| Tag | Content |
|---|---|
| Uniprot ID | E1BCF7 |
| Entrez ID | 528490 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001192662.1 |
| Ensembl protein ID | ENSBTAP00000044029 |
| Ensembl nucleotide ID | ENSBTAG00000005741 |
| Gene name | Distal-less homeobox 2 |
| Gene symbol | DLX2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGGGAGPGGS NGSSLHKPQE SPTLPVSTAT 60 DSSYYTNQQH PAGGGGGGGG GSPYAHMGSY QYHASGLNNV PFSAKSGYDL GYTAAYTSYA 120 PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK KVRKPRTIYS SFQLAALQRR FQKTQYLALP 180 ERAELAASLG LTQTQVKIWF QNRRSKFKKM WKSGEIPSEQ HPGTSASPPC ASPPASAPAS 240 WDFGAPQRMG GGGGGPGSGG SGAGSSGSSP SSAASAFLGN YPWYHQASGS ASHLQAAAPL 300 LHPTQTPQPH HHHHHHHGGG GGAPVSAGTI F 331 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DLX2 | 528490 | E1BCF7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 100856541 | E2R5E5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 102188447 | A0A452FZW1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 1746 | Q07687 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dlx2 | 13392 | P40764 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | DLX2 | 459741 | K7AA60 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 100523029 | F1S082 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Dlx2 | 296499 | G3V668 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dlx2a | 30574 | F6NKE2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0003727 | single-stranded RNA binding |
| GO:0048755 | branching morphogenesis of a nerve |
| GO:0051216 | cartilage development |
| GO:0030154 | cell differentiation |
| GO:0021893 | cerebral cortex GABAergic interneuron fate commitment |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0021766 | hippocampus development |
| GO:0045746 | negative regulation of Notch signaling pathway |
| GO:0048715 | negative regulation of oligodendrocyte differentiation |
| GO:0046533 | negative regulation of photoreceptor cell differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0021772 | olfactory bulb development |
| GO:1902871 | positive regulation of amacrine cell differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0009954 | proximal/distal pattern formation |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0021882 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment |
| GO:0021544 | subpallium development |