53690 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MMP14 | 742887 | H2Q7Z4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP14 | A0A287A740 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp14 | 81707 | Q10739 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mmp14b | 566945 | B0R0I1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0016021 | integral component of membrane |
| GO:0045111 | intermediate filament cytoskeleton |
| GO:0044354 | macropinosome |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0070006 | metalloaminopeptidase activity |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0016477 | cell migration |
| GO:0035988 | chondrocyte proliferation |
| GO:0030574 | collagen catabolic process |
| GO:0097094 | craniofacial suture morphogenesis |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0001958 | endochondral ossification |
| GO:0035987 | endodermal cell differentiation |
| GO:0030198 | extracellular matrix organization |
| GO:0060322 | head development |
| GO:0030324 | lung development |
| GO:0045746 | negative regulation of Notch signaling pathway |
| GO:0045579 | positive regulation of B cell differentiation |
| GO:0030307 | positive regulation of cell growth |
| GO:1905523 | positive regulation of macrophage migration |
| GO:0010831 | positive regulation of myotube differentiation |
| GO:1903076 | regulation of protein localization to plasma membrane |
| GO:0001501 | skeletal system development |
| GO:0031638 | zymogen activation |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021805 | Pept_M10A_metallopeptidase_C |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |