| Tag | Content |
|---|---|
| Uniprot ID | D3ZYB7 |
| Entrez ID | 690450 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001191107.1 |
| Ensembl protein ID | ENSRNOP00000069237 |
| Ensembl nucleotide ID | ENSRNOG00000061415 |
| Gene name | TATA box-binding protein-associated factor RNA polymerase I subunit B |
| Gene symbol | Taf1b |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity). |
| Sequence | MDVEQMKAFT DRCSQCAAVS WGLTDEGKYY CTSCHNVTDR SEEVVSTAVI PNTKINSISR 60 GLRQRSKHEK GWDWYVCEGF QCILYHQAEA LETLGVSPEL KNEVLHSFWK RYLQKSKQAY 120 CKNPVRTSGR KAKVLEDNLQ SSDWGSDFEL LSDTTCPPES GAEFQSDSQT PKPFPATKRS 180 SKSASVCSGS VDGVEYSERK EKGLLKMTVP RTLALCYLSL LWQRETITLS DLLRFVEEDR 240 IPYINAFKVF PEEMKVYGRD KGIFAVESWP DYEDIYKNMI EVAVFLDLPR FPDITEDCYL 300 HPNTLCMKYL LEVNLPEEMY TLTCQVVKLT GIGEVDFLTF DPIAKMTRTV KHDVQAVAVI 360 VLVLKLLFLL DDKLEWSYSD LAEAYNEGHK EETPQFDFRK WYQVMKKTFD EKRRKWEEAR 420 AKYVWKTKRP LYRSHIDKSV AYKRREMVEN LQKQFSALIG SAPEVERQAP SSFQLNWTGE 480 DTGSPCFHGH SLQGLLISKG QALITKNSLY WLSTHKFCKS YCKHVTTYEE SNFSLSYQFI 540 LNIFSFLLRI KTSALHEEVS LLEKKLFEKK YNESKRSSRS KKVRRH 586 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TAF1B | 511236 | Q1JQD6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 100684854 | F1PFZ2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 102186603 | A0A452EIN8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 9014 | Q53T94 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Taf1b | 21340 | P97358 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 459022 | H2QHF2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | F1SA99 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Taf1b | 690450 | D3ZYB7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | taf1b | F1R3W0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0070860 | RNA polymerase I core factor complex |
| GO:0005668 | RNA polymerase transcription factor SL1 complex |
| GO:0046872 | metal ion binding |
| GO:0001164 | RNA polymerase I core promoter sequence-specific DNA binding |
| GO:0042790 | nucleolar large rRNA transcription by RNA polymerase I |
| GO:0001188 | RNA polymerase I preinitiation complex assembly |
| Pfam ID | Pfam Term |
|---|---|
| PF11781 | zf-RRN7 |