| Tag | Content |
|---|---|
| Uniprot ID | P97358; E9QJY7; Q08AT7; Q3V292; Q6NSS9; |
| Entrez ID | 21340 |
| Genbank protein ID | AAH94035.1; AAI25029.1; BAE38271.1; AAH57167.1; BAE41709.1; BAE20906.1; AAH69907.1; AAI25028.1; CAA71092.1; |
| Genbank nucleotide ID | NM_020614.2 |
| Ensembl protein ID | ENSMUSP00000075339 |
| Ensembl nucleotide ID | ENSMUSG00000059669 |
| Gene name | TATA box-binding protein-associated factor RNA polymerase I subunit B |
| Gene symbol | Taf1b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. |
| Sequence | MDVEEVKAFR DRCSQCAAVS WGLTDEGKYY CTSCHNVTDR SEEVVSAADI PNTKINSINR 60 GLRQRSKHEK GWDWYVCEGF QCILYHQAKA LETLGVSPEL KNEVLHNFWK RYLQKSKQAY 120 CKNPVRTSGR KAKVLEDSVQ SSDLGSDLEL LSDTTCPLES EAEFQSDPQI PKPFPVTKGS 180 PKSASVCSGS VDGVEYSERK EKGLVKMTVP RTLALCSLSL LWQRETITVS DLLRFVEEDH 240 IPYINAFKLF PEEMKVYGRD KGIFAIESWP DYEDIYKNMI ELAIFLDLPR FPDITEDCYL 300 HPNTLCMKYL LEVNLPDEMH TLTCQVVKLT GIGEVDFLTF DPIAKTKRTV KYDVQAMAVI 360 VVVLKLLFLL DDKLEWSYSD LAEAYNEQHR EDTPQFDFRK WYQVMKKTFD EKRRKWEEAR 420 ARYAWKTKRP LYRSHIDKSV AYKRRKMVEN LQKQFSALVG SSPVVEKQAP SSFQFNWTEE 480 GTDSPCFHGH SLQGLLIMKG QSMITKNSLY WLSTQKFCKS YCKHVTTYEE SNFSLSYQFI 540 LNIFSFLLRI KTSALHEEVS LLEKKLFEKK YNESKKSSGS KKGRRH 586 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TAF1B | 511236 | Q1JQD6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 100684854 | F1PFZ2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 102186603 | A0A452EIN8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 9014 | Q53T94 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Taf1b | 21340 | P97358 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 459022 | H2QHF2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | F1SA99 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Taf1b | 690450 | D3ZYB7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | taf1b | F1R3W0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001164 | RNA polymerase I core promoter sequence-specific DNA binding | ISS |
| GO:0001164 | RNA polymerase I core promoter sequence-specific DNA binding | ISO |
| GO:0001164 | RNA polymerase I core promoter sequence-specific DNA binding | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001188 | RNA polymerase I preinitiation complex assembly | ISS |
| GO:0001188 | RNA polymerase I preinitiation complex assembly | ISO |
| GO:0006360 | transcription by RNA polymerase I | TAS |
| GO:0042790 | nucleolar large rRNA transcription by RNA polymerase I | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000120 | RNA polymerase I transcription factor complex | TAS |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005668 | RNA polymerase transcription factor SL1 complex | IBA |
| GO:0005730 | nucleolus | ISO |
| GO:0070860 | RNA polymerase I core factor complex | ISO |
| GO:0070860 | RNA polymerase I core factor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-212165 | Epigenetic regulation of gene expression | IEA |
| R-MMU-5250913 | Positive epigenetic regulation of rRNA expression | IEA |
| R-MMU-5250924 | B-WICH complex positively regulates rRNA expression | IEA |
| R-MMU-73762 | RNA Polymerase I Transcription Initiation | IEA |
| R-MMU-73772 | RNA Polymerase I Promoter Escape | IEA |
| R-MMU-73854 | RNA Polymerase I Promoter Clearance | IEA |
| R-MMU-73863 | RNA Polymerase I Transcription Termination | IEA |
| R-MMU-73864 | RNA Polymerase I Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF11781 | zf-RRN7 |