| Tag | Content |
|---|---|
| Uniprot ID | D4ACP5 |
| Entrez ID | 287834 |
| Genbank protein ID | EDM06625.1 |
| Genbank nucleotide ID | NM_001105853.1 |
| Ensembl protein ID | ENSRNOP00000007246 |
| Ensembl nucleotide ID | ENSRNOG00000005107 |
| Gene name | ATP-dependent DNA helicase Q5 |
| Gene symbol | Recql5 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity). |
| Sequence | MSARPFSTPF DRERRVRSTL KKVFGFDSFK TPLQESAIMA VVKGDKDVFV CMPTGAGKSL 60 CYQLPAVLAK GITIVVSPLI ALIQDQVDHL LALKVQVSSL NSKLSVQERK ELLSDLERDK 120 PRTKLLYITP EMAASASFQP TLNSLLSRNL LSYLVVDEAH CVSQWGHDFR PDYLRLGALR 180 SRLAHAPCVA LTATATPQVQ EDVFAALHLK QPVASFKTPC FRANLFYDVQ FKELIPDVYG 240 NLRDFCLKAL GQKADNGSSS GCGIVYCRTR EACEQLAIEL SSRGVNAKAY HAGLKASERT 300 QVQNEWMEEK VPVIVATISF GMGVDKANVR FVAHWNIAKS MAGYYQESGR AGRDGKPSWC 360 RLYYSRNDRD QVSFLIRKEL AKLQEKRGNK PSDKATLLAF DALVTFCEEV GCRHAAIAKY 420 FGDAPPACAK GCDCCQSPAA IRKKLDALEH SSSWGKTCIG PSQGDGFDPE LYEGGRRGYG 480 GFSRYDEGSG GSGDEGRDEA HKREWNLFYQ RQMSLRKGKE AKPEEFTPPG EDCPLRDASS 540 RKIPKLTVKA REHCLRLLEE ALNSNHQAAG STHGADLQAK AVELEHETFR SAKMVNLYKA 600 SVLKKVAEIH KASKDGQLYD MESSTKSCGA IAELLEPSDY DIPPTSHLYS LKPKRVGAGF 660 SKGPCPFQTA TELLGKSQTE KLAPEAALES EQEPSGWVCD PQDGDRSKPC LGYQEEAPGS 720 RTNCGDPSPE KRTKGSSQGS AKARASKRQQ LLATAARKDS QSITRFLRQR TECPPPAASV 780 PSSEDASPCG DVPGKCTEEV GAQGHLVAVF QTECPRERLS TCSLEDQSLP KGQPSPLKET 840 QAEKRPRPQQ ESQEKRAQKR LRPSTNSSAL ASDPSTENRV AREPCQLSAP GISLKEAADI 900 VVRYLTPFYK EGRFISKDLF KGFARHLSHL LAQKLSPGRS VKEEAQSLIK QFFHNRARCE 960 SEADWHGLCG PQR 973 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RECQL5 | 512590 | E1BKM5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RECQL5 | 483317 | F1PAG8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RECQL5 | 102169794 | A0A452E119 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RECQL5 | 9400 | O94762 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Recql5 | 170472 | Q8VID5 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | RECQL5 | G1TZG6 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Recql5 | 287834 | D4ACP5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | recql5 | 566553 | X1WCM8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005694 | chromosome |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0005634 | nucleus |
| GO:0016591 | RNA polymerase II, holoenzyme |
| GO:0043138 | 3'-5' DNA helicase activity |
| GO:0005524 | ATP binding |
| GO:0003678 | DNA helicase activity |
| GO:0009378 | four-way junction helicase activity |
| GO:0042802 | identical protein binding |
| GO:0003676 | nucleic acid binding |
| GO:0000993 | RNA polymerase II complex binding |
| GO:0051301 | cell division |
| GO:0072757 | cellular response to camptothecin |
| GO:0035690 | cellular response to drug |
| GO:0051304 | chromosome separation |
| GO:0032508 | DNA duplex unwinding |
| GO:0006310 | DNA recombination |
| GO:0006281 | DNA repair |
| GO:0006260 | DNA replication |
| GO:0006268 | DNA unwinding involved in DNA replication |
| GO:0000724 | double-strand break repair via homologous recombination |
| GO:0000278 | mitotic cell cycle |
| GO:2000042 | negative regulation of double-strand break repair via homologous recombination |
| GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter |
| GO:1990414 | replication-born double-strand break repair via sister chromatid exchange |