| Tag | Content |
|---|---|
| Uniprot ID | Q1JQD6; E1BGL1; |
| Entrez ID | 511236 |
| Genbank protein ID | AAI16033.1 |
| Genbank nucleotide ID | NM_001075503.1 |
| Ensembl protein ID | ENSBTAP00000041230 |
| Ensembl nucleotide ID | ENSBTAG00000007543 |
| Gene name | TATA box-binding protein-associated factor RNA polymerase I subunit B |
| Gene symbol | TAF1B |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity). |
| Sequence | MDLEEAREFR ERCSQCAAVS WGLTDEGKYY CTSCHNVTER SREVIDTGAI PNTKIQAINR 60 GLKRKRKLEK GWDWYVCEGF QHILYQQAEA LQSLGVGPEL KNEVLHNFWK RYLQKSKQAY 120 CKNPVYTSRR KTTVLEDNLS HSDWESEPEL LSDMSCLSFA ESGAESQPDV RTPKPFPIIK 180 ASHSETTSVC SGSLDGVEYS LRKEKGVMKM SVPRTLAFCY LSLLWQRETI TLSDLLRFVE 240 EEHIPYIHAF QHFPEEMKLY GRDKGIFAIE SWPNYEVIFK KIIEVATFLD LPRFPDITEN 300 CYLHPNILCM KYLMEVNLPD EMHNVTCLVV KSTGIGEVDF LRFDPIAKKA KTVKYDVQAV 360 AVIVVALKLL FLLDDNLEWS LSNIAKKYNE KNKEDKPWFD FRKWYQVMKK AIDEKKQKWE 420 EARAKFLWKG EKPLYYSAID RPVVYKRREM VVSLQKQFST LVDSAPNVEK KKPSSFQFNW 480 TEEDSERPCF HGHSLQGVLQ QKGQSLTTKN SLYWLSTQKF CKSHCKHVTT YEESNFSLSY 540 QFILNLFSFL LRIKTSFLHE EVSLIEKRLF KAKYNKTNKK SSRSRKTRKY |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TAF1B | 511236 | Q1JQD6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 100684854 | F1PFZ2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 102186603 | A0A452EIN8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 9014 | Q53T94 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Taf1b | 21340 | P97358 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | 459022 | H2QHF2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TAF1B | F1SA99 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Taf1b | 690450 | D3ZYB7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | taf1b | F1R3W0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0070860 | RNA polymerase I core factor complex |
| GO:0005668 | RNA polymerase transcription factor SL1 complex |
| GO:0046872 | metal ion binding |
| GO:0001164 | RNA polymerase I core promoter sequence-specific DNA binding |
| GO:0042790 | nucleolar large rRNA transcription by RNA polymerase I |
| GO:0001188 | RNA polymerase I preinitiation complex assembly |
| Pfam ID | Pfam Term |
|---|---|
| PF11781 | zf-RRN7 |